CAS 470-37-1

Cinobufagina

Descrizione:

Cinobufagina è un composto che si verifica naturalmente classificato come un bufadienolide, che è un tipo di glicoside steroideo. È derivato principalmente dalla pelle di alcuni rospi, in particolare quelli del genere Bufo. Questo composto mostra una gamma di attività biologiche, inclusi effetti cardiotonici, che possono influenzare le contrazioni del muscolo cardiaco. Cinobufagina è stato studiato per le sue potenziali applicazioni terapeutiche, in particolare nella medicina tradizionale, dove si ritiene che possieda proprietà antitumorali, anti-infiammatorie e immunomodulatrici. La sostanza è caratterizzata dalla sua complessa struttura molecolare, che include uno scheletro steroideo e specifici gruppi funzionali che contribuiscono alla sua attività biologica. Tuttavia, a causa dei suoi effetti potenti, Cinobufagina può anche mostrare tossicità, richiedendo una considerazione attenta nel suo utilizzo. La ricerca continua a esplorare i suoi meccanismi d'azione e le potenziali applicazioni cliniche, affrontando anche le preoccupazioni relative alla sicurezza e all'efficacia. Come molti composti naturali, il profilo farmacologico di Cinobufagina è di grande interesse sia nei contesti medicinali tradizionali che moderni.

Formula: C₂₆H₃₄O₆

InChI: InChI=1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1

InChI key: InChIKey=SCULJPGYOQQXTK-OLRINKBESA-N

SMILES: C[C@]12[C@]3([C@](O3)([C@H](OC(C)=O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H]

Sinonimi:

• (3Beta,5Beta,15Beta,16Beta)-16-(Acetyloxy)-3-Hydroxy-14,15-Epoxybufa-20,22-Dienolide
• (3beta,5beta,8xi,9xi,10xi,13xi,14beta,15beta,16beta,17beta)-3-hydroxy-17-(2-oxo-2H-pyran-4-yl)-14,15-epoxyandrostan-16-yl acetate
• (3β,5β,15β,16β)-16-(Acetyloxy)-14,15-epoxy-3-hydroxybufa-20,22-dienolide
• 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
• 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,16β-dihydroxy-, 16-acetate
• Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)-
• Cinobufagenin
• Cinobufagin
• Cinobufagine
• Cinobufogenin
• NSC 90325

Cinobufagine

CAS: 470-37-1

Formula: C₂₆H₃₄O₆

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 442.55

Ref: 3B-C3460

Cinobufagin

CAS: 470-37-1

Formula: C₂₆H₃₄O₆

Purezza: ≥ 98.0%

Colore e forma: White or off-white powder

Peso molecolare: 442.54

Ref: 7W-GP7595

Cinobufagin

CAS: 470-37-1

Cinobufagin

Purezza: ≥95%

Peso molecolare: 442.54g/mol

Ref: 54-BUP07390

Cinobufagin

CAS: 470-37-1

Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer, it also has anti-hepatitis B virus activity . Cinobufagin inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway. Cinobufagin can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue.Cinobufagin and bufalin exhibit cardiotonic and natriuretic activities, they also have inhibitory effects on steroidogenesis of aldosterone and cortisol.

Formula: C₂₆H₃₄O₆

Purezza: 95%~99%

Peso molecolare: 442.552

Ref: BP-BP0366

Cinobufagin

CAS: 470-37-1

Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.

Formula: C₂₆H₃₄O₆

Purezza: 97.77% - 99.97%

Colore e forma: Solid

Peso molecolare: 442.54

Ref: TM-T3432

Cinobufagin

CAS: 470-37-1

Lactone

Formula: C₂₆H₃₄O₆

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 442.55

Ref: 5G-89609

Cinobufagine-d3

Prodotto controllato

CAS: 470-37-1

Applications Isotope labelled Cinobufagine (C475500) is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Formula: C₂₆H₃₁D₃O₆

Colore e forma: White To Off-White

Peso molecolare: 445.56

Ref: TR-C475502

Cinobufagin - Bio-X ™

CAS: 470-37-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₆H₃₄O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 442.54 g/mol

Ref: 3D-BC300057

Cinobufagin

CAS: 470-37-1

Cinobufagin is a bufadienolide compound, which is a type of steroid. It is sourced from the venom of the Chinese toad, Bufo bufo gargarizans, commonly used in traditional Chinese medicine. The compound exerts its effects primarily through the modulation of cellular signaling pathways, such as inhibiting the Na+/K+-ATPase pump, which leads to alterations in ion gradients and subsequent induction of apoptosis in cancer cells.

Formula: C₂₆H₃₄O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 442.54 g/mol

Ref: 3D-FC65673

Cinobufagine

Prodotto controllato

CAS: 470-37-1

Applications Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Formula: C₂₆H₃₄O₆

Colore e forma: Neat

Peso molecolare: 442.54

Ref: TR-C475500