CAS 472-15-1

Acido betulinico

Descrizione:

Acido betulinico è un composto triterpenoide pentaciclico che si trova naturalmente, derivato principalmente dalla corteccia dell'albero di betulla (specie di Betula). È caratterizzato dalla sua apparente cristallina bianca e ha una formula molecolare di C30H48O3. Acido betulinico è noto per le sue diverse attività biologiche, comprese le proprietà antinfiammatorie, antivirali e anticancro. È stato studiato per i suoi potenziali effetti terapeutici contro vari tipi di cancro, poiché può indurre apoptosi nelle cellule tumorali risparmiando le cellule normali. Inoltre, Acido betulinico presenta proprietà antimicrobiche e ha mostrato promesse nel trattamento di condizioni come l'HIV e altre infezioni virali. Il suo meccanismo d'azione spesso implica la modulazione delle vie di segnalazione cellulare e l'induzione di stress ossidativo nelle cellule cancerose. A causa della sua origine naturale e bioattività, Acido betulinico è di grande interesse nella ricerca e sviluppo farmaceutico, sebbene siano necessari ulteriori studi per comprendere appieno la sua efficacia e sicurezza nelle applicazioni cliniche.

Formula: C₃₀H₄₈O₃

InChI: InChI=1/C29H46O3/c1-17(2)18-9-15-29(25(31)32)16-10-20-19(24(18)29)7-8-22-27(20,5)13-11-21-26(3,4)23(30)12-14-28(21,22)6/h18-24,30H,1,7-16H2,2-6H3,(H,31,32)/t18-,19-,20?,21?,22?,23+,24?,27-,28-,29-/m0/s1

InChI key: InChIKey=QGJZLNKBHJESQX-FZFNOLFKSA-N

SMILES: C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

Sinonimi:

• (1R,3aS,5bS,9R,11aR,13aS)-9-hydroxy-5b,8,8,11a-tetramethyl-1-(1-methylethenyl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid
• (3Beta)-3-Hydroxylup-20(29)-En-28-Oic Acid
• (3Beta,5Xi,9Xi,13Xi,18Xi)-3-Hydroxylup-20(29)-En-28-Oic Acid
• (3β)-3-Hydroxylup-20(29)-en-28-oic acid
• 3-Hydroxylup-20(29)-en-28-oic acid
• 3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv.
• 3β-Hydroxylup-20(29)-en-28-oic acid
• Acide Lupene-20(29) Oique-28, Hydroxy-3, (3Β)-
• Acido Lup-20(29)-En-28-Oico, 3-Hidroxi-, (3Β)-
• Betulic acid
• Ccris 6748
• Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-
• Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3β)-
• Lup-20(29)-en-28-oic acid, 3beta-hydroxy-
• Lup-20(29)-en-28-oic acid, 3β-hydroxy-
• Lup-20(29)-en-28-olsaure, 3-Hydroxy-, (3β)-
• Lupatic acid
• Mairin
• Nsc 113090
• Nsc 677578
• β-Betulinic acid
• Platanol
• BETULICACID: LUP-20(29)-EN-28-OICACID, 3-HYDROXY-, (3B)-,
• Betulinic
• (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentaMethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid
• BETULINIC ACID
• AIRIN
• 3-B-HYDROXY-LUPA-20(30)-ENE 28-OIC ACID
• 3BETA-HYDROXY-20(29)-LUPENE-28-OIC ACID
• Einecs 207-448-8
• Melaleucin
• Gratiolone
• 3BETA-HYDROXY-20(29)-LUPAENE-28-OIC ACID
• ALS-357
• BETULINIC ACID WITH HPLC
• 3β-hydroxy-20(29)-lupaene-28-oic acid
• BETULINIC ACID hplc
• 3B-HYDROXY-20(29)-LUPENE-28-OIC ACID
• Betulinic acid technical grade, 90%
• (+)-(3β)-3-Hydroxylup-20(29)-en-28-oicacid
• Lup-20(29)-en-28-oic acid, 3beta-hydroxy-(8ci)
• 3β-hydroxy-lup-20(29)-ene-28-oicacid
• Betulinic Acid(98%)
• Platanolic acid
• BETULINIC ACID, TECH., 90%

Betulinic acid

CAS: 472-15-1

Betulinic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₃₀H₄₈O₃

Purezza: (HPLC) ≥98%

Colore e forma: Powder

Peso molecolare: 456.71

Ref: 11-0031S

Betulinic acid

CAS: 472-15-1

Formula: C₃₀H₄₈O₃

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 456.7003

Ref: IN-DA003O6L

Betulinic acid

CAS: 472-15-1

Formula: C₃₀H₄₈O₃

Purezza: ≥ 97.0%

Colore e forma: White to off-white or light-yellow powder

Peso molecolare: 456.70

Ref: 7W-GP1450

Betulinic acid

CAS: 472-15-1

Betulinic acid

Purezza: ≥98%

Peso molecolare: 456.7g/mol

Ref: 54-BUP16011

Betulinic acid

CAS: 472-15-1

Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli.

Formula: C₃₀H₄₈O₃

Purezza: 95%~99%

Peso molecolare: 456.711

Ref: BP-BP0271

Betulinic acid

CAS: 472-15-1

Betulinic acid

Formula: C₃₀H₄₈O₃

Purezza: 98%

Colore e forma: white powder

Peso molecolare: 456.70g/mol

Ref: 54-BIDF1001

Betulinic acid

CAS: 472-15-1

Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.

Formula: C₃₀H₄₈O₃

Purezza: 98.22% - 99.7%

Colore e forma: White Crystalline Powder

Peso molecolare: 456.70

Ref: TM-T2830

Betulinic acid with hplc

CAS: 472-15-1

Betulinic acid with hplc

Purezza: 98%

Peso molecolare: 456.70g/mol

Ref: 54-BIDF1011

Betulinic acid

CAS: 472-15-1

Carboxylic acid with alcohol function

Formula: C₃₀H₄₈O₃

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 456.71

Ref: 5G-89529

Betulinic Acid

CAS: 472-15-1

Applications Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);

Formula: C₃₀H₄₈O₃

Colore e forma: Neat

Peso molecolare: 456.7

Ref: TR-B330250

Betulinic acid

CAS: 472-15-1

Betulinic acid is a pentacyclic triterpenoid, which is derived from the bark of birch trees among other plants. This compound exerts its effects primarily through the induction of apoptosis in cancer cells, interference with viral replication, and modulation of inflammatory pathways. Its mode of action includes mitochondrial membrane potential disruption, inhibition of topoisomerase, and interaction with the NF-kB signaling pathway.

Formula: C₃₀H₄₈O₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 456.7 g/mol

Ref: 3D-FB16425

3-epi-Betulinic Acid-d3

Prodotto controllato

CAS: 472-15-1

Applications 3-epi-Betulinic Acid-d3 is an isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. In addition, 3-epi-Betulinic Acid-d3 is an epimer by-product isomer of Betulinic Acid-d3 (B330252).
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

Formula: C₃₀D₃H₄₅O₃

Colore e forma: Neat

Peso molecolare: 459.719

Ref: TR-B330251

Betulinic Acid

CAS: 472-15-1

Formula: C₃₀H₄₈O₃

Purezza: >97.0%(GC)(T)

Colore e forma: White to Light yellow to Light orange powder to crystal

Peso molecolare: 456.71

Ref: 3B-B2836

Betulinic acid

CAS: 472-15-1

M01408 - Betulinic acid

Formula: C₃₀H₄₈O₃

Purezza: 97%

Colore e forma: Solid, Crystalline Powder or Powder

Peso molecolare: 456.711

Ref: 10-M01408

Betulinic Acid-d3

Prodotto controllato

CAS: 472-15-1

Applications Betulinic Acid-d3 is the isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity.
References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)

Formula: C₃₀H₄₅D₃O₃

Colore e forma: Neat

Peso molecolare: 459.72

Ref: TR-B330252