CAS 475207-59-1

Nexavar

Descrizione:

Nexavar, con il numero CAS 475207-59-1, è il nome commerciale del sorafenib, un inibitore della tirosina chinasi a piccole molecole utilizzato principalmente nel trattamento del cancro. È caratterizzato dalla sua capacità di inibire più chinasi coinvolte nella proliferazione delle cellule tumorali e nell'angiogenesi, comprese le chinasi Raf e le chinasi del recettore della tirosina come VEGFR e PDGFR. Il sorafenib è tipicamente somministrato per via orale ed è noto per il suo ruolo nel trattamento del carcinoma renale avanzato e del carcinoma epatocellulare. Il composto è un solido di colore giallo pallido a bianco sporco, con una formula molecolare che include carbonio, idrogeno, azoto, ossigeno e fluoro. Il suo meccanismo d'azione implica l'interruzione delle vie di segnalazione che promuovono la crescita delle cellule cancerose e la formazione di vasi sanguigni, rallentando così la progressione del tumore. Nexavar è spesso associato a effetti collaterali come affaticamento, diarrea e reazioni cutanee, che sono considerazioni importanti nella gestione del paziente. In generale, il sorafenib rappresenta un significativo progresso nelle terapie mirate contro il cancro, offrendo un approccio strategico per combattere specifiche malignità.

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈SO₃

InChI: InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

InChI key: InChIKey=IVDHYUQIDRJSTI-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(NC)=O)N=CC1)C2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2.S(=O)(=O)(O)C1=CC=C(C)C=C1

Sinonimi:

• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1)
• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, mono(4-methylbenzenesulfonate)
• 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate
• BAY 43-9006 mono-p-tosylate
• Bay 54-9085
• N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Tolsylate
• Nexavar
• Sorafenib TsOH salt
• Sorafenib p-toluenesulfonate
• Sorafenib-D3
• Sorafenib tosylate

Sorafenib Tosylate

CAS: 475207-59-1

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 637.03

Ref: 3B-N1229

Sorafenib Tosylate

CAS: 475207-59-1

Colore e forma: Neat

Ref: 61-FOR3585.00

SORAFENIB FOR PEAK IDENTIFICATION CRS

CAS: 475207-59-1

SORAFENIB FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002236

SORAFENIB TOSILATE CRS

CAS: 475207-59-1

SORAFENIB TOSILATE CRS

Ref: 41-Y0002224

SORAFENIB CRS

CAS: 475207-59-1

SORAFENIB CRS

Ref: 41-Y0002098

SORAFENIB FOR PEAK IDENTIFICATION A CRS

CAS: 475207-59-1

SORAFENIB FOR PEAK IDENTIFICATION A CRS

Ref: 41-Y0002488

Sorafenib Tosylate

CAS: 475207-59-1

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Colore e forma: White Brown Powder

Peso molecolare: 636.10572

Ref: 45-1615876

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-methylbenzene-1-sulfonic acid

CAS: 475207-59-1

Formula: C₂₈H₂₄ClF₃N₄O₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 637.0266

Ref: IN-DA0035M4

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Purezza: 99.24% - 99.94%

Colore e forma: White To Off-White Crystalline Powder

Peso molecolare: 637.03

Ref: TM-T0093

Sorafenib tosylate

CAS: 475207-59-1

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White, off-white or pale yellow-brown powder

Peso molecolare: 637.03

Ref: 7W-GK5261

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib tosylate

Purezza: ≥98%

Peso molecolare: 637.03g/mol

Ref: 54-BUP17105

Sorafenib Tosylate

CAS: 475207-59-1

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Colore e forma: Off-White Solid

Peso molecolare: 464.83 172.20

Ref: 4Z-S-2738

Sorafenib Tosylate

Prodotto controllato

CAS: 475207-59-1

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Colore e forma: Neat

Peso molecolare: 637.03

Ref: 86-MM3585.00

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib tosylate

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Purezza: 99%+

Colore e forma: off-white solid

Peso molecolare: 637.03g/mol

Ref: 54-BISN0216

Sorafenib Tosylate

Prodotto controllato

CAS: 475207-59-1

Formula: C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

Colore e forma: Neat

Peso molecolare: 637.03

Ref: TR-S676845

Sorafenib Tosylate

CAS: 475207-59-1

Formula: C₂₁H₁₆ClF₃N₄O₃C₇H₈O₃S

Peso molecolare: 464.83 : 172.2

Ref: ST-EA-CP-S16021

Sorafenib tosylate

CAS: 475207-59-1

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib tosylate has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes.

Formula: C₂₁H₁₆ClF₃N₄O₃•C₇H₈O₃S

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 637.03 g/mol

Ref: 3D-FS10808

Sorafenib tosylate - Bio-X ™

CAS: 475207-59-1

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib tosylate has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib tosylate also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes.
Sorafenib tosylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₁H₁₆ClF₃N₄O₃•C₇H₈O₃S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 637.03 g/mol

Ref: 3D-BS164414

Sorafenib, p-Toluenesulfonate Salt

CAS: 475207-59-1

Formula: C₃₅H₃₀F₃N₇O₄S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 701.73

Ref: 10-F050782