CAS 477-30-5

Demecolcina

Descrizione:

Demecolcina è un composto chimico classificato come un derivato della colchicina, noto principalmente per il suo utilizzo nella ricerca biologica e come potenziale agente terapeutico. È caratterizzato dalla sua capacità di inibire la polimerizzazione dei microtubuli, il che interrompe la formazione del fuso mitotico, rendendolo prezioso negli studi sulla divisione cellulare e nella ricerca sul cancro. Demecolcina è tipicamente presentato come una polvere cristallina bianca o bianco sporco ed è solubile in solventi organici come il dimetilsolfossido (DMSO) e leggermente solubile in acqua. Il composto ha una formula molecolare che riflette la sua struttura complessa, che include un anello fenolico e un gruppo metossile. A causa della sua attività biologica, Demecolcina è stato studiato per le sue potenziali applicazioni nel trattamento di alcuni tipi di cancro e disturbi genetici, sebbene il suo utilizzo sia spesso limitato dalla tossicità e dagli effetti collaterali. Come per molte sostanze chimiche, una corretta manipolazione e precauzioni di sicurezza sono essenziali quando si lavora con Demecolcina in ambienti di laboratorio.

Formula: C₂₁H₂₅NO₅

InChI: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

InChI key: InChIKey=NNJPGOLRFBJNIW-HNNXBMFYSA-N

SMILES: O(C)C1=C2C=3C([C@@H](NC)CCC2=CC(OC)=C1OC)=CC(=O)C(OC)=CC3

Sinonimi:

• (-)-Colchamine
• (7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
• (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one
• (N-Desacetyl-N-methylcolchicine)
• 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
• Alkaloid H 3, from Colchicum antumnale
• Alkaloid H 3, from Colchicumantumnale
• Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
• Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-
• C 12669
• Ciba 12669A
• Colcemid
• Colcemide
• Colchamin
• Colchicine, N-deacetyl-N-methyl-
• Deacetyl-N-methylcolchicine
• Deacetylmethylcolchicine
• Demecolcin
• Demecolcina
• Demecolcine
• Demecolcine, (S)-(-)-
• Desacetylmethylcolchicine
• Desmecolcine
• Kolchamin
• N-Deacetyl-N-methylcolchicine
• N-Methyl-N-deacetylcolchicine
• N-Methyl-N-desacetylcolchicine
• N-Methyltri-O-methylcolchicinic acid
• Nsc 3096
• Omain
• Omaine
• Reichstein's F
• Santavy's substance F

Demecolcine

CAS: 477-30-5

Formula: C₂₁H₂₅NO₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 371.4269

Ref: IN-DA00DDYO

Colcemid

CAS: 477-30-5

Colcemid

Purezza: ≥98%

Peso molecolare: 371.43g/mol

Ref: 54-BUP02609

(-)-Demecolcine

CAS: 477-30-5

(-)-Demecolcine

Purezza: 97%

Peso molecolare: 371.43g/mol

Ref: 54-OR1023885

Demecolcine

CAS: 477-30-5

Formula: C₂₁H₂₅NO₅

Purezza: ≥ 98.0%

Colore e forma: White, off-white or pale yellow crystalline powder

Peso molecolare: 371.43

Ref: 7W-GP5459

Demecolcine-13C,d3

CAS: 477-30-5

Formula: C₂₀₁₃CH₂₂D₃NO₅

Peso molecolare: 375.44

Ref: 4Z-C-1530

Demecolcine

CAS: 477-30-5

Formula: C₂₁H₂₅NO₅

Peso molecolare: 371.43

Ref: 4Z-C-1533

Demecolcine

CAS: 477-30-5

Stability Hygroscopic
Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

Formula: C₂₁H₂₅NO₅

Colore e forma: Neat

Peso molecolare: 371.43

Ref: TR-D230785

Colcemid

CAS: 477-30-5

Colcemid (NSC-3096) is a microtubule polymerization inhibitor,main target being Tubulin and an IC50 of 2.4 μM. induce apoptosis. High-Quality, Low-Cost!

Formula: C₂₁H₂₅NO₅

Purezza: 99.65% - 99.83%

Colore e forma: Solid

Peso molecolare: 371.43

Ref: TM-T19720

Demecolcine

CAS: 477-30-5

Demecolcine is a substance that is found in plants. It has been shown to have cytotoxic effects on human cells and to inhibit the growth of hl-60 cells by interfering with microtubule formation. Demecolcine binds to the microtubules, preventing them from polymerizing and causing mitotic arrest in cell cycle. Demecolcine also blocks the production of tubulin, which are proteins that are needed for microtubule formation. This drug has been shown to be effective against colchicine-resistant cells that are resistant to other cytotoxic agents as well. The rate constant for demecolcine's binding to microtubules is 0.2 s-1, which is higher than that of colchicine (0.05 s-1). The signal peptide sequence of demecolcine has been found in human chromosome 1q42 and chromosome 4q21, suggesting it may play a role in the

Formula: C₂₁H₂₅NO₅

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 371.43 g/mol

Ref: 3D-FC15451

Demecolcine

CAS: 477-30-5

Please enquire for more information about Demecolcine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₁H₂₅NO₅

Purezza: Min. 98 Area-%

Peso molecolare: 371.43 g/mol

Ref: 3D-J-100064