CAS 486-35-1

Dafnetina

Descrizione:

Dafnetina, con il numero CAS 486-35-1, è un derivato della cumarina che si trova naturalmente, estratto principalmente dalla corteccia del genere Daphne, in particolare da Daphne mezereum. È caratterizzato dalla sua apparente cristallina bianca e ha una formula molecolare di C10H8O4. Dafnetina mostra una gamma di attività biologiche, comprese proprietà anti-infiammatorie, antiossidanti e antimicrobiche, rendendolo di interesse nella ricerca farmacologica. Il composto è solubile in solventi organici come etanolo e dimetilsolfossido, ma ha una solubilità limitata in acqua. La struttura di Dafnetina presenta un gruppo idrossile e un gruppo metossile, contribuendo alla sua reattività e potenziali interazioni con vari bersagli biologici. Inoltre, è stato studiato per le sue potenziali applicazioni terapeutiche, incluso il suo ruolo nella modulazione delle vie di segnalazione relative all'infiammazione e al cancro. Come molti composti naturali, è necessaria ulteriore ricerca per chiarire completamente i suoi meccanismi d'azione e i potenziali usi clinici.

Formula: C₉H₆O₄

InChI: InChI=1/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

InChI key: InChIKey=ATEFPOUAMCWAQS-UHFFFAOYSA-N

SMILES: OC1=C2C(=CC=C1O)C=CC(=O)O2

Sinonimi:

• 2H-1-Benzopyran-2-one, 7,8-dihydroxy-
• 2H-1-benzopyran-2-one, 4,8-dihydroxy-
• 4,8-Dihydroxy-2H-chromen-2-one
• 7,8-Dihydroxy-2H-1-benzopyran-2-one
• 7,8-Dihydroxycoumarin
• 7,8-dihydroxy-2H-benzopyran-2-one
• 7,8-dihydroxy-2H-chromen-2-one
• Coumarin, 7,8-dihydroxy-
• Daphnetol
• NSC 633563
• Ruixiangsu
• Daphnetin
• Daphenetin
• Daphnetin，7,8-Dihydroxycoumarin
• DAPHNETIN(P)
• AKOS 213-37
• 7,8-dihydroxy-coumari
• 7,8-DIHYDROXY-CHROMEN-2-ONE
• 7,8-dihydroxy-2h-1-benzopyran-2-on
• 7,8-DIHYDROXYCOUMARIN (DAPHNETIN)

Daphnetin

CAS: 486-35-1

Daphnetin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₉H₆O₄

Purezza: (HPLC) ≥95%

Colore e forma: Powder

Peso molecolare: 178.15

Ref: 11-0508

2H-1-Benzopyran-2-one, 7,8-dihydroxy-

CAS: 486-35-1

Formula: C₉H₆O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 178.1415

Ref: IN-DA00IKJP

7,8-Dihydroxycoumarin (Daphnetin)

CAS: 486-35-1

Formula: C₉H₆O₄

Purezza: (HPLC) ≥ 90.0%

Colore e forma: Off-white to light yellow or pink powder

Peso molecolare: 178.14

Ref: 7W-GE1263

7,8-Dihydroxycoumarin

CAS: 486-35-1

7,8-Dihydroxycoumarin

Purezza: 98%

Peso molecolare: 178.14g/mol

Ref: 54-OR345097

Daphnetin

CAS: 486-35-1

Daphnetin

Purezza: ≥95%

Peso molecolare: 178.14g/mol

Ref: 54-BUP13671

Daphnetin

CAS: 486-35-1

Formula: C₉H₆O₄

Purezza: 95%~99%

Peso molecolare: 178.143

Ref: BP-BP0449

Daphnetin

CAS: 486-35-1

Formula: C₉H₆O₄

Purezza: >90.0%(HPLC)

Colore e forma: White to Light yellow to Light red powder to crystal

Peso molecolare: 178.14

Ref: 3B-D4001

Daphnetin

CAS: 486-35-1

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),

Formula: C₉H₆O₄

Purezza: 97.47% - 99.8%

Colore e forma: Solid

Peso molecolare: 178.14

Ref: TM-T2851

7,8-Dihydroxycoumarin (Daphnetin)

CAS: 486-35-1

Formula: C₉H₆O₄

Peso molecolare: 178.14

Ref: 4Z-C-1637

Daphnetin

CAS: 486-35-1

Lactone

Formula: C₉H₆O₄

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 178.14

Ref: 5G-89621

7,8-Dihydroxycoumarin

CAS: 486-35-1

7,8-Dihydroxycoumarin is a naturally occurring coumarin, which is derived from plants and certain fungi. It possesses a distinct chemical structure characterized by a benzopyrone core with hydroxyl groups at the 7th and 8th positions, contributing to its distinct biochemical properties. The mode of action of 7,8-Dihydroxycoumarin is largely attributed to its ability to act as a potent antioxidant, scavenging free radicals and chelating metal ions, thus mitigating oxidative stress at the cellular level.

Formula: C₉H₆O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 178.14 g/mol

Ref: 3D-FD67369

7,8-Dihydroxycoumarin, tech grade - 40%

CAS: 486-35-1

7,8-Dihydroxycoumarin (7,8-DHC) is a natural compound that has been shown to inhibit the expression of the P-glycoprotein (Pgp) gene and protein. 7,8-DHC binds to the response element in the Pgp gene promoter and inhibits transcriptional activity. This inhibition of transcription prevents the production of new Pgp proteins, which leads to an increase in drug resistance. 7,8-DHC also has been shown to bind to bcl-2 protein in vitro and prevent its release from mitochondria. This prevents apoptosis by inhibiting mitochondrial membrane permeability. Coumarin derivatives have been shown as potential therapeutic agents for bowel diseases such as ulcerative colitis and Crohn's disease. Daphnetin, a coumarin derivative found in dandelion roots, has shown promise as a treatment for colitis in mice models.

Formula: C₉H₆O₄

Purezza: (%) Min. 40%

Colore e forma: Powder

Peso molecolare: 178.14 g/mol

Ref: 3D-FD146393

DAPHNETIN

CAS: 486-35-1

Formula: C₉H₆O₄

Purezza: 97%

Peso molecolare: 178.143

Ref: 10-F468316