CAS 489-32-7

Icarina

Descrizione:

Icarina è un glicoside flavonoide derivato principalmente dal genere Epimedium, comunemente noto come Erba di Capra Eccitata. È riconosciuto per le sue potenziali proprietà farmacologiche, inclusi effetti antiossidanti, antinfiammatori e neuroprotettivi. Icarina presenta una struttura complessa caratterizzata da uno scheletro di flavona con un moiety glicosidico, che contribuisce alla sua attività biologica. La sostanza è spesso studiata per i suoi potenziali benefici nel migliorare la salute sessuale e aumentare la densità ossea, rendendola di interesse nella medicina tradizionale e nella ricerca terapeutica moderna. Icarina si trova tipicamente in varie forme, tra cui polveri ed estratti, ed è spesso utilizzato in integratori alimentari. La sua solubilità in solventi organici e la solubilità limitata in acqua possono influenzare la sua biodisponibilità e efficacia. Come molti composti naturali, gli effetti specifici e i meccanismi d'azione di Icarina sono ancora sotto indagine, e il suo profilo di sicurezza è una considerazione importante per il suo utilizzo nei prodotti per la salute.

Formula: C₃₃H₄₀O₁₅

InChI: InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

InChI key: InChIKey=TZJALUIVHRYQQB-XLRXWWTNSA-N

SMILES: C(C=C(C)C)C1=C2C(C(=O)C(O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)=C(O2)C4=CC=C(OC)C=C4)=C(O)C=C1O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O

Sinonimi:

• 2,6-anhydro-1-deoxy-7-O-[7-(beta-D-glucopyranosyloxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl]-L-glycero-L-manno-heptitol
• 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
• 3-[(6-Deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)oxy]-7-(β-<smallcap>D</span>-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
• 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
• 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)oxy]-7-(β-<smallcap>D</span>-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
• 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)oxy]-7-(β-<smallcap>D</span>-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
• Epimedium
• Epimedium PE
• Epimedium extract
• Horny goat weed extract
• Icariine
• Icariln
• Ieariline
• Epimediun P.E.
• 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
• 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
• 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-

Icariin

CAS: 489-32-7

Formula: C₃₃H₄₀O₁₅

Purezza: >96.0%(HPLC)

Colore e forma: Light orange to Yellow to Green powder to crystal

Peso molecolare: 676.67

Ref: 3B-I0862

Icariin, 98%

CAS: 489-32-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₃₃H₄₀O₁₅

Purezza: 98%

Colore e forma: Pale yellow, Powder

Peso molecolare: 676.67

Ref: 02-J66324

Icariin

CAS: 489-32-7

Icariin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₃₃H₄₀O₁₅

Purezza: (HPLC) ≥99%

Colore e forma: Powder

Peso molecolare: 676.67

Ref: 11-1365S

ICARIIN CRS

CAS: 489-32-7

ICARIIN CRS

Ref: 41-Y0002517

Icariin

CAS: 489-32-7

Formula: C₃₃H₄₀O₁₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 676.6617

Ref: IN-DA00DLA6

Icariin

CAS: 489-32-7

Icariin

Purezza: ≥95%

Peso molecolare: 676.66g/mol

Ref: 54-BUP17052

Icariin

CAS: 489-32-7

Icariin

Purezza: 98%

Peso molecolare: 676.66g/mol

Ref: 54-OR1030336

Icariin

CAS: 489-32-7

Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Icariin has been reported to have anti-hypoxic, phytoestrogenic, anti-osteoporotic, anti-inflammatory, neuroprotective, and anti-depressant-like activities. Icariin is effective in the attenuation of AHR and chronic airway inflammatory changes in OVA-induced murine asthma model, and this effect is associated with regulation of Th17/Treg responses. Icariin inhibited NF-κB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1β axis.

Formula: C₃₃H₄₀O₁₅

Purezza: 95%~99%

Peso molecolare: 676.668

Ref: BP-BP0757

Icariin

CAS: 489-32-7

Icariin (Ieariline) is a flavonol glycoside that inhibits PDE5 and PDE4 activity and is a PPARα activator. Cost-effective and quality-assured.

Formula: C₃₃H₄₀O₁₅

Purezza: 97.82% - 98.3%

Colore e forma: Solid

Peso molecolare: 676.66

Ref: TM-T2855

Icariin-d6

CAS: 489-32-7

Formula: C₃₃H₃₄O₁₅D₆

Peso molecolare: 682.71

Ref: 4Z-I-080002

Icariin

CAS: 489-32-7

Formula: C₃₃H₄₀O₁₅

Purezza: ≥ 96.0%

Colore e forma: Pale yellow to yellow powder

Peso molecolare: 676.66

Ref: 7W-GC6166

Icariin

CAS: 489-32-7

Formula: C₃₃H₄₀O₁₅

Peso molecolare: 676.68

Ref: 4Z-I-080001

Icariin

CAS: 489-32-7

Natural glycoside

Formula: C₃₃H₄₀O₁₅

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 676.67

Ref: 5G-89714

Icariin

Prodotto controllato

CAS: 489-32-7

Stability Light Sensitive
Applications Icariin inhibits the ROS-dependent JNK and p38 pathways.
References Zhou, H., et al.: Exp. Ther. Med., 7, 1116 (2014)

Formula: C₃₃H₄₀O₁₅

Colore e forma: Neat

Peso molecolare: 676.66

Ref: TR-I163680

Icariin

CAS: 489-32-7

Icariin is a bioactive flavonoid compound, which is primarily derived from plants in the genus Epimedium, commonly known as Horny Goat Weed. This compound is a prenylated flavonol glycoside that is found in varying concentrations depending on the specific species of Epimedium used. Icariin exerts its effects through multiple biochemical pathways, most notably by inhibiting phosphodiesterase type 5 (PDE5), which leads to an increase in nitric oxide levels and the subsequent vasodilation of blood vessels.

Formula: C₃₃H₄₀O₁₅

Purezza: Min. 95%

Colore e forma: Slightly Yellow Powder

Peso molecolare: 676.66 g/mol

Ref: 3D-MI08119

ICARIIN

CAS: 489-32-7

Purezza: 98%

Peso molecolare: 676.6680298

Ref: 10-F859338