CAS 490-82-4

3-[(4-Amino-2-metil-5-pirimidinil)metil]-5-(2-idrossietil)-4-metil-2(3H)-tiazolone

Descrizione:

La sostanza chimica nota come 3-[(4-Amino-2-metil-5-pirimidinil)metil]-5-(2-idrossietil)-4-metil-2(3H)-tiazolone, con il numero CAS 490-82-4, è un derivato della tiazolona che presenta una struttura molecolare complessa. Presenta un anello di tiazolona, che è un composto eterociclico a cinque membri contenente zolfo e azoto, contribuendo alla sua attività biologica. La presenza di un gruppo pirimidina indica potenziali interazioni con sistemi biologici, in particolare in relazione al metabolismo degli acidi nucleici. Questo composto è caratterizzato dai suoi gruppi funzionali amminici e idrossietilici, che possono migliorare la solubilità e la reattività. Viene spesso studiato per le sue potenziali proprietà farmacologiche, comprese le attività antimicrobiche e antitumorali. La struttura unica del composto consente varie modifiche chimiche, che possono influenzare la sua efficacia e il profilo di sicurezza nelle applicazioni terapeutiche. Come per molti derivati della tiazolona, è essenziale considerare la sua stabilità, solubilità e reattività in diversi ambienti quando si valutano i suoi usi pratici in chimica medicinale.

Formula: C₁₂H₁₆N₄O₂S

InChI: InChI=1/C12H16N4O2S/c1-7-10(3-4-17)19-12(18)16(7)6-9-5-14-8(2)15-11(9)13/h5,17H,3-4,6H2,1-2H3,(H2,13,14,15)

InChI key: InChIKey=VXCONGLPCAPYEU-UHFFFAOYSA-N

SMILES: C(N1C(C)=C(CCO)SC1=O)C=2C(N)=NC(C)=NC2

Sinonimi:

• (3H)-Thiazolone, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-
• 2(3H)-Thiazolone, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-
• 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-(3H)-thiazolone
• 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolin-2-one
• 3-((4-Amino-2-metil-5-pirimidinil)metil)-5-(2-idrossietil)-4-metiltiazolin-2-one
• 3-((4-Amino-2-metil-5-pirimidinil)metil)-5-(2-idrossietil)-4-metiltiazolin-2-one [Italian]
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-2(3H)-thiazolone
• 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2(3H)-one
• 4-Thiazolin-2-one, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-
• Brn 0310984
• Thiamin thiazolone
• Thiamine thiazolone
• Thiaminthiazolone
• Tiamintiazolone
• Tiamintiazolone [Italian]
• 4-27-00-03500 (Beilstein Handbook Reference)
• 3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one
• 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazol-2-one
• 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2-one
• 3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-2-one
• Oxo ThiaMine
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one

3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-one

CAS: 490-82-4

Formula: C₁₂H₁₆N₄O₂S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 280.3460

Ref: IN-DA00DF4Z

Oxo thiamine

CAS: 490-82-4

Oxo thiamine

Purezza: 98%

Peso molecolare: 280.35g/mol

Ref: 54-OR1007293

Thiamine EP Impurity D (Oxo Thiamine)

CAS: 490-82-4

Formula: C₁₂H₁₆N₄O₂S

Colore e forma: White To Off-White Solid

Peso molecolare: 280.35

Ref: 4Z-T-845

Thiamine EP Impurity D

CAS: 490-82-4

Formula: C₁₂H₁₆N₄O₂S

Peso molecolare: 280.35

Ref: ST-EA-CP-T2004

Oxo Thiamine

CAS: 490-82-4

Applications Thiamine (T344185) impurity.
References Warnock, L., et al.: Anal. Biochem., 126, 394 (1982), Royer-Morrot, J., et al.: Eur. J. Clin. Pharmacol., 42, 219 (1992),

Formula: C₁₂H₁₆N₄O₂S

Colore e forma: Off-White

Peso molecolare: 280.35

Ref: TR-O864200

Oxo thiamine

CAS: 490-82-4

Oxo thiamine (OT) is a group II intramolecular hydrogen donor that has been shown to be effective against various types of cancer. OT is a competitive inhibitor of the bacterial enzyme sulfamidase, which is responsible for hydrolyzing sulfamethoxazole resulting in resistance to this antibiotic. In addition, OT inhibits mitochondrial complex I and causes a loss in mitochondrial membrane potential. OT also has anti-inflammatory properties and can be used as an analog in nuclear DNA synthesis. OT binds to the nitrogen atom on the phosphate group of ATP and forms a hydrogen bond with the oxygen atom on the same phosphate group, inhibiting enzymatic reactions.

Formula: C₁₂H₁₆N₄O₂S

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 280.35 g/mol

Ref: 3D-FO26662