CAS 50-35-1

Talidomide

Descrizione:

Talidomide, con il numero CAS 50-35-1, è un composto sintetico sviluppato originariamente alla fine degli anni '50 come sedativo e successivamente prescritto per la nausea mattutina nelle donne in gravidanza. È classificato come un derivato della ftalimide e ha una formula molecolare di C13H10N2O4. Talidomide è noto per il suo meccanismo d'azione unico, che include effetti immunomodulatori, proprietà anti-infiammatorie e inibizione dell'angiogenesi. La sua struttura presenta un centro chirale, portando a due enantiomeri, uno dei quali è associato agli effetti terapeutici del farmaco, mentre l'altro è legato a gravi effetti teratogeni, risultando in malformazioni alla nascita se assunto durante la gravidanza. A causa di questi rischi, Talidomide è stato ritirato dal mercato all'inizio degli anni '60. Tuttavia, da allora è stato riutilizzato ed è ora usato sotto rigorose regolamentazioni per il trattamento di determinate condizioni, come il mieloma multiplo e le complicazioni correlate alla lebbra. Il suo uso è attentamente monitorato a causa dei potenziali effetti collaterali, inclusa la neuropatia periferica e eventi tromboembolici.

Formula: C₁₃H₁₀N₂O₄

InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChI key: InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N

SMILES: O=C1N(C(=O)C=2C1=CC=CC2)C3C(=O)NC(=O)CC3

Sinonimi:

• 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
• 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
• 2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione
• 2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)isoindole-1,3-dione
• 2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione
• 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
• 2-Phthalimidoglutarimide
• 3-Phthalimidoglutarimide
• Celgene
• Contergan
• Distaval
• Immunoprin
• K 17
• Kevadon
• Myrin
• N-(2,6-Dioxo-3-piperidinyl)phthalimide
• N-(2,6-Dioxo-3-piperidyl)phthalimide
• N-Phthaloylglutamimide
• Neurosedyn
• Nsc 527179
• Nsc 66847
• Pantosediv
• Pharmion
• Phthalimide, N-(2,6-dioxo-3-piperidyl)-
• Quetimid
• Sauramide
• Sedalis
• Sedoval
• Softenil
• Softenon
• Suaramide
• Synovir
• Talidomida
• Talimol
• Talinol
• Thaled
• Thalidomid
• Thalomid
• α-(N-Phthalimido)glutarimide
• α-N-Phthalylglutaramide

(±)-Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Purezza: >98.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 258.23

Ref: 3B-T2524

(+/-)-Thalidomide, 99+%

CAS: 50-35-1

Teratogenic compound found to inhibit HIV-1 replication and FGF-induced angiogenesis

Formula: C₁₃H₁₀N₂O₄

Purezza: 99+%

Colore e forma: White to cream, Powder

Peso molecolare: 258.23

Ref: 02-J62266

Thalidomide

CAS: 50-35-1

Teratogenic compound found to inhibit HIV-1 replication and FGF-induced angiogenesis

Formula: C₁₃H₁₀N₂O₄

Peso molecolare: 258.23

Ref: 02-J60271

Thalidomide

CAS: 50-35-1

Imides and their derivatives (excluding sacharin), and salts thereof

Formula: C₁₃H₁₀N₂O₄

Colore e forma: White Off-White Powder

Peso molecolare: 258.06406

Ref: 45-1652500

Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 258.2295

Ref: IN-DA006UNO

Thalidomide

CAS: 50-35-1

Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.

Formula: C₁₃H₁₀N₂O₄

Purezza: 98.88% - 99.88%

Colore e forma: White Solid

Peso molecolare: 258.23

Ref: TM-T0213

Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 258.23

Ref: 4Z-T-232

Thalidomide

CAS: 50-35-1

Thalidomide

Purezza: ≥98%

Peso molecolare: 258.23g/mol

Ref: 54-BUP17698

Thalidomide-d4

CAS: 50-35-1

Formula: C₁₃H₆D₄N₂O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 262.26

Ref: 4Z-T-231

Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Purezza: ≤ 0.1%

Colore e forma: White to off-white powder

Peso molecolare: 258.23

Ref: 7W-GP4232

Thalidomide

CAS: 50-35-1

Thalidomide

Purezza: 98%

Peso molecolare: 258.23g/mol

Ref: 54-OR1029278

Thalidomide

Prodotto controllato

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Colore e forma: Neat

Peso molecolare: 258.23

Ref: 86-MM0940.00

(±)-Thalidomide

CAS: 50-35-1

Formula: C₁₃H₁₀N₂O₄

Peso molecolare: 258.23

Ref: ST-EA-CP-P25030

(+/-)-Thalidomide - Bio-X ™

Prodotto controllato

CAS: 50-35-1

Thalidomide is a piperidinyl isoindole drug that is used to treat various cancers such as myeloma and erythema nodosum leprosum. This drug is immunosuppressive and has anti-angiogenic activity. Thalidomide’s mechanism of action is not fully understood however it is thought to block the activity of tumor necrosis factor-alpha (TNF-α).

Formula: C₁₃H₁₀N₂O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 258.23 g/mol

Ref: 3D-BT164465

(+/-)-Thalidomide

Prodotto controllato

CAS: 50-35-1

Classified as immunomodulatory drug, thalidomide suppresses the expression of tumor necrosis factor-alpha (TNF-α), interferes with a cascade of pro-inflammatory cytokines, and interferes with the secretion of vascular endothelial growth factor (VEGF) and beta fibroblast growth factor (bFGF). Similarly to apremilast, thalidomide carries a phthalimide ring, together with a glutarimide ring that is specifically recognized by the target molecule cereblon. Thanks to its ability to contrast neoangiogenesis and the modifications of the bone marrow stromal microenvironment, thalidomide is a powerful tool to fight hematologic cancers. In the treatment of SARS-CoV-2, the immunomodulatory and anti-inflammatory action of thalidomide has and has proved beneficial when combined with a low-dose glucocorticoid.

Formula: C₁₃H₁₀N₂O₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 258.23 g/mol

Ref: 3D-FT15648

(+/-)-Thalidomide

CAS: 50-35-1

M02554 - (+/-)-Thalidomide

Formula: C₁₃H₁₀N₂O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 258.233

Ref: 10-M02554

Thalidomide

Prodotto controllato

CAS: 50-35-1

Applications Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)

Formula: C₁₃H₁₀N₂O₄

Colore e forma: Neat

Peso molecolare: 258.23

Ref: TR-T338850

Thalidomide

CAS: 50-35-1

Colore e forma: Neat

Ref: 61-FOR0940.00