CAS 50-63-5

(±)-Dihidrogenofosfato di clorochina

Descrizione:

(±)-Dihidrogenofosfato di clorochina è un composto sintetico conosciuto principalmente per il suo utilizzo come agente antimalarico. Appartiene alla classe delle 4-aminochinoline ed è caratterizzato dalla sua capacità di interferire con la crescita del parassita della malaria inibendo la polimerizzazione dell'eme, fondamentale per la sopravvivenza del parassita. Il composto presenta una natura chirale, con due enantiomeri, che possono influenzare la sua attività farmacologica e gli effetti collaterali. Oltre alle sue proprietà antimalariche, la clorochina è stata studiata per i potenziali effetti antivirali e come agente immunomodulatore in varie malattie autoimmuni. La forma di sale di difosfato ne migliora la solubilità e stabilità in soluzioni acquose, rendendola adatta per formulazioni farmaceutiche. La clorochina viene tipicamente somministrata per via orale e ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno in alcuni casi. Tuttavia, il suo utilizzo è stato associato a effetti collaterali, tra cui disturbi gastrointestinali e potenziale tossicità retinica con uso a lungo termine. Come per qualsiasi farmaco, è essenziale considerare attentamente i suoi benefici e rischi in contesti clinici.

Formula: C₁₈H₃₂ClN₃O₈P₂

InChI: InChI=1/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key: InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N

SMILES: P(=O)(O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinonimi:

• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-, phosphate (1:2)
• 3377 Rp
• 3377Rp
• 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
• 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
• 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
• Ai3-14952
• Alermine
• Alexoquine
• Aralen diphosphate
• Aralen phosphate
• Arechin
• Avloclor
• Bemaphate
• Chingamin
• Chingamin phosphate
• Chlorochin diphosphate
• Chloroquin diphosphate
• Chloroquine bis(phosphate)
• Chloroquine dihydrogen phosphate (1:2)
• Chloroquine phosphate
• Cidoquine
• Delagil
• Gontochin phosphate
• Imagon
• Khingamin
• Maladrin
• Malaquin
• NSC 14050
• Nivaquine B
• N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine phosphate (1:2)
• Quingamine
• Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, phosphate (1:2) (8CI)
• Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, diphosphate
• Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-, phosphate (1:2)
• Quivaclor
• Resochin
• Resoquine
• Sanoquin
• Sn 7618
• Tanakan
• Tanakan (antimalarial)
• Tresochin
• Unii-6E17K3343P
• Wr 1522
• chloroquin Phosphate
• dl-Chloroquine diphosphate
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2)
• 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-quinolindiphosphate
• 7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID
• N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE SALT
• gontochinphosphate
• chingaminphosphate
• klorokinfosfat
• h-stadur
• CHLOROQUINE DIPHOSPHATE SALT
• chloroquindiphosphate
• 7-chloro-4-((4’-diethylamino-1-methylbutyl)amino)quinolinediphosphate
• chloroquinebis(phosphate)
• aralendiphosphate
• N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIMETHYL-1,4-PENTANEDIAMINE DIPHOSPHATE
• n-(7-chloro-4-quinolinyl)-n,n-dimethyl-1,4-pentanediamine diphosphate salt

Chloroquine Diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃·2H₃PO₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 515.86

Ref: 3B-C2301

Chloroquine diphosphate salt, 98%

CAS: 50-63-5

Chloroquine diphosphate salt, 50-63-5, is a non-steroidal agent and DNA intercalator which exhibits antimalarial and anti-inflammatory properties. Learn more.

Formula: C₁₈H₃₂ClN₃O₈P₂

Purezza: 98%

Colore e forma: Powder or crystals or crystalline powder, White to off-white

Peso molecolare: 515.86

Ref: 02-J64459

Chloroquine Phosphate

CAS: 50-63-5

Colore e forma: Neat

Ref: 61-FOR1055.00

CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS

CAS: 50-63-5

CHLOROQUINE PHOSPHATE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002448

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate

Formula: C₁₈H₂₆ClN₃H₃PO₄

Purezza: 98.4%

Colore e forma: Light Brown

Peso molecolare: 417.15842

Ref: 47-1314

Chloroquine Phosphate

CAS: 50-63-5

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Formula: C₁₈H₂₆ClN₃·2H₃PO₄

Colore e forma: Yellow Powder

Peso molecolare: 515.86

Ref: 45-1118000

Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)

CAS: 50-63-5

Formula: C₁₈H₃₀ClN₃O₇P₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 497.8472

Ref: IN-DA0034LP

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.

Formula: C₁₈H₂₆CLN₃·2(H₃PO₄)

Purezza: 99.64% - ≥95%

Colore e forma: White To Slightly Yellow Crystalline Powder White Solid

Peso molecolare: 515.87

Ref: TM-T0194

Chloroquine diphosphate salt

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃·2H₃PO₄

Purezza: (Titration) 98.0 - 102.0 % (dried basis)

Colore e forma: White or almost white crystalline powder

Peso molecolare: 515.87

Ref: 7W-GA7477

Chloroquine phosphate

CAS: 50-63-5

Chloroquine phosphate

Purezza: ≥95%

Peso molecolare: 515.87g/mol

Ref: 54-BUP17400

Chloroquine Diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃·2H₃O₄P

Colore e forma: White To Off-White Solid

Peso molecolare: 319.88 2*97.99

Ref: 4Z-C-921

Chloroquine-d5 Diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₁D₅ClN₃·2H₃O₄P

Colore e forma: White To Off-White Solid

Peso molecolare: 324.91 2*97.99

Ref: 4Z-C-922

Chloroquine Phosphate

CAS: 50-63-5

Colore e forma: Neat

Ref: 86-MM1055.00

Chloroquine diphosphate

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃H₃O₄P

Colore e forma: Neat

Peso molecolare: 515.86

Ref: 04-C11506000

Chloroquine diphosphate

CAS: 50-63-5

Chloroquine diphosphate

Peso molecolare: 515.86g/mol

Ref: 54-BISN0106

Chloroquine-d4 Phosphate Salt

Prodotto controllato

CAS: 1246815-14-4, 50-63-5

Applications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.
References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),

Formula: C₁₈H₂₂D₄ClN₃•xH₃PO₄

Colore e forma: Yellow Solid

Peso molecolare: 323.9098

Ref: TR-C379967

Chloroquine diphosphate salt

CAS: 50-63-5

Stability Hygroscopic
Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product.
References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),

Formula: C₁₈H₂₆ClN₃·2H₃O₄P

Colore e forma: Light Brown

Peso molecolare: 515.86

Ref: TR-C379965

Chloroquine Diphosphate Salt

CAS: 50-63-5

Formula: C₁₈H₂₆ClN₃(H₃PO₄)

Peso molecolare: 319.9 : 2(98.0)

Ref: ST-EA-CP-C69001

Chloroquine Diphosphate

CAS: 50-63-5

Formula: C₁₈H₃₂ClN₃O₈P₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 515.86

Ref: 10-F358020

Chloroquine diphosphate

Prodotto controllato

CAS: 50-63-5

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine i a schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the S-glycoprotein.

Formula: C₁₈H₃₂ClN₃O₈P₂

Colore e forma: White Off-White Powder

Peso molecolare: 515.86 g/mol

Ref: 3D-FC20382