CAS 508-77-0

Cimarina

Descrizione:

Cimarina, con il numero CAS 508-77-0, è un composto chimico classificato come glicoside cardiaco, derivato principalmente dalla specie vegetale Digitalis purpurea, comunemente nota come digitale. Presenta una struttura caratterizzata da un nucleo steroideo con un anello di lattone, tipico dei glicosidi. Cimarina è noto per i suoi effetti farmacologici, in particolare per la sua capacità di influenzare la funzione cardiaca aumentando la forza delle contrazioni del cuore e regolando il ritmo cardiaco, rendendolo rilevante nel trattamento di alcune condizioni cardiache. Il composto agisce inibendo l'enzima Na+/K+ ATPasi, portando a un aumento dei livelli di calcio intracellulare nelle cellule cardiache. Oltre ai suoi usi terapeutici, Cimarina può essere tossico a dosi elevate, portando a sintomi come nausea, vomito e aritmie. Il suo uso è attentamente monitorato in contesti clinici ed è essenziale considerare le potenziali interazioni con altri farmaci. In generale, Cimarina esemplifica la doppia natura di molti composti naturali, offrendo sia benefici terapeutici che rischi.

Formula: C₃₀H₄₄O₉

InChI: InChI=1/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22+,23+,25+,26-,27-,28+,29+,30+/m1/s1

InChI key: InChIKey=XQCGNURMLWFQJR-ZNDDOCHDSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@]1(O)C[C@@H](O[C@H]6C[C@H](OC)[C@H](O)[C@@H](C)O6)CC2)[H])[H]

Sinonimi:

• (3beta,5beta)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta)-3-[(2,6-dideoxy-3-O-methylhexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8alpha)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8xi,9xi,10xi,13xi,14xi,17xi)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3β,5β)-3-[(2,6-Dideoxy-3-O-methyl-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Alvonal MR
• Card-20(22)-enolide, 3-[(2,6-dideoxy-3-O-methyl-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• Cymarine
• K-Strophanthin-α
• NSC 7522
• Strophantin K
• WV 90043a
• (+)-Cymarin
• Card-20(22)-enolide, 3-[(2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• (3β,5β)-3-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Cymarin
• (3beta,5beta)-3-[(2,6-dideoxy-4-O-beta-D\-glucopyranosyl-3-O-methyl-beta-D\-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• KOMBETIN
• STROPHANTHIN K
• CYMARIN: TECH., 90%
• K-STROPHANTHIN-ALPHA
• strofantidinacimaroside
• K-STROPHANTHIDIN-D-CYMAROSIDE
• 3β-[(3-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide
• CIMARIN
• K STROPHANTHIN
• CYMARIN CRYSTALLINE
• CYMARIN(P)
• 5-beta-card-20(22)-enolide,3-beta-(beta-d-cymarosyloxy)-5,14-dihydroxy-19-ox
• alvonalmr
• 3β-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β,14β-card-20(22)-enolide

Cymarin

CAS: 508-77-0

Cymarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₃₀H₄₄O₉

Purezza: (HPLC) ≥90%

Colore e forma: Powder

Peso molecolare: 548.67

Ref: 11-0809

Cymarin

CAS: 508-77-0

Natural glycoside

Formula: C₃₀H₄₄O₉

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 548.68

Ref: 5G-89838

Cymarin

Prodotto controllato

CAS: 508-77-0

Applications Cymarin is a pure allelochemicals that is a potent growth inhibitor in plants.
References Akhtar, Y.,e t al.: J. Appl. Entomol., 128, 32 (2004);

Formula: C₃₀H₄₄O₉

Colore e forma: Neat

Peso molecolare: 548.66

Ref: TR-C989908

Cymarin

CAS: 508-77-0

Cymarin is a cardiac glycoside, which is a class of organic compounds commonly derived from certain plant species, notably within the family Apocynaceae. It is extracted primarily from the plant *Apocynum cannabinum* and related species. Cymarin functions by inhibiting the sodium-potassium ATPase pump on cellular membranes. This inhibition leads to an increase in intracellular sodium levels, which in turn affects calcium exchange and enhances cardiac muscle contraction. This mode of action makes it a potent inotropic agent.

Formula: C₃₀H₄₄O₉

Purezza: Min. 95%

Peso molecolare: 548.66 g/mol

Ref: 3D-FC156960

Cymarin

CAS: 508-77-0

Cymarin is a natural product for research related to life sciences. The catalog number is TN3746 and the CAS number is 508-77-0.

Formula: C₃₀H₄₄O₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 548.67

Ref: TM-TN3746