CAS 51-21-8

5-Fluorouracile

Descrizione:

5-Fluorouracile (5-FU) è un analogo di pirimidina sintetico che funge da antimetabolita nel trattamento del cancro, mirando principalmente a cellule che si dividono rapidamente. La sua formula chimica è C4H3FN2O2 ed è caratterizzata dalla presenza di un atomo di fluoro nella posizione 5 dell'anello dell'uracile, che altera i suoi percorsi metabolici. Il 5-FU viene tipicamente somministrato per via endovenosa o topica, a seconda del tipo di cancro trattato, come il cancro colorettale, al seno e della pelle. Il meccanismo d'azione implica l'inibizione della timidilato sintasi, portando a una deplezione di trifosfato di timidina e, in ultima analisi, interrompendo la sintesi e la riparazione del DNA. 5-Fluorouracile è noto per i suoi effetti collaterali, che possono includere disturbi gastrointestinali, mielosoppressione e mucosite, a causa del suo impatto sulle cellule normali che si dividono rapidamente. La sua efficacia può essere migliorata quando utilizzata in combinazione con altri agenti chemioterapici. Come potente agente chemioterapico, il 5-FU rimane un componente critico nella farmacoterapia oncologica.

Formula: C₄H₃FN₂O₂

InChI: InChI=1/C4H3FN2O2/c5-7-2-1-3(8)6-4(7)9/h1-2H,(H,6,8,9)

InChI key: InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N

SMILES: O=C1C(F)=CNC(=O)N1

Sinonimi:

• 1-fluoropyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
• 2,4-Dihydroxy-5-fluoropyrimidine
• 2,4-Dioxo-5-fluoropyrimidine
• 5-Fluoracyl
• 5-Fluoro Uracil
• 5-Fluoro-1H-pyrimidine-2,4-dione
• 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• 5-Fluoro-2,4-(1H,3H)-pyrimidindion
• 5-Fluoro-2,4-Pyrimidinedione
• 5-Fluoro-2,4-dihydroxypyrimidine
• 5-Fluoropyrimidine-2,4-Dione
• 5-Fluoropyrimidine-2,4-diol
• 5-Fluoruracil
• 5-Fu
• 5-Oncouracil
• Adrucil
• Arumel
• Carac
• Carzonal
• Efudex
• Efudix
• Efurix
• FU
• Fluoracil
• Fluoroblastin
• Fluoroplex
• Fluorouracil
• Fluorouracil, 5-
• Fluorouracile
• Fluorouracile Accord
• Fluorouracilo
• Fluorouracilum
• Fluoruracil
• Flurablastin
• Fluracedyl
• Fluracil
• Fluracilum
• Fluri
• Fluril
• Ftoruracil
• Kecimeton
• Nsc 19893
• Phthoruracil
• Phtoruracil
• Queroplex
• Ro 2-9757
• Sigma 03738
• Tegadifure
• Timazin
• U 8953
• Ulup
• Uracil, 5-Fluoro-
• 5-faracil
• 3h)-pyrimidinedione,5-fluoro-4(1h
• 5-FLUOROURACIL
• 5-Fluor-2,4-dihydroxypyrimidin
• 1-FLUORO-1H-PYRIMIDINE-2,4-DIONE
• 5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
• 5-fluor-2,4(1h,3h)-pyrimidindion
• [180]-5-Fluorouracil

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purezza: >99.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 130.08

Ref: 3B-F0151

5-Fluorouracil, 99%

CAS: 51-21-8

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses

Formula: C₄H₃FN₂O₂

Purezza: 99%

Colore e forma: Crystalline powder, White to pale cream

Peso molecolare: 130.08

Ref: 02-A13456

Fluorouracil

CAS: 51-21-8

Fluorouracil

Colore e forma: White

Ref: 47-995

FLUOROURACIL RS

CAS: 51-21-8

FLUOROURACIL RS

Formula: C₄H₃FN₂O₂

Peso molecolare: 130.0772

Ref: 41-ICRS0312

FLUOROURACIL CRS

CAS: 51-21-8

FLUOROURACIL CRS

Colore e forma: Added Modified

Ref: 41-F0250000

Fluorouracil

CAS: 51-21-8

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₄H₃FN₂O₂

Colore e forma: White Off-White Powder

Peso molecolare: 130.01786

Ref: 45-1279000

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis.

Formula: C₄H₃FN₂O₂

Purezza: 98% - >99.99%

Colore e forma: White Solid

Peso molecolare: 130.08

Ref: TM-T0984

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Formula: C₄H₃FN₂O₂

Purezza: ≥98%

Peso molecolare: 130.08

Ref: 54-BUP17413

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Formula: C₄H₃FN₂O₂

Purezza: 99%

Colore e forma: White Solid-Powder

Peso molecolare: 130.07722

Ref: 54-PC4380

5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 130.0772

Ref: IN-DA003MRU

Fluorouracil-13C-15N2

CAS: 51-21-8

Formula: C₃₁₃CH₃F₁₅N₂O₂

Colore e forma: Pale Yellow Solid

Peso molecolare: 133.06

Ref: 4Z-F-532

Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 130.08

Ref: 4Z-F-536

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purezza: ≥ 99.0%

Colore e forma: White to almost white crystalline powder

Peso molecolare: 130.08

Ref: 7W-GP6168

5-Fluorouracil-15N2

CAS: 51-21-8, 68941-95-7

Purezza: 98 atom % 15N

Colore e forma: White Solid

Peso molecolare: 132.10

Ref: 3U-N2140

Fluorouracil

CAS: 51-21-8

Colore e forma: Neat

Ref: 61-FOR0593.00

Fluorouracil

CAS: 51-21-8

Colore e forma: Neat

Ref: 86-MM0593.00

5-Fluorouracil (Standard)

CAS: 51-21-8

5-Fluorouracil (Standard) is a reference standard for research and analysis in studies involving 5-Fluorouracil. 5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis and autophagy.

Formula: C₄H₃FN₂O₂

Colore e forma: Solid

Peso molecolare: 130.08

Ref: TM-TMSM-3471

5-Fluorouracil

Prodotto controllato

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Colore e forma: Neat

Peso molecolare: 130.08

Ref: 04-C13799500

5-Fluorouracil

CAS: 51-21-8

5-Fluoropyrimidine-2,4(1H,3H)-dione

Formula: C₄H₃FN₂O₂

Purezza: 98%

Peso molecolare: 130.08

Ref: IN-DG9397

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Formula: C₄H₃FN₂O₂

Purezza: 99%

Colore e forma: White Solid-Powder

Peso molecolare: 130.07722

Ref: 54-BIF0123

5-Fluoro Uracil

Prodotto controllato

CAS: 51-21-8

Impurity Flucytosine EP Impurity A
Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);

Formula: C₄H₃FN₂O₂

Colore e forma: Neat

Peso molecolare: 130.08

Ref: TR-F596000

5-Fluorouracil - Bio-X ™

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death.

Formula: C₄H₃FN₂O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 130.08 g/mol

Ref: 3D-BF166014

Flucytosine EP Impurity A

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Peso molecolare: 130.1

Ref: ST-EA-CP-F3001

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 130.078

Ref: 10-F003241

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug used to treat cancer. It is a prodrug that is converted to 5-fluoro-2'-deoxyuridine 5'-triphosphate (5-FUdR) in cells, and inhibits RNA synthesis by interacting with the enzyme thymidylate synthase. This drug has minimal toxicity in humans and has shown promising results against wild-type strains of bacteria. 5-Fluorouracil also has demonstrated synergistic activity when combined with the taxane docetaxel in the treatment of non-small cell lung cancer. 5-Fluorouracil's oral prodrug, fluorouracil, can be administered as an alternative to intravenous administration. The drug is found in many pharmaceutical preparations, including benzalkonium chloride wipes, which are used as topical agents for skin disinfection before surgery or other medical procedures. Blood samples may be drawn from patients who have been

Formula: C₄H₃FN₂O₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 130.08 g/mol

Ref: 3D-FF05372

Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Peso molecolare: 130.1

Ref: ST-EA-CP-F32000

5-Fluorouracil (5-FU) Exiplus, Multi-Compendial, 99%

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purezza: min. 99%

Colore e forma: White to off white, Crystalline powder, Clear, Colourless

Peso molecolare: 130.08

Ref: SR-59333

5-Fluorouracil (5-FU) extrapure, 99%

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purezza: min. 99%

Colore e forma: White to off white, Crystalline powder, Clear, Colourless

Peso molecolare: 130.08

Ref: SR-15088