CAS 5119-48-2

Withaferin A

Descrizione:

Withaferin A è una lattone esteroidea che si verifica naturalmente ed è derivata dalla pianta Withania somnifera, comunemente nota come ashwagandha. È classificata come un withanolide, che è un tipo di composto noto per le sue diverse attività biologiche. Withaferin A presenta una gamma di proprietà farmacologiche, inclusi effetti anti-infiammatori, anti-cancro e neuroprotettivi. Il suo meccanismo d'azione coinvolge la modulazione di varie vie di segnalazione, inclusa l'inibizione del fattore nucleare kappa B (NF-κB) e l'induzione dell'apoptosi nelle cellule tumorali. Il composto è anche noto per il suo potenziale di migliorare la risposta immunitaria e mostrare proprietà antiossidanti. Withaferin A è tipicamente studiato nel contesto della medicina tradizionale e della farmacologia moderna, e il suo potenziale terapeutico è in fase di esplorazione in varie malattie, incluso il cancro e i disturbi neurodegenerativi. Tuttavia, sono necessarie ulteriori ricerche per comprendere appieno la sua efficacia e sicurezza nelle applicazioni cliniche.

Formula: C₂₈H₃₈O₆

InChI: InChI=1/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChI key: InChIKey=DBRXOUCRJQVYJQ-CKNDUULBSA-N

SMILES: C[C@]12[C@]3([C@](O3)(C[C@@]4([C@@]1(CC[C@@]5(C)[C@]4(CC[C@@]5([C@H](C)[C@]6(CC(C)=C(CO)C(=O)O6)[H])[H])[H])[H])[H])[H])[C@@H](O)C=CC2=O

Sinonimi:

• (4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone
• 4b,27-Dihydroxy-1-oxo-5b,6b-epoxywitha-2,24-dienolide
• 5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone
• 5,6-Epoxy-5H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv.
• 5β-Ergosta-2,24-dien-26-oic acid, 5,6β-epoxy-4β,22,27-trihydroxy-1-oxo-, δ-lactone, (20S,22R)-
• Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, δ-lactone, (4β,5β,6β,22R)-
• NSC 101088
• NSC 273757
• Withaferin A
• Withaferine
• Withaferine A
• withaferinea
• Withaferin A NSC 273757 NSC 101088
• Withaferin A from leaves of Withania somnifera
• 2,24-dien-26-oic Acid δ-Lactone
• 5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid
• (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone
• (20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta-
• Withaferin A 5119-48-2
• 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
• Withaferin A Standard
• Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
• Ergosta-2,24-dien-26-oicacid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, d-lactone, (4b,5b,6b,22R)-

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 470.5977

Ref: IN-DA00DCXC

WITHAFERIN A

CAS: 5119-48-2

WITHAFERIN A

Purezza: ≥95%

Peso molecolare: 470.6g/mol

Ref: 54-BUP12713

Withaferin A

CAS: 5119-48-2

Withaferin A

Formula: C₂₈H₃₈O₆

Purezza: By hplc: 99.01% (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 470.60g/mol

Ref: 54-BIW4202

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Colore e forma: Neat

Peso molecolare: 470.60

Ref: 04-C17942200

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Purezza: 95%~99%

Peso molecolare: 470.606

Ref: BP-BP4186

WITHAFERIN A

CAS: 5119-48-2

WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/

Formula: C₂₈H₃₈O₆

Purezza: 97.41% - 99.99%

Colore e forma: Solid

Peso molecolare: 470.60

Ref: TM-T5687

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Purezza: ≥ 95.0%

Colore e forma: White to light yellow powder

Peso molecolare: 470.61

Ref: 7W-GY6190

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Peso molecolare: 470.61

Ref: 4Z-W-011001

Withaferin a

CAS: 5119-48-2

Lactone

Formula: C₂₈H₃₈O₆

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 470.61

Ref: 5G-89824

Withaferin A

CAS: 5119-48-2

Withaferin A is a bioactive compound, which is a steroidal lactone with antiproliferative properties. It is derived from the medicinal plant *Withania somnifera*, commonly known as Ashwagandha. Withaferin A exerts its effects by modulating various signaling pathways, including the inhibition of NF-kB and induction of oxidative stress, which lead to apoptotic cell death in cancer cells and reduced inflammation.

Formula: C₂₈H₃₈O₆

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 470.6 g/mol

Ref: 3D-FW32226

Withaferin A

CAS: 5119-48-2

Applications Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).
References Shohat, B., et al.: Cancer Chemother. Rep., 51, 271 (1967), Shohat, B., et al.: Int. J. Cancer., 8, 487 (1971); Chem. and Eng. News p. 6, Aug. 8, 2016

Formula: C₂₈H₃₈O₆

Colore e forma: White Solid

Peso molecolare: 470.60

Ref: TR-W499200

Deuterated Withaferin A Deuterated

Prodotto controllato

CAS: 5119-48-2

Formula: C₂₈H₃₅D₃O₆

Colore e forma: Neat

Peso molecolare: 470.60 (Unlabelled)

Ref: TR-W499202