CAS 51627-14-6

Cefatrizina

Descrizione:

Cefatrizina è un antibiotico sintetico appartenente alla classe delle cefalosporine, utilizzato principalmente per le sue proprietà battericide contro una gamma di batteri Gram-positivi e Gram-negativi. Funziona inibendo la sintesi della parete cellulare batterica, portando alla lisi cellulare e alla morte. Cefatrizina è caratterizzato dalla sua struttura a beta-lattame, essenziale per la sua attività antimicrobica. Il composto viene solitamente somministrato per via orale ed è noto per il suo spettro relativamente ampio di attività, rendendolo efficace nel trattamento di varie infezioni, comprese le infezioni respiratorie e del tratto urinario. La sua farmacocinetica implica l'assorbimento nel tratto gastrointestinale, con distribuzione nei tessuti corporei. Il farmaco è generalmente ben tollerato, sebbene gli effetti collaterali potenziali possano includere disturbi gastrointestinali e reazioni allergiche, in particolare in individui con una storia di allergie alla penicillina. Come per altri antibiotici, un uso appropriato è cruciale per minimizzare lo sviluppo di resistenza agli antibiotici. In generale, Cefatrizina rappresenta un'opzione importante nell'arsenale delle terapie antimicrobiche, in particolare in contesti in cui le cefalosporine sono indicate.

Formula: C₁₈H₁₈N₆O₅S₂

InChI: InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1

InChI key: InChIKey=UOCJDOLVGGIYIQ-PBFPGSCMSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C2=O)(SCC1CSC4=CN=NN4)[H]

Sinonimi:

• (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-5-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(2H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[amino(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(2H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1H-1,2,3-Triazole, 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid deriv.
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-5-ylthio)methyl]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-, [6R-[6α,7β(R*)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-5-ylthio)methyl]-,(6R,7R)-
• 7-[2-(4-Hydroxyphenyl)-2-Aminoacetamido]-3-(1,2,3-Triazole-4-Ylthio)Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• 7-[<span class="text-smallcaps">D</span>-α-Amino-α-(4-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
• 7-{[amino(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(2H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Antibiotic BL-S 640
• Antibioticbl-640
• Antibioticbl-S640
• Bl-S 640
• Bls640
• Cefaperos
• Cephatriazine
• Cephatrizin
• Cephatrizine
• Cepticol
• Eta(R)))-
• Eta(R)))- L)Acetyl)Amino)-8-Oxo-3-((1H-1,2,3-Triazol-4-Ylthio)Methyl)-,(6R-(6-Alpha,7-B
• S 640P
• S640P

Cefatrizine

CAS: 51627-14-6

Ref: 7W-GA7632

Cefatrizine

CAS: 51627-14-6

Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.

Formula: C₁₈H₁₈N₆O₅S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 462.5

Ref: TM-T26973

Cefatrizine

CAS: 51627-14-6

Cefatrizine is a broad-spectrum antibiotic, which is a semisynthetic cephalosporin derived from cephalosporin C, a natural product originating from the fungus Acremonium chrysogenum. It exerts its mode of action through the inhibition of bacterial cell wall synthesis, a critical component for bacterial growth and replication. Specifically, cefatrizine targets and binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, leading to the inhibition of peptidoglycan synthesis. This disruption results in cell lysis and ultimately bacterial cell death.

Formula: C₁₈H₁₈N₆O₅S₂

Purezza: Min. 95%

Peso molecolare: 462.5 g/mol

Ref: 3D-AC37979

Cefatrizine

Prodotto controllato

CAS: 51627-14-6

Applications Cefatrizine is a new orally administered cephalosporin with excellent activity against gram-positive cocci, inhibiting all except enterococci at minimal inhibitory concentrations below 1 μg/ml.
References Harold, C. N., et al.: Antimicrob, Agents. Chemother., 15, 209 (1979); Actor, P.J., et al.: J. Antibiot., 28, 594 (1975); Sharma, R.K., et al.: Asian. J. Biochem. Pharma. Res., 1, 443 (2011);

Formula: C₁₈H₁₈N₆O₅S₂

Colore e forma: Neat

Peso molecolare: 462.503

Ref: TR-C237575

Cefatrizine-d4

Prodotto controllato

CAS: 51627-14-6

Formula: C₁₈D₄H₁₄N₆O₅S₂

Colore e forma: Neat

Peso molecolare: 466.527

Ref: TR-C237577