CAS 51773-92-3

Cloridrato di meflochina

Descrizione:

Cloridrato di meflochina è un farmaco antimalarico utilizzato principalmente per la prevenzione e il trattamento della malaria, in particolare nelle aree in cui la resistenza ad altri farmaci antimalarici è prevalente. È un composto sintetico appartenente alla classe delle chinoline ed è caratterizzato dalla sua capacità di interferire con la crescita del parassita della malaria all'interno dei globuli rossi. La sostanza appare come una polvere cristallina bianca o bianco sporco ed è solubile in acqua, il che facilita la sua somministrazione per via orale. Cloridrato di meflochina ha una emivita relativamente lunga, consentendo una somministrazione settimanale nei regimi profilattici. Tuttavia, è associato a una serie di potenziali effetti collaterali, inclusi sintomi neuropsichiatrici, che possono limitarne l'uso in alcune popolazioni. Il meccanismo d'azione del composto implica l'inibizione della polimerizzazione dell'eme, portando all'accumulo di eme tossico all'interno del parassita. A causa del suo profilo farmacologico specifico, Cloridrato di meflochina rimane un'opzione importante nella lotta globale contro la malaria, specialmente nelle regioni endemiche.

Formula: C₁₇H₁₆F₆N₂O·ClH

InChI: InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s2

InChI key: InChIKey=WESWYMRNZNDGBX-HFEUSWDWNA-N

SMILES: C(F)(F)(F)C=1C2=C(C([C@H](O)[C@]3(CCCCN3)[H])=CC(C(F)(F)F)=N2)C=CC1.Cl

Sinonimi:

• (2R)-(+/-)-alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
• (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride (1:1)
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel-
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (αS)-rel-
• 4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-
• Loriam
• Mefloquin hydrochloride
• Mefloquine Hcl
• NSC 157387
• Ro 21-5998/001
• Wr 142490
• [2,8-Bis(Trifluoromethyl)Quinolin-4-Yl](Piperidin-2-Yl)Methanol Hydrochloride (1:1)

Mefloquine Hydrochloride

CAS: 51773-92-3, 53230-10-7

Formula: C₁₇H₁₆F₆N₂O·HCl

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 414.78

Ref: 3B-M2313

Mefloquine Hydrochloride

CAS: 51773-92-3

Colore e forma: Neat

Ref: 61-FOR1198.00

MEFLOQUINE FOR SYSTEM SUITABILITY CRS

CAS: 51773-92-3

MEFLOQUINE FOR SYSTEM SUITABILITY CRS

Colore e forma: Modified

Ref: 41-Y0002421

MEFLOQUINE HYDROCHLORIDE CRS

CAS: 51773-92-3

MEFLOQUINE HYDROCHLORIDE CRS

Formula: C₁₇H₁₆F₆N₂O

Colore e forma: Added Modified

Peso molecolare: 378.3122

Ref: 41-M0253000

Mefloquine Hydrochloride

CAS: 51773-92-3

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₇H₁₆F₆N₂O·HCl

Colore e forma: White Powder

Peso molecolare: 378.11668

Ref: 45-1379059

4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel-

CAS: 51773-92-3

Formula: C₁₇H₁₇ClF₆N₂O

Purezza: %

Colore e forma: Solid

Peso molecolare: 414.7731

Ref: IN-DA00I991

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Formula: C₁₇H₁₇ClF₆N₂O

Purezza: 99% - 99.99%

Colore e forma: Off-White To Yellow Solid

Peso molecolare: 414.77

Ref: TM-T0860

(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride

CAS: 51773-92-3

(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride

Formula: C₁₇H₁₆F₆N₂O·ClH

Purezza: 99%

Colore e forma: white powder

Peso molecolare: 414.77g/mol

Ref: 54-PC404546

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine hydrochloride

Purezza: ≥98%

Peso molecolare: 414.77g/mol

Ref: 54-BUP13994

Mefloquine HCl

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·HCl

Peso molecolare: 378.32 36.46

Ref: 4Z-M-821

Mefloquine hydrochloride, BP, Ph. Eur., USP grade

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·HCl

Peso molecolare: 414.77

Ref: 7W-GP0681

Mefloquine hydrochloride

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·HCl

Purezza: ≥ 98.0%

Colore e forma: White to pale yellow crystalline powder

Peso molecolare: 414.77

Ref: 7W-GP7880

Mefloquine hydrochloride 100 µg/mL in Acetonitrile

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·ClH

Colore e forma: Single Solution

Peso molecolare: 414.77

Ref: 04-A14860900AL-100

Mefloquine Hydrochloride

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·ClH

Colore e forma: Neat

Peso molecolare: 414.77

Ref: 86-MM1198.00

Mefloquine Hydrochloride (d10 Major)

Prodotto controllato

CAS: 51773-92-3

Applications Labelled quinoline methanol antimalarial agent.
References Carroll, F.I., et al.: J. Med. Chem., 17, 210 (1974), Davidson, M.W., et al.: J. Med. Chem., 20, 1117 (1977), Brown, R.E., et al.: Life Sci., et al.: 25, 1857 (1979), Lim, P., et al.: Anal. Profiles Drug Subs., 14, 157 (1985),

Formula: C₁₇₂H₁₀H₆F₆N₂O·ClH

Colore e forma: Neat

Peso molecolare: 424.83

Ref: TR-M207053

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine is a drug that belongs to the class of pharmacological agents. It is used in the treatment of malaria caused by protozoa of the genus Plasmodium, which are transmitted by mosquitoes. Mefloquine is a metal chelate that inhibits the activity of p-glycoprotein, a membrane protein which controls the transport or efflux of many drugs from cells. This inhibition leads to an increase in the concentration of mefloquine inside bacteria and parasites, increasing its effectiveness at inhibiting their growth. Mefloquine has been shown to be effective in treating infectious diseases such as bowel disease and malaria caused by protozoa.
Mefloquine can cause toxic epidermal necrolysis, a condition where large areas of skin slough off and die if taken with certain other drugs (such as phenytoin).

Formula: C₁₇H₁₇ClF₆N₂O

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 414.77 g/mol

Ref: 3D-FP40600

Mefloquine hydrochloride

CAS: 51773-92-3

Formula: C₁₇H₁₇ClF₆N₂O

Purezza: 95.0%

Peso molecolare: 414.78

Ref: 10-F091687