CAS 52-01-7

Spironolattone

Descrizione:

Spironolattone è un composto steroideo sintetico utilizzato principalmente come diuretico e agente antipertensivo. Funziona come un antagonista dell'aldosterone, inibendo l'azione dell'aldosterone nei reni, il che promuove l'escrezione di sodio e acqua mentre conserva il potassio. Questo meccanismo lo rende efficace nel trattamento di condizioni come l'ipertensione, l'insufficienza cardiaca e alcuni casi di edema. Spironolattone è anche utilizzato nella gestione di condizioni come l'iperaldosteronismo e può essere utile nel trattamento dell'acne e dell'irsutismo grazie alle sue proprietà antiandrogeniche. Il composto è tipicamente somministrato per via orale e ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno in molti casi. In termini di struttura chimica, Spironolattone presenta un anello di lattone e un gruppo tioestere, contribuendo alla sua attività farmacologica. Gli effetti collaterali comuni possono includere iperkaliemia, disturbi gastrointestinali e squilibri ormonali. A causa dei suoi effetti ormonali, Spironolattone è talvolta utilizzato off-label nella terapia ormonale per individui transgender. In generale, Spironolattone è un farmaco versatile con significative applicazioni terapeutiche in varie condizioni mediche.

Formula: C₂₄H₃₂O₄S

InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

InChI key: InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Sinonimi:

• (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
• 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
• 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
• 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
• 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
• 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
• 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
• 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
• 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
• 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
• Abbolactone
• Aldace
• Aldactone
• Aldactone A
• Aldopur
• Almatol
• Altex
• Aquareduct
• Berlactone
• Deverol
• Diatensec
• Dira
• Duraspiron
• Espironolactona
• Euteberol
• Lacalmin
• Lacdene
• Laractone
• Nefurofan
• Novo-Spiroton
• Nsc 150399
• Osiren
• Osyrol
• Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
• Quimolactona
• S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
• S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• Sagisal
• Sc 9420
• Sincomen
• Spiresis
• Spiretic
• Spiridon
• Spiro-Tablinen
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
• Spiroctan
• Spiroderm
• Spirolactone
• Spirolang
• Spirolone
• Spirone
• Spironol
• Spironolacton
• Spironolactone A
• Supra-Puren
• Suracton
• Uractone
• Urusonin
• Verospiron
• Verospirone
• Xenalon

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 416.58

Ref: 3B-S0260

Spironolactone

CAS: 52-01-7

Spironolactone used as potassium sparing diuretic. Also used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation

Formula: C₂₄H₃₂O₄S

Colore e forma: White solid

Peso molecolare: 416.58

Ref: 02-J60119

Spironolactone 1.0 mg/ml in Acetonitrile

CAS: 52-01-7

Colore e forma: Single Solution

Ref: 61-AMP0197.00-11

Spironolactone

CAS: 52-01-7

Colore e forma: Neat

Ref: 61-FOR0197.00

SPIRONOLACTONE CRS

CAS: 52-01-7

SPIRONOLACTONE CRS

Formula: C₂₄H₃₂O₄S

Colore e forma: Powder

Peso molecolare: 416.5735

Ref: 41-S1200000

SPIRONOLACTONE RS

CAS: 52-01-7

SPIRONOLACTONE RS

Formula: C₂₄H₃₂O₄S

Colore e forma: Powder

Peso molecolare: 416.5735

Ref: 41-ICRS49241

Spironolactone

CAS: 52-01-7

Spironolactone

Formula: C₂₄H₃₂O₄S

Purezza: 99.3%

Colore e forma: Off-White

Peso molecolare: 416.20213

Ref: 47-306

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

CAS: 52-01-7

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

Colore e forma: Powder

Ref: 41-Y0001295

Spironolactone

CAS: 52-01-7

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₄H₃₂O₄S

Colore e forma: White Light Cream Powder

Peso molecolare: 416.20213

Ref: 45-1619006

Spironolactone

CAS: 52-01-7

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Formula: C₂₄H₃₂O₄S

Purezza: 99.87%

Colore e forma: White Powder

Peso molecolare: 416.57

Ref: TM-T0476

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Colore e forma: Off-White Solid

Peso molecolare: 416.58

Ref: 4Z-S-083

Spironolactone, Ph. Eur. grade

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: ≤ 0.1%

Colore e forma: White or pale yellow powder

Peso molecolare: 416.58

Ref: 7W-GP2110

Spironolactone-d3 (7-Acetylthio-d3)

CAS: 52-01-7

Formula: C₂₄H₂₉D₃O₄S

Peso molecolare: 419.59

Ref: 4Z-S-0823

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: (HPLC) ≥ 97.0%

Colore e forma: White to off-white powder

Peso molecolare: 416.58

Ref: 7W-GP5407

Spironolactone-d3 (Major)

CAS: 52-01-7

Formula: C₂₄H₂₉D₃O₄S

Colore e forma: Off-White To Pale Yellow Solid

Peso molecolare: 419.59

Ref: 4Z-S-082

Spironolactone

CAS: 52-01-7

Spironolactone

Purezza: ≥95%

Peso molecolare: 416.579g/mol

Ref: 54-OR98301

Spironolactone

Prodotto controllato

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Colore e forma: Neat

Peso molecolare: 416.57

Ref: 04-C16972980

Spironolactone

CAS: 52-01-7

Colore e forma: Neat

Ref: 86-MM0197.00

Sugammadex Impurity 77

CAS: 52-01-7

Formula: C₈₇H₁₁₄O₄₈PS₇·7Na

Colore e forma: Off-White To Pale Yellow Solid

Peso molecolare: 2183.22 7*22.99

Ref: 4Z-S-082080

Spironolactone RS

CAS: 52-01-7

Colore e forma: White

Ref: 2K-1074000021