CAS 52-01-7

Spironolattone

Descrizione:

Spironolattone è un composto steroideo sintetico utilizzato principalmente come diuretico e agente antipertensivo. Funziona come un antagonista dell'aldosterone, inibendo l'azione dell'aldosterone nei reni, il che promuove l'escrezione di sodio e acqua mentre conserva il potassio. Questo meccanismo lo rende efficace nel trattamento di condizioni come l'ipertensione, l'insufficienza cardiaca e alcuni casi di edema. Spironolattone è anche utilizzato nella gestione di condizioni come l'iperaldosteronismo e può essere utile nel trattamento dell'acne e dell'irsutismo grazie alle sue proprietà antiandrogeniche. Il composto è tipicamente somministrato per via orale e ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno in molti casi. In termini di struttura chimica, Spironolattone presenta un anello di lattone e un gruppo tioestere, contribuendo alla sua attività farmacologica. Gli effetti collaterali comuni possono includere iperkaliemia, disturbi gastrointestinali e squilibri ormonali. A causa dei suoi effetti ormonali, Spironolattone è talvolta utilizzato off-label nella terapia ormonale per individui transgender. In generale, Spironolattone è un farmaco versatile con significative applicazioni terapeutiche in varie condizioni mediche.

Formula: C₂₄H₃₂O₄S

InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

InChI key: InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Sinonimi:

• (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
• 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
• 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
• 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
• 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
• 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
• 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
• 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
• 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
• 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
• Abbolactone
• Aldace
• Aldactone
• Aldactone A
• Aldopur
• Almatol
• Altex
• Aquareduct
• Berlactone
• Deverol
• Diatensec
• Dira
• Duraspiron
• Espironolactona
• Euteberol
• Lacalmin
• Lacdene
• Laractone
• Nefurofan
• Novo-Spiroton
• Nsc 150399
• Osiren
• Osyrol
• Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
• Quimolactona
• S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
• S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• Sagisal
• Sc 9420
• Sincomen
• Spiresis
• Spiretic
• Spiridon
• Spiro-Tablinen
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
• Spiroctan
• Spiroderm
• Spirolactone
• Spirolang
• Spirolone
• Spirone
• Spironol
• Spironolacton
• Spironolactone A
• Supra-Puren
• Suracton
• Uractone
• Urusonin
• Verospiron
• Verospirone
• Xenalon

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 416.58

Ref: 3B-S0260

Spironolactone

CAS: 52-01-7

Spironolactone used as potassium sparing diuretic. Also used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation

Formula: C₂₄H₃₂O₄S

Colore e forma: White solid

Peso molecolare: 416.58

Ref: 02-J60119

Spironolactone 1.0 mg/ml in Acetonitrile

CAS: 52-01-7

Colore e forma: Single Solution

Ref: 61-AMP0197.00-11

Spironolactone

CAS: 52-01-7

Colore e forma: Off-White

Ref: 61-FOR0197.00

SPIRONOLACTONE CRS

CAS: 52-01-7

SPIRONOLACTONE CRS

Formula: C₂₄H₃₂O₄S

Colore e forma: Powder

Peso molecolare: 416.5735

Ref: 41-S1200000

SPIRONOLACTONE RS

CAS: 52-01-7

SPIRONOLACTONE RS

Formula: C₂₄H₃₂O₄S

Colore e forma: Powder

Peso molecolare: 416.5735

Ref: 41-ICRS49241

Spironolactone

CAS: 52-01-7

Spironolactone

Formula: C₂₄H₃₂O₄S

Purezza: 99.3%

Colore e forma: Off-White

Peso molecolare: 416.20213

Ref: 47-306

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

CAS: 52-01-7

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

Colore e forma: Powder

Ref: 41-Y0001295

Spironolactone

CAS: 52-01-7

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₄H₃₂O₄S

Colore e forma: White Light Cream Powder

Peso molecolare: 416.20213

Ref: 45-1619006

Spironolactone

CAS: 52-01-7

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Formula: C₂₄H₃₂O₄S

Purezza: 99.87%

Colore e forma: White Powder

Peso molecolare: 416.57

Ref: TM-T0476

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Colore e forma: Off-White Solid

Peso molecolare: 416.58

Ref: 4Z-S-083

Spironolactone, Ph. Eur. grade

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: ≤ 0.1%

Colore e forma: White or pale yellow powder

Peso molecolare: 416.58

Ref: 7W-GP2110

Spironolactone-d3 (7-Acetylthio-d3)

CAS: 52-01-7

Formula: C₂₄H₂₉D₃O₄S

Peso molecolare: 419.59

Ref: 4Z-S-0823

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: (HPLC) ≥ 97.0%

Colore e forma: White to off-white powder

Peso molecolare: 416.58

Ref: 7W-GP5407

Spironolactone-d3 (Major)

CAS: 52-01-7

Formula: C₂₄H₂₉D₃O₄S

Colore e forma: Off-White To Pale Yellow Solid

Peso molecolare: 419.59

Ref: 4Z-S-082

Spironolactone

CAS: 52-01-7

Spironolactone

Purezza: ≥95%

Peso molecolare: 416.579g/mol

Ref: 54-OR98301

Spironolactone

Prodotto controllato

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Colore e forma: Neat

Peso molecolare: 416.57

Ref: 04-C16972980

Spironolactone

CAS: 52-01-7

Colore e forma: Off-White

Ref: 86-MM0197.00

Sugammadex Impurity 77

CAS: 52-01-7

Formula: C₈₇H₁₁₄O₄₈PS₇·7Na

Colore e forma: Off-White To Pale Yellow Solid

Peso molecolare: 2183.22 7*22.99

Ref: 4Z-S-082080

Spironolactone RS

CAS: 52-01-7

Colore e forma: White

Ref: 2K-1074000021

Spironolactone-d3

Prodotto controllato

CAS: 52-01-7

Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975)

Formula: C₂₄H₂₉D₃O₄S

Colore e forma: Yellow Solid

Peso molecolare: 419.59

Ref: TR-S683003

Spironolactone

Prodotto controllato

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Formula: C₂₄H₃₂O₄S

Colore e forma: Off-White

Peso molecolare: 416.57

Ref: TR-S683000

Spironolactone-d7 (Major)

Prodotto controllato

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. A representative lot was 19% d3; 47% d6; 12% d7; 7% d8; 3% d9; 3% d10 and 8% d11.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Formula: C₂₄H₂₅D₇O₄S

Colore e forma: Neat

Peso molecolare: 423.62

Ref: TR-S683002

Spironolactone

Prodotto controllato

CAS: 52-01-7

Mineralocorticoid (aldosterone) receptor antagonist; anti-hypertensive

Formula: C₂₄H₃₂O₄S

Purezza: Min. 97 Area-%

Colore e forma: White Powder

Peso molecolare: 416.57 g/mol

Ref: 3D-FS15791

Spironolactone - Bio-X ™

Prodotto controllato

CAS: 52-01-7

Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.

Formula: C₂₄H₃₂O₄S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 416.57 g/mol

Ref: 3D-BS166385

Spironolactone extrapure, 97%

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: min. 97%

Colore e forma: White, Powder

Peso molecolare: 416.60

Ref: SR-67715

17-Hydroxy-7-α-mercapto-3-oxo-17-α-pregn-4-ene-21-carboxylic acid-γ-lactone-7-acetate

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 416.5735

Ref: IN-DA00DE6I