CAS 52050-17-6

Glucosilsfingosina

Descrizione:

Glucosilsfingosina, noto anche come glucosilceramide, è un glicosfingolipide caratterizzato dalla presenza di una molecola di glucosio legata a uno scheletro di sfingosina. Svolge un ruolo cruciale nei processi cellulari, inclusi il segnalamento cellulare e la struttura della membrana. Questo composto è particolarmente significativo nel contesto di alcuni disturbi metabolici, come la malattia di Gaucher, dove la sua accumulazione può portare a vari problemi di salute. Glucosilsfingosina si trova tipicamente nelle membrane delle cellule, specialmente nel sistema nervoso e nelle cellule immunitarie, contribuendo alla formazione di zattere lipidiche che facilitano la comunicazione cellulare. La sua struttura consiste in un acido grasso a catena lunga attaccato alla sfingosina, che influenza le sue proprietà fisiche e funzioni biologiche. Il composto è solubile in solventi organici ma ha una solubilità limitata in acqua, riflettendo la sua natura anfipatica. Comprendere le caratteristiche di Glucosilsfingosina è essenziale per esplorare il suo ruolo nella salute e nella malattia, così come il suo potenziale come bersaglio terapeutico nei disturbi del metabolismo dei glicosfingolipidi.

Formula: C₂₄H₄₇NO₇

InChI: InChI=1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1

InChI key: InChIKey=HHJTWTPUPVQKNA-JIAPQYILSA-N

SMILES: O(C[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)N)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Sinonimi:

• (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• (3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl beta-D-mannopyranoside
• Glucosyl psychosine
• Glucosyl sphingosine
• Glucosyl-C₁₈-sphingosine
• Glucosylsphingosine
• Sphingosyl beta-glucoside
• beta-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, (R-(R*,S*-(E)))-
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, [R-[R*,S*-(E)]]-
• Glucosyl-C18-sphingosine
• β-D-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl
• Glucopsychosine
• β-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, [R-[R*,S*-(E)]]-
• Glcsph d18:1 (GlcbSphingolipids)
• β-D-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl

Glucosylsphingosine

CAS: 52050-17-6

Glucosylsphingosine (Lyso-Gb1) is a glycosyl ceramide that accumulates in neurodegenerative disorders and disrupts lysosomal function by activating mTORC1.

Formula: C₂₄H₄₇NO₇

Colore e forma: Solid

Peso molecolare: 461.63

Ref: TM-T78493

Glucopsycosine

CAS: 52050-17-6

Glucopsycosine

Peso molecolare: 461.63g/mol

Ref: 54-BI3460

Glucopsychosine

CAS: 52050-17-6

Formula: C24H47NO7

Purezza: >98%

Colore e forma: Solid

Peso molecolare: 461.63

Ref: 48-56-1141

Glucosylsphingosine, plant

CAS: 52050-17-6

Formula: C24H47NO7

Purezza: >98%

Colore e forma: Solid

Peso molecolare: 461.63

Ref: 48-56-1146

Glucosyl-C18-Sphingosine

CAS: 52050-17-6

Formula: C₂₄H₄₇NO₇

Peso molecolare: 461.64

Ref: 4Z-S-089022

Glucosylsphingosine

CAS: 52050-17-6

Glucosylsphingosine is a modified carbohydrate that belongs to the group of complex carbohydrates. It is a custom synthesis and has high purity with no detectable impurities. Glucosylsphingosine is an oligosaccharide, which is a polysaccharide composed of three or more monosaccharides. This compound can be methylated, glycosylated, or fluorinated in order to change its properties. Glucosylsphingosine has been synthesized from glucose and sphinganine, which are both monosaccharides. Glucose can be synthesized by the reduction of glucose-6-phosphate using glucose-6-phosphate dehydrogenase or it can be obtained from hydrolysis of starch. Sphinganine can be obtained by hydrolysis of sphingomyelin, which is a phospholipid found in cell membranes or by deacylation of N-acetyl

Formula: C₂₄H₄₇NO₇

Purezza: Min. 95%

Peso molecolare: 461.63 g/mol

Ref: 3D-MG182363

Glucosyl-C18-sphingosine

CAS: 52050-17-6

Glucosyl-C18-sphingosine is a sphingolipid that has been shown to inhibit the activity of Gaucher's enzyme, which is responsible for the synthesis of glucosylceramide. It has been demonstrated in a model system that glucosyl-C18-sphingosine inhibits mitochondrial membrane potential and decreases ATP levels, leading to cell death. The molecular pathogenesis of Gaucher disease is not well understood but it is believed to be related to defective lysosomal function. Glucosyl-C18-sphingosine may be used as a diagnostic agent for Gaucher disease and other metabolic disorders involving glucosylceramide accumulation.

Formula: C₂₄H₄₇NO₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 461.63 g/mol

Ref: 3D-MG23669

Glucosyl-C18-sphingosine-d5

Prodotto controllato

CAS: 52050-17-6

Formula: C₂₄H₄₂D₅NO₇

Colore e forma: Neat

Peso molecolare: 466.67

Ref: TR-G596841

Glucosyl-C18-sphingosine

CAS: 52050-17-6

Applications A sphingosine derivative. A sphingolipid compound found in the umbilical cord artery of women with preeclampsia.
References Romanowicz, L. et al.: Mol. Cell. Biochem. 340, 81 (2010);

Formula: C₂₄H₄₇NO₇

Colore e forma: Neat

Peso molecolare: 461.63

Ref: TR-G596840