CAS 52079-10-4

O-Desmetilnaprossene

Descrizione:

O-Desmetilnaprossene, con il numero CAS 52079-10-4, è un composto chimico che è un metabolita del farmaco antinfiammatorio non steroideo (FANS) naproxene. È caratterizzato dalla sua somiglianza strutturale con il naproxene, differendo principalmente per l'assenza di un gruppo metossile. Questo composto presenta proprietà antinfiammatorie e analgesiche, rendendolo rilevante negli studi farmacologici. O-Desmetilnaprossene si trova tipicamente in campioni biologici dopo la somministrazione di naproxene, poiché è uno dei metaboliti prodotti durante il metabolismo del farmaco nel corpo. Il composto è solubile in solventi organici e ha una solubilità relativamente bassa in acqua, il che è comune per molti FANS e i loro metaboliti. Il suo profilo farmacocinetico, che include assorbimento, distribuzione, metabolismo ed escrezione, è influenzato da fattori come il dosaggio e le variazioni metaboliche individuali. La ricerca su O-Desmetilnaprossene contribuisce a comprendere l'efficacia e i profili di sicurezza del naproxene e di FANS simili, in particolare in relazione ai loro percorsi metabolici e potenziali effetti terapeutici.

Formula: C₁₃H₁₂O₃

InChI: InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1

InChI key: InChIKey=XWJUDDGELKXYNO-QMMMGPOBSA-N

SMILES: [C@H](C(O)=O)(C)C1=CC2=C(C=C1)C=C(O)C=C2

Sinonimi:

• (+)-2-(6-Hydroxy-2-naphthyl)propionic acid
• 6-Hydroxynaproxen
• (αS)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid
• 2-Naphthaleneacetic acid, 6-hydroxy-α-methyl-, (αS)-
• 2-Naphthaleneacetic acid, 6-hydroxy-α-methyl-, (S)-

Desmethyl Naproxen ((S)-2-(6-Hydroxynaphthalen-2-yl)propanoic acid)

CAS: 52079-10-4

Carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides etc, nesoi

Formula: C₁₃H₁₂O₃

Colore e forma: Off-White Crystalline Powder

Peso molecolare: 216.07864

Ref: 45-1A10620

O-Desmethylnaproxen

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 216.2326

Ref: IN-DA00DFDJ

(S)-6-O-Desmethylnaproxen

CAS: 52079-10-4

(S)-6-O-Desmethylnaproxen

Purezza: 98%

Ref: 54-OR1039760

Naproxen EP Impurity A (O-Desmethyl Naproxen)

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 216.24

Ref: 4Z-N-233

(2S)-2-(6-Hydroxynaphthalen-2-yl)propanoic Acid (O-Demethylnaproxen)

Prodotto controllato

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Colore e forma: Neat

Peso molecolare: 216.23

Ref: 86-MM0152.06

Naproxen-O-desmethyl

Prodotto controllato

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Colore e forma: Neat

Peso molecolare: 216.23

Ref: 04-C15483600

O-Desmethylnaproxen

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Peso molecolare: 216.23

Ref: 7W-GL6106

Naproxen EP Impurity A

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Peso molecolare: 216.24

Ref: ST-EA-CP-N2001

(S)-O-Desmethyl Naproxen

Prodotto controllato

CAS: 52079-10-4

Applications A metabolite of Naproxen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),

Formula: C₁₃H₁₂O₃

Colore e forma: White

Peso molecolare: 216.23

Ref: TR-D292125

(S)-O-Desmethylnaproxen

CAS: 52079-10-4

(S)-O-Desmethylnaproxen is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the group of p-hydroxybenzoic acid derivatives. It has significant cytotoxicity against various bacterial strains and has been shown to be an effective inhibitor of mitochondrial membrane potential. This NSAID also inhibits the production of prostaglandin E2, which is involved in the inflammatory process. (S)-O-Desmethylnaproxen is metabolized by CYP450 enzymes and undergoes phase I metabolism by oxidation to form hydroxy naproxen, which is then conjugated with glucuronic acid and eliminated in urine. The substrate for this drug is naproxen, which can be found in many plants such as parsley and celery. (S)-O-Desmethylnaproxen has been shown to have a matrix effect on hl-60 cells, which may be due to its ability to inhibit protein synthesis

Formula: C₁₃H₁₂O₃

Purezza: Min. 95%

Peso molecolare: 216.23 g/mol

Ref: 3D-FD21298

(S)-O-Desmethyl Naproxen

CAS: 52079-10-4

(S)-O-Desmethyl naproxen, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen), is produced through the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.

Formula: C₁₃H₁₂O₃

Colore e forma: Solid

Peso molecolare: 216.23

Ref: TM-T84994