CAS 522-17-8

Deguelina

Descrizione:

Deguelina è un composto che si verifica naturalmente classificato come un flavonoide, specificamente un membro della famiglia dei rotenoidi. È principalmente derivato da varie specie vegetali, in particolare quelle della famiglia Fabaceae. Deguelina mostra una gamma di attività biologiche, comprese proprietà anti-infiammatorie, anti-cancerogene e anti-diabetiche, rendendolo di interesse nella ricerca farmacologica. È stato dimostrato che il composto inibisce alcuni enzimi e vie coinvolte nella proliferazione e sopravvivenza delle cellule tumorali. Chimicamente, Deguelina è caratterizzato dalla sua struttura complessa, che include più anelli e gruppi funzionali che contribuiscono alla sua reattività e attività biologica. Si trova tipicamente in forma solida a temperatura ambiente ed è solubile in solventi organici. A causa dei suoi potenziali benefici terapeutici, Deguelina ha attirato l'attenzione nei campi della chimica medicinale e della ricerca sui prodotti naturali, sebbene siano necessari ulteriori studi per comprendere appieno i suoi meccanismi d'azione e le potenziali applicazioni in contesti clinici.

Formula: C₂₃H₂₂O₆

InChI: InChI=1/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1

InChI key: InChIKey=ORDAZKGHSNRHTD-UXHICEINSA-N

SMILES: O=C1C=2C(=C3C(=CC2)OC(C)(C)C=C3)O[C@]4([C@@]1(C=5C(OC4)=CC(OC)=C(OC)C5)[H])[H]

Sinonimi:

• (-)-cis-Deguelin
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-on
• (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-pyrano[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• Deguelin
• (7aS,13aS)-9,10-Diméthoxy-3,3-diméthyl-13,13a-dihydro-3H-chroméno[3,4-b]pyrano[2,3-h]chromén-7(7aH)-one
• (7aS)-3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (7AS,13AS)-13,13A-DIHYDRO-9,10-DIMETHOXY-3,3-DIMETHYL-3H-BIS[1]BENZOPYRANO[3,4-B:6',5'-E]PYRAN-7(7AH)-ONE
• (7as-cis)-oxy-
• 3h-bis(1)benzopyrano(3,4-b:6’,5’-e)pyran-7(7ah)-one,13,13a-dihydro-9,10-dimeth
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one
• 3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (-)-DEGUELIN;(-)-CIS-DEGUELIN
• Deguelin (6CI)
• 12a-DEOXYTEPHROSIN
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-(3H)-bis[1]benzopyrano[3.4-b.6'.5'-e]pyran-7(7aH)-one

Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 394.4172

Ref: IN-DA00D7ZC

Deguelin

CAS: 522-17-8

Deguelin

Purezza: ≥95%

Peso molecolare: 394.42g/mol

Ref: 54-BUP10439

(-)-Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purezza: ≥ 98.0%

Colore e forma: White to beige powder

Peso molecolare: 394.42

Ref: 7W-GL4230

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

CAS: 522-17-8

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

Purezza: 98%

Peso molecolare: 394.42g/mol

Ref: 54-OR1026149

Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purezza: 95%~99%

Colore e forma: Powder

Peso molecolare: 394.423

Ref: BP-BP3110

Deguelin

CAS: 522-17-8

Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.

Formula: C₂₃H₂₂O₆

Purezza: 96.39% - 99.29%

Colore e forma: Solid

Peso molecolare: 394.42

Ref: TM-T6817

Deguelin

CAS: 522-17-8

Oxygen-heterocyclic compound

Formula: C₂₃H₂₂O₆

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 394.42

Ref: 5G-22641

Deguelin

Prodotto controllato

CAS: 522-17-8

Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);

Formula: C₂₃H₂₂O₆

Colore e forma: Light Yellow

Peso molecolare: 394.42

Ref: TR-D229205

(-)-Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purezza: >95.0%(HPLC)

Colore e forma: White to Yellow to Green powder to crystal

Peso molecolare: 394.42

Ref: 3B-D5646

Deguelin

CAS: 522-17-8

Deguelin is a rotenoid, which is a naturally occurring compound derived primarily from the roots of plants in the Leguminosae family, such as Mundulea sericea and Derris species. It functions as a potent inhibitor of mitochondrial complex I, interfering with cellular respiration by blocking electron transport within the mitochondrial electron transport chain. This action leads to the inhibition of ATP production, which is essential for cellular energy.

Formula: C₂₃H₂₂O₆

Purezza: Min. 95%

Peso molecolare: 394.42 g/mol

Ref: 3D-FD65404

DEGUELIN

CAS: 522-17-8

Purezza: 98%

Peso molecolare: 394.4230042

Ref: 10-F814502