CAS 52232-67-4

Teriparatide

Descrizione:

Teriparatide è una forma sintetica dell'ormone paratiroideo (PTH) utilizzata principalmente nel trattamento dell'osteoporosi. È caratterizzata dalla sua capacità di stimolare la formazione ossea, rendendola distinta da altri trattamenti per l'osteoporosi che si concentrano principalmente sull'inibizione della riassorbimento osseo. Teriparatide viene somministrato tramite iniezione sottocutanea ed è generalmente prescritto per pazienti ad alto rischio di fratture. La sostanza è composta dai primi 34 aminoacidi della PTH umana, che sono cruciali per la sua attività biologica. Il suo meccanismo d'azione implica il legame ai recettori della PTH sugli osteoblasti, promuovendo la crescita ossea e aumentando l'assorbimento di calcio nell'intestino e nei reni. Teriparatide ha una vita media relativamente breve, richiedendo somministrazione giornaliera per effetti terapeutici ottimali. Gli effetti collaterali comuni possono includere nausea, vertigini e crampi alle gambe. A causa dei suoi effetti anabolici sulle ossa, Teriparatide è spesso considerato per l'uso in donne in post-menopausa e uomini con osteoporosi che hanno una storia di fratture o significativa perdita ossea.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂・C₂H₄O<

InChI: InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)

SMILES: CCC(C)C(C(=NC(CCC(=N)O)C(=NC(CC(C)C)C(=NC(CCSC)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NCC(=NC(CCCCN)C(=NC(Cc1cnc[nH]1)C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(CO)C(=NC(CCSC)C(=NC(CCC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(C(C)C)C(=NC(CCC(=O)O)C(=NC(Cc1c[nH]c2ccccc12)C(=NC(CC(C)C)C(=NC(CCCNC(=N)N)C(=NC(CCCCN)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(CC(=O)O)C(=NC(C(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CO)N=C(C(C(C)C)N=C(C(CO)N)O)O)O)O

Sinonimi:

• Teriparatide Acetate
• Forteo
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt) hydrate
• L-Seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-phenylalanine acetate (salt) hydrate
• Parathar
• Parathar acetate
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt)

Parathyroid Hormone (1-34), human

CAS: 52232-67-4

Parathyroid Hormone (1-34), human

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Peso molecolare: 4117.7

Ref: 02-J66180

pTH (1-34) (human)

CAS: 52232-67-4

Teriparatide, which consists of the N-terminal 34 amino acid residues of parathyroid hormone, shows the same potency and pharmacological profile as the native hormone. Administration of teriparatide stimulates bone formation and increases the bone mineral density (BMD).

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purezza: 99.1%

Colore e forma: White

Peso molecolare: 4117.77

Ref: 01-4011474

pTH (1-34) (human)

CAS: 52232-67-4

Intermittent administration of teriparatide stimulates bone formation by increasing the number of osteoblasts. Agonist of the parathyroid hormone receptor PTH1.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purezza: 96.3%

Colore e forma: White

Peso molecolare: 4117.77

Ref: 01-4095855

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

CAS: 52232-67-4

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

Formula: C₁₃H₁₄ClNO

Peso molecolare: 235.7094

Ref: 41-Y0001895

TERIPARATIDE CRS

CAS: 52232-67-4

TERIPARATIDE CRS

Formula: C₁₃H₁₄ClNO

Colore e forma: Added Added

Peso molecolare: 235.7094

Ref: 41-Y0001916

Teriparatide

CAS: 52232-67-4

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Colore e forma: White Off-White Powder

Peso molecolare: 4115.13094

Ref: 45-1643962

Teriparatide acetate

CAS: 52232-67-4

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 4117.7151

Ref: IN-DA01CC00

Teriparatide Tetraacetate

CAS: 52232-67-4

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂·4C₂H₄O₂

Peso molecolare: 4117.77 4*60.05

Ref: 4Z-PT-255001

Teriparatide

CAS: 52232-67-4

Teriparatide is an agonist of PHT(IC50 of 2 nM in HEK293 cells).

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 4117.72

Ref: TM-T13128

Teriparatide acetate

CAS: 52232-67-4

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Peso molecolare: 4117.77

Ref: 7W-GX8046

pTH (1-34) (human)

CAS: 52232-67-4

pTH (1-34) (human)

Colore e forma: Solid

Ref: 54-BIBA1023

Parathyroid Hormone Fragment (1-34)- 24,d3 TFA Salt

Prodotto controllato

CAS: 52232-67-4

Stability Hygroscopic
Applications Parathyroid Hormone Fragment (1-34)-24,d3,TFA Salt is the labeled (on Leucine-d3, position 24) analogue of Parathyroid Hormone Fragment (1-34) (P192200), which is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Formula: C₁₈₁D₃H₂₈₈N₅₅O₅₁S₂·xC₂O₂HF₃

Colore e forma: Neat

Peso molecolare: 4234.8

Ref: TR-P192202

Parathyroid Hormone Fragment (1-34)

Prodotto controllato

CAS: 52232-67-4

Applications A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Colore e forma: Neat

Peso molecolare: 4117.72

Ref: TR-P192200

Teriparatide-d10

Prodotto controllato

CAS: 52232-67-4

Formula: C₁₈₁D₁₀H₂₈₁N₅₅O₅₁S₂

Colore e forma: Neat

Peso molecolare: 4127.72

Ref: TR-T512227

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.5mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is possible that in can be used in research in the treatments of some types of osteoporosis. PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purezza: Min. 95%

Peso molecolare: 4,117.7 g/mol

Ref: 3D-PTH-4068-V

TeripaRatide Acetate

CAS: 52232-67-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Peso molecolare: 4,117.8 g/mol

Ref: 3D-PP50195

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.1mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is also an effective anabolic agent used in the treatment of some forms of Osteoporosis. PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purezza: Min. 95%

Peso molecolare: 4,117.7 g/mol

Ref: 3D-PTH-4068-S