CAS 524-12-9

Wedelolattone

Descrizione:

Wedelolattone è un composto che si verifica naturalmente classificato come un derivato della cumarina, estratto principalmente da varie piante, comprese quelle del genere *Wedelia*. È caratterizzato dalla sua struttura aromatica, che include un gruppo funzionale lattone, contribuendo alle sue proprietà chimiche distintive. Il composto presenta una gamma di attività biologiche, inclusi effetti antinfiammatori, antiossidanti e potenziali effetti anticancro, rendendolo di interesse nella ricerca farmacologica. Wedelolattone è solubile in solventi organici ma ha una solubilità limitata in acqua, il che influisce sulla sua biodisponibilità e applicazione in chimica medicinale. La sua formula molecolare è C10H10O3 e ha un peso molecolare relativamente basso. La struttura del composto consente di interagire con vari bersagli biologici e gli studi in corso continuano a esplorare il suo potenziale terapeutico. Inoltre, a causa della sua origine naturale, Wedelolattone è spesso studiato per il suo ruolo nella medicina tradizionale e le sue possibili applicazioni in contesti terapeutici moderni.

Formula: C₁₆H₁₀O₇

InChI: InChI=1/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3

InChI key: InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N

SMILES: O=C1C2=C(C=3C(O1)=CC(OC)=CC3O)OC=4C2=CC(O)=C(O)C4

Sinonimi:

• 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
• 1,8,9-Trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
• 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
• 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-
• 7-Methoxy-5,11,12-Trihydroxycoumestan
• Wedelolactone
• Wedelia lactone
• Wedelolactone, ≥98%(HPLC)
• 5,11,12-Trihydroxy-7-MethoxycouMestan
• IKK Inhibitor II, Wedelolactone
• Wedelolactone CRS
• Wedelolactone, 98%, from Wedelia chinensis (Osbeck.) Merr.
• 1,8,9-trihydroxy-3-Methoxy-6H-benzofuro[3,2-c]chroMen-6-one

Wedelolactone

CAS: 524-12-9

Wedelolactone analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₁₆H₁₀O₇

Purezza: (HPLC) ≥99%

Colore e forma: Powder

Peso molecolare: 314.25

Ref: 11-0555S

WEDELOLACTONE CRS

CAS: 524-12-9

WEDELOLACTONE CRS

Formula: C₁₆H₁₀O₇

Peso molecolare: 314.2464

Ref: 41-Y0001599

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 314.2464

Ref: IN-DA00DA52

Wedelolactone

CAS: 524-12-9

Wedelolactone

Purezza: 98%

Peso molecolare: 314.25g/mol

Ref: 54-OR1022962

Wedelolactone

CAS: 524-12-9

Wedelolactone

Purezza: ≥98%

Peso molecolare: 314.25g/mol

Ref: 54-BUP07197

Wedelolactone

CAS: 524-12-9

​Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.

Formula: C₁₆H₁₀O₇

Purezza: 95%~99%

Peso molecolare: 314.249

Ref: BP-BP1451

Wedelolactone

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Purezza: >98.0%(HPLC)

Colore e forma: White to Dark green powder to crystal

Peso molecolare: 314.25

Ref: 3B-W0015

Wedelolactone

CAS: 524-12-9

Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

Formula: C₁₆H₁₀O₇

Purezza: 98.07% - 99.87%

Colore e forma: Solid

Peso molecolare: 314.25

Ref: TM-T3384

Wedelolactone

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Peso molecolare: 314.25

Ref: 7W-GL6617

Wedelolactone

CAS: 524-12-9

Lactone

Formula: C₁₆H₁₀O₇

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 314.25

Ref: 5G-89823

Wedelolactone

CAS: 524-12-9

Wedelolactone is a naturally occurring bioactive compound, classified as a coumestan, which is derived from the plant Eclipta alba, commonly referred to as false daisy. This polyphenolic compound exerts its effects through various modes of action, including inhibition of 5-lipoxygenase and modulation of NF-κB signaling pathways. The inhibition of these pathways suggests its potential role in the regulation of inflammation and cell proliferation.

Formula: C₁₆H₁₀O₇

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 314.25 g/mol

Ref: 3D-FW73945

Wedelolactone

CAS: 524-12-9

M06041 - Wedelolactone

Formula: C₁₆H₁₀O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 314.249

Ref: 10-M06041

Wedelolactone

Prodotto controllato

CAS: 524-12-9

Formula: C₁₆H₁₀O₇

Colore e forma: Neat

Peso molecolare: 314.25

Ref: TR-W980008