CAS 5297-10-9

Diidrodigossina

Descrizione:

Diidrodigossina è un glicoside cardiaco, una classe di composti noti per la loro capacità di influenzare la funzione cardiaca. È derivato dalla pianta Digitalis lanata ed è strutturalmente correlato alla digossina, comunemente usata nel trattamento di condizioni cardiache come la fibrillazione atriale e l'insufficienza cardiaca. Diidrodigossina presenta un meccanismo d'azione simile, principalmente inibendo la pompa Na+/K+ ATPasi, portando a un aumento delle concentrazioni di calcio intracellulare e a una maggiore contrattilità cardiaca. Questo composto è caratterizzato dal suo nucleo steroideo, essenziale per la sua attività biologica, e ha tipicamente un'alta affinità per i tessuti cardiaci. Diidrodigossina è meno comunemente usato rispetto alla digossina, ma potrebbe essere di interesse nella ricerca farmacologica a causa delle sue proprietà uniche e delle potenziali applicazioni terapeutiche. Come con altri glicosidi cardiaci, un attento monitoraggio del dosaggio è cruciale, poiché la finestra terapeutica è ristretta e può verificarsi tossicità, portando a gravi effetti collaterali.

Formula: C₄₁H₆₆O₁₄

InChI: InChI=1S/C41H66O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h19-31,33-38,42-45,47-48H,6-18H2,1-5H3/t19-,20-,21-,22+,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

InChI key: InChIKey=QYVJGQUFXQMOOE-STPZNEFBSA-N

SMILES: O[C@@]12[C@@](C)([C@](CC1)([C@]3(CC(=O)OC3)[H])[H])[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinonimi:

• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycardanolide
• 20,22-Dihydrodigoxin
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-12,14-Dihydroxycardanolide
• 5β-Cardanolide, 3β-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-
• Brn 1339019
• Cardanolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3-beta,5-beta,12-beta)-
• Cardanolide, 3-((O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
• Cardanolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Digoxin, 20,22-dihydro-
• Digoxin, dihydro-
• Digoxin, dihydro- (6CI)
• Dihydrodigoxin
• 5β-Cardanolide, 3β-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycardanolide

Dihydrodigoxin (Mixture of Diastereomers)

Prodotto controllato

CAS: 5297-10-9

Applications Dihydrodigoxin is a cardioinactive metabolite of Digoxin (D446575) that gets excreted in the urine after Digoxin administration in humans.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Clark, D.R., et al.: Drug Metab. Dispos., 2, 148 (1974); Reuning, R.H., et al.: Drug Metab. Dispos., 13, 51 (1985); Butler, V.P., et al.: Pharmacology, 221, 123 (1982)

Formula: C₄₁H₆₆O₁₄

Colore e forma: Neat

Peso molecolare: 782.95

Ref: TR-D452680

Dihydrodigoxin

CAS: 5297-10-9

Dihydrodigoxin is a cardiac glycoside that has been used in the treatment of congestive heart failure. It is usually administered orally and can be detected by fluorescence detector because it contains a fluorescent derivative. Dihydrodigoxin has been shown to decrease renal excretion of digoxin, which may lead to drug interactions. This drug also decreases the activity of several enzymes, including dehydroascorbic acid reductase (DHAR). DHAR catalyzes the conversion of dehydroascorbic acid to ascorbic acid, which is necessary for collagen synthesis. Dihydrodigoxin also causes preeclampsia in pregnant women and decreases blood flow to the uterus.

Formula: C₄₁H₆₆O₁₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 783 g/mol

Ref: 3D-FAA29710