CAS 53-33-8

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-triidrossi-16-metil-, (6α,11β,16α)-

Descrizione:

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-triidrossi-16-metile-, comunemente nota come Fluocinolone acetonide, è un corticosteroide sintetico con proprietà anti-infiammatorie e immunosoppressive. È caratterizzata dalla sua struttura steroidea, che include un atomo di fluoro in posizione 6 e più gruppi idrossilici che ne migliorano l'attività biologica. Questo composto è tipicamente utilizzato in formulazioni dermatologiche per trattare varie condizioni della pelle, come eczema e psoriasi, grazie alla sua capacità di ridurre l'infiammazione e sopprimere le risposte immunitarie. La presenza del sistema 1,4-diene contribuisce alla sua stabilità e potenza. La fluocinolone acetonide viene solitamente somministrata topicamente e la sua farmacocinetica può variare in base alla formulazione e al metodo di applicazione. Come con altri corticosteroidi, è importante utilizzare questo composto sotto supervisione medica per minimizzare i potenziali effetti collaterali, inclusa l'atrofia cutanea e l'assorbimento sistemico. In generale, la fluocinolone acetonide è un agente terapeutico prezioso nella gestione dei disturbi infiammatori della pelle.

Formula: C₂₂H₂₉FO₅

InChI: InChI=1/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=MKPDWECBUAZOHP-AFYJWTTESA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(C[C@@H](C)[C@@]2(C(CO)=O)O)[H]

Sinonimi:

• (6α,11β,16α)-6-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 16α-Methyl-6α-fluoroprednisolone
• 6α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 6α-Fluoro-16α-methylprednisolone
• Cortiden
• Parametasona
• Paramethason
• Paramethasone
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,17,21-trihydroxy-16-methyl-
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,17,21-trihydroxy-16α-methyl-
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
• 6-alpha-fluoro-16-alpha-methylprednisolone
• 6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
• (6alpha,11beta,16alpha)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI)
• (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
• Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI)
• 1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
• Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI)
• 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Paramethasone

CAS: 53-33-8

Parametasone is a glucocorticoid with the general properties of corticosteroids.

Formula: C₂₂H₂₉FO₅

Colore e forma: Solid

Peso molecolare: 392.46

Ref: TM-T33883L

Paramethasone

CAS: 53-33-8

Formula: C₂₂H₂₉FO₅

Peso molecolare: 392.47

Ref: 4Z-P-444004

Paramethasone

Prodotto controllato

CAS: 53-33-8

Applications Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Formula: C₂₂H₂₉FO₅

Colore e forma: White To Beige

Peso molecolare: 392.46

Ref: TR-P191840

Paramethasone

Prodotto controllato

CAS: 53-33-8

Paramethasone is a nonsteroidal anti-inflammatory drug that is used in the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and other autoimmune disorders. Its mechanism of action is not fully understood but it is believed to act by suppressing the production of pro-inflammatory cytokines. Paramethasone has been shown to be effective against cervical cancer cells and alopecia areata. This drug also has toxic effects on liver cells at high doses. The toxicity of paramethasone has been studied in experimental models and humans; it appears to be less toxic than other steroids when given orally or systemically. The most common side effect with this drug is weight gain, which may be due to an increase in fat tissue.

Formula: C₂₂H₂₉FO₅

Purezza: Min. 95%

Peso molecolare: 392.46 g/mol

Ref: 3D-FP100930

Dexamethasone Impurity 23

CAS: 53-33-8

Formula: C₂₂H₂₉FO₅

Peso molecolare: 392.47

Ref: ST-EA-CP-D17049