CAS 53-86-1

Indometacina

Descrizione:

Indometacina è un farmaco antinfiammatorio non steroideo (FANS) utilizzato principalmente per alleviare il dolore, il gonfiore e l'infiammazione associati a varie condizioni, come l'artrite e la gotta. È classificato come un derivato dell'acido indolacetico e presenta potenti proprietà antinfiammatorie e analgesiche. La formula chimica di Indometacina è C19H16ClN e ha un peso molecolare di circa 357,79 g/mol. Indometacina agisce inibendo gli enzimi cicloossigenasi (COX), che svolgono un ruolo cruciale nella sintesi delle prostaglandine, mediatori dell'infiammazione e del dolore. La sostanza viene tipicamente somministrata per via orale, ma può anche essere somministrata per via rettale o endovenosa. Indometacina è noto per i suoi potenziali effetti collaterali, che possono includere problemi gastrointestinali, rischi cardiovascolari e compromissione renale, richiedendo un attento monitoraggio durante l'uso. La sua solubilità è moderata in acqua, ma è più solubile nei solventi organici, il che influisce sulla sua formulazione nelle preparazioni farmaceutiche. In generale, Indometacina rimane un importante agente terapeutico nella gestione delle condizioni infiammatorie.

Formula: C₁₉H₁₆ClNO₄

InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key: InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Sinonimi:

• 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• Aconip
• Amuno
• Argun
• Artracin
• Artrinovo
• Artrivia
• Bonidin
• Bonidon Gel
• Catlep
• Chibro-Amuno
• Chrono-Indicid
• Chrono-Indocid 75
• Confortid
• Dolcidium
• Dolcidium PL
• Dolovin
• Durametacin
• Elmetacin
• Endol
• Flam
• Globa
• Idomethine
• Imbrilon
• Inacid
• Indacin
• Indo-Phlogont
• Indo-Rectolmin
• Indo-Tablinen
• IndoRich
• Indocid
• Indocid (pharmaceutical)
• Indocin
• Indocine
• Indocollyre
• Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
• Indomecol
• Indomed
• Indomee
• Indometacin
• Indometacina
• Indometacine
• Indomethacin Crystalline
• Indomethacin Methanol Solution
• Indomethacin Powder
• Indomethacin Usp
• Indomethacine
• Indomethine
• Indomod
• Indonol
• Indoptic
• Indoptol
• Indorektal
• Indoxen
• Indren
• Inflazon
• Infrocin
• Innamit
• Inteban
• Inteban SP
• Lausit
• Metacen
• Metartril
• Methazine
• Metindol
• Mezolin
• Microcid
• Mikametan
• Mobilan
• N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• Nsc 77541
• Reumacide
• Rheumacin LA
• Sadoreum
• Tannex
• Vital Vitacid
• Vonum
• [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate

Indomethacin

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow to Light orange powder to crystal

Peso molecolare: 357.79

Ref: 3B-I0655

Indomethacin, 98%

CAS: 53-86-1

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p

Formula: C₁₉H₁₆ClNO₄

Purezza: 98%

Colore e forma: White to pale cream, Powder

Peso molecolare: 357.79

Ref: 02-A19910

Indomethacin, 99+%

CAS: 53-86-1

Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.

Formula: C₁₉H₁₆ClNO₄

Purezza: 99+%

Peso molecolare: 357.8

Ref: 02-J63255

Indometacin

CAS: 53-86-1

Colore e forma: Neat

Ref: 61-FOR0584.00

Indometacin 1.0 mg/ml in Acetonitrile

CAS: 53-86-1

Colore e forma: Single Solution

Ref: 61-AMP0584.00-11

INDOMETACIN IMPURITY MIXTURE CRS

CAS: 53-86-1

INDOMETACIN IMPURITY MIXTURE CRS

Formula: C₁₇H₁₉N₃

Peso molecolare: 265.3529

Ref: 41-Y0001640

INDOMETACIN CRS

CAS: 53-86-1

INDOMETACIN CRS

Formula: C₁₇H₁₉N₃

Colore e forma: Crystalline Powder. White. Yellow. Powder.

Peso molecolare: 265.3529

Ref: 41-I0200000

Indomethacin

CAS: 53-86-1

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Formula: C₁₉H₁₆ClNO₄

Colore e forma: White Yellow Powder

Peso molecolare: 357.79

Ref: 45-1341001

Indomethacin

CAS: 53-86-1

Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.

Formula: C₁₉H₁₆ClNO₄

Purezza: 99.27% - 99.76%

Colore e forma: Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)

Peso molecolare: 357.79

Ref: TM-T0458

Indomethacin

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Colore e forma: White To Off-White Solid

Peso molecolare: 357.79

Ref: 4Z-I-121

Indomethacin

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White to off-white or pale pink powder

Peso molecolare: 357.80

Ref: 7W-GA3090

Indomethacin

CAS: 53-86-1

Indomethacin

Purezza: ≥98%

Peso molecolare: 357.79g/mol

Ref: 54-BUP19211

Indomethacin, BP grade

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Purezza: (Titration) 98.5 - 100.5 % (dried basis)

Colore e forma: White to yellow powder or crystals

Peso molecolare: 357.80

Ref: 7W-GP6163

Indomethacin (Indometacin) EP Impurity D

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Colore e forma: White To Off-White Solid

Peso molecolare: 357.79

Ref: 4Z-I-1212

Indometacin

Prodotto controllato

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Colore e forma: Neat

Peso molecolare: 357.79

Ref: 86-MM0584.00

Indomethacine

Prodotto controllato

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Colore e forma: Neat

Peso molecolare: 357.79

Ref: 04-C14325000

Indometacin RS

CAS: 53-86-1

Colore e forma: White To Pale Reddish Yellow Solid Crystals To Powder

Ref: 2K-1019000021

Indomethacin

Prodotto controllato

CAS: 53-86-1

Impurity Acemetacin EP Impurity B
Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)

Formula: C₁₉H₁₆ClNO₄

Colore e forma: Beige

Peso molecolare: 357.79

Ref: TR-I641000

Acemetacin EP Impurity B

CAS: 53-86-1

Formula: C₁₉H₁₆ClNO₄

Peso molecolare: 357.8

Ref: ST-EA-CP-A42002

Indomethacin

CAS: 53-86-1

Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.

Formula: C₁₉H₁₆ClNO₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 357.79 g/mol

Ref: 3D-FI24585