CAS 53-86-1
:Indometacina
Descrizione:
Indometacina è un farmaco antinfiammatorio non steroideo (FANS) utilizzato principalmente per alleviare il dolore, il gonfiore e l'infiammazione associati a varie condizioni, come l'artrite e la gotta. È classificato come un derivato dell'acido indolacetico e presenta potenti proprietà antinfiammatorie e analgesiche. La formula chimica di Indometacina è C19H16ClN e ha un peso molecolare di circa 357,79 g/mol. Indometacina agisce inibendo gli enzimi cicloossigenasi (COX), che svolgono un ruolo cruciale nella sintesi delle prostaglandine, mediatori dell'infiammazione e del dolore. La sostanza viene tipicamente somministrata per via orale, ma può anche essere somministrata per via rettale o endovenosa. Indometacina è noto per i suoi potenziali effetti collaterali, che possono includere problemi gastrointestinali, rischi cardiovascolari e compromissione renale, richiedendo un attento monitoraggio durante l'uso. La sua solubilità è moderata in acqua, ma è più solubile nei solventi organici, il che influisce sulla sua formulazione nelle preparazioni farmaceutiche. In generale, Indometacina rimane un importante agente terapeutico nella gestione delle condizioni infiammatorie.
Formula:C19H16ClNO4
InChI:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Sinonimi:- 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
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- Nsc 77541
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- [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate
- Vedi altri sinonimi
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Indomethacin
CAS:Formula:C19H16ClNO4Purezza:>98.0%(T)(HPLC)Colore e forma:White to Light yellow to Light orange powder to crystalPeso molecolare:357.79Indomethacin, 98%
CAS:<p>It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p</p>Formula:C19H16ClNO4Purezza:98%Colore e forma:White to pale cream, PowderPeso molecolare:357.79Indomethacin, 99+%
CAS:<p>Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.</p>Formula:C19H16ClNO4Purezza:99+%Peso molecolare:357.8INDOMETACIN IMPURITY MIXTURE CRS
CAS:INDOMETACIN IMPURITY MIXTURE CRSFormula:C17H19N3Peso molecolare:265.3529INDOMETACIN CRS
CAS:INDOMETACIN CRSFormula:C17H19N3Colore e forma:Crystalline Powder. White. Yellow. Powder.Peso molecolare:265.3529Indomethacin
CAS:Analgesics, antipyretics and non-hormonal anti-inflammatory agentsFormula:C19H16ClNO4Colore e forma:White Yellow PowderPeso molecolare:357.79Indomethacin
CAS:Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.Formula:C19H16ClNO4Purezza:99.27% - 99.76%Colore e forma:Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)Peso molecolare:357.79Indomethacin
CAS:Formula:C19H16ClNO4Purezza:≥ 98.0% (dried basis)Colore e forma:White to off-white or pale pink powderPeso molecolare:357.80Indomethacin, BP grade
CAS:Formula:C19H16ClNO4Purezza:(Titration) 98.5 - 100.5 % (dried basis)Colore e forma:White to yellow powder or crystalsPeso molecolare:357.80Indomethacin (Indometacin) EP Impurity D
CAS:Formula:C19H16ClNO4Colore e forma:White To Off-White SolidPeso molecolare:357.79Indomethacin
CAS:Prodotto controllato<p>Impurity Acemetacin EP Impurity B<br>Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C19H16ClNO4Colore e forma:BeigePeso molecolare:357.79Indomethacin
CAS:<p>Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.</p>Formula:C19H16ClNO4Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:357.79 g/molIndomethacin - Bio-X ™
CAS:<p>Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C19H16ClNO4Purezza:(%) Min. 95%Colore e forma:PowderPeso molecolare:357.79 g/mol
