CAS 53164-05-9

Acemetacina

Descrizione:

Acemetacina è un farmaco antinfiammatorio non steroideo (FANS) che viene utilizzato principalmente per le sue proprietà analgesiche e antinfiammatorie. È un derivato dell'indometacina e si caratterizza per la sua capacità di inibire le enzimi cicloossigenasi, che svolgono un ruolo cruciale nella sintesi delle prostaglandine coinvolte nell'infiammazione e nella segnalazione del dolore. Acemetacina viene tipicamente somministrato per via orale ed è noto per la sua tolleranza gastrointestinale relativamente favorevole rispetto ad altri FANS. La sostanza presenta una solubilità moderata ad alta nei solventi organici, mentre la sua solubilità in acqua è limitata. La sua farmacocinetica comporta un rapido assorbimento e metabolismo, portando alla formazione del suo metabolita attivo, indometacina. Acemetacina è spesso prescritto per condizioni come artrite, disturbi muscoloscheletrici e dolore post-operatorio. Come altri FANS, può comportare rischi di effetti collaterali cardiovascolari e gastrointestinali, richiedendo una attenta considerazione della storia clinica del paziente e dei farmaci concomitanti. In generale, Acemetacina rappresenta un'opzione efficace nella gestione del dolore e dell'infiammazione.

Formula: C₂₁H₁₈ClNO₆

InChI: InChI=1/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)

InChI key: InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(OCC(O)=O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Sinonimi:

• ((1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure
• (1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure [German]
• ({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ester with glycolic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
• 2-(2-(1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
• 2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
• 2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid
• Acemet
• Acemetacin [INN:BAN:JAN]
• Acemetacina
• Acemetacina [INN-Spanish]
• Acemetacine
• Acemetacine [INN-French]
• Acemetacinum
• Acemetacinum [INN-Latin]
• Acemethacin
• Acemethazine
• Acemix
• Aximeixin
• Bay f 4975
• Brn 0501672
• Emflex
• K 708
• Rantudil
• Rheumibis
• Rheutrop
• Solart
• Tv 1322
• Tvx 1322
• Tvx 3322
• Unii-5V141Xk28X
• Acemetacin
• 5-22-05-00241 (Beilstein Handbook Reference)
• Acemetacin
• 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)aceticacid
• [1-(4-CHLORO-BENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-ACETIC ACID CARBOXYMETHYL ESTER
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacidcarboxymethyl
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacicarboxymethyl
• AURORA KA-6229
• ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)aceticacid
• 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic aci carboxymethyl ((1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid (1-(p-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetic acid carboxymethyl 2-(2-(1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid acemetacin acemetacinum acemix

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Purezza: >98.0%(GC)(T)

Colore e forma: Light yellow to Yellow to Green powder to crystal

Peso molecolare: 415.83

Ref: 3B-A2452

Acemetacin

CAS: 53164-05-9

A potent inhibitor of COX-2 found to have anti-tumor activity in the colon

Formula: C₂₁H₁₈ClNO₆

Peso molecolare: 415.83

Ref: 02-J63583

ACEMETACIN CRS

CAS: 53164-05-9

ACEMETACIN CRS

Formula: C₂₁H₁₈ClNO₆

Colore e forma: Yellow. Powder.

Peso molecolare: 415.8237

Ref: 41-Y0000810

ACEMETACIN IMPURITY MIXTURE CRS

CAS: 53164-05-9

ACEMETACIN IMPURITY MIXTURE CRS

Formula: C₂₁H₁₈ClNO₆

Peso molecolare: 415.8237

Ref: 41-Y0000842

Acemetacin

CAS: 53164-05-9

Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin.

Formula: C₂₁H₁₈ClNO₆

Purezza: 99.26%

Colore e forma: Light Yellow Solid

Peso molecolare: 415.82

Ref: TM-T1467

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Peso molecolare: 415.83

Ref: 7W-GP9625

Acemetacin, 10mM (in DMSO)

CAS: 53164-05-9

Acemetacin, 10mM (in DMSO)

Purezza: ≥98%

Peso molecolare: 415.82g/mol

Ref: 54-BUP19931

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Colore e forma: Pale Yellow Solid

Peso molecolare: 415.83

Ref: 4Z-A-442

Acemetacin

CAS: 53164-05-9

Acemetacin

Purezza: ≥98%

Peso molecolare: 415.82g/mol

Ref: 54-BUP17595

Acemetacin

Prodotto controllato

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Colore e forma: Neat

Peso molecolare: 415.82

Ref: 86-MM1728.00

Acemetacin

CAS: 53164-05-9

Formula: C₂₁H₁₈ClNO₆

Colore e forma: Yellow

Peso molecolare: 415.82

Ref: 04-C10007000

Acemetacin-d4

CAS: 53164-05-9

Formula: C₂₁H₁₄ClNO₆D₄

Peso molecolare: 419.86

Ref: 4Z-A-443

Acemetacin

Prodotto controllato

CAS: 53164-05-9

Applications Acemetacin is a non-steroidal anti-inflammatory agent and used to treat rheumatic disease and other musculoskeletal disorders (1,2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Jacobi, H. and Dell, H. D.: Arzneimittelforschung 30, 1398 (1980) (2) Moore, R. A., et al.: Cochrane Database Syst Rev. 8,CD007589 (2009)

Formula: C₂₁H₁₈ClNO₆

Colore e forma: Yellow

Peso molecolare: 415.82

Ref: TR-A130700

Acemetacin

CAS: 53164-05-9

Non-steroidal anti-inflammatory drug

Formula: C₂₁H₁₈ClNO₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 415.82 g/mol

Ref: 3D-FA16912

Acemetacin

CAS: 53164-05-9

Colore e forma: Neat

Ref: 61-FOR1728.00