CAS 53949-53-4

Acido 2-[4'-(1-idrossi-2-metilpropil)fenil]propionico

Descrizione:

Acido 2-[4'-(1-idrossi-2-metilpropil)fenil]propionico, comunemente noto come un farmaco antinfiammatorio non steroideo (FANS), presenta diverse caratteristiche notevoli. È una polvere cristallina bianca a bianco sporco che è solubile in solventi organici ma ha una solubilità limitata in acqua. Il composto presenta un gruppo acido propionico, che contribuisce alle sue proprietà antinfiammatorie e analgesiche. La sua struttura include un anello fenilico sostituito con un gruppo idrossile e una catena alchilica ramificata, che influisce sul suo profilo farmacocinetico, inclusi assorbimento e metabolismo. Il composto agisce inibendo le enzimi cicloossigenasi, riducendo così la sintesi delle prostaglandine coinvolte nell'infiammazione e nella segnalazione del dolore. Inoltre, può mostrare gradi variabili di selettività per le isoforme COX-1 e COX-2, influenzando i suoi effetti terapeutici e il profilo degli effetti collaterali. Come molti FANS, gli effetti collaterali potenziali possono includere disagio gastrointestinale e rischi cardiovascolari, richiedendo una considerazione attenta nell'uso clinico. Nel complesso, questo composto rappresenta una classe significativa di farmaci utilizzati per il sollievo dal dolore e la gestione dell'infiammazione.

Formula: C₁₃H₁₈O₃

InChI: InChI=1S/C13H18O3/c1-8(2)12(14)11-6-4-10(5-7-11)9(3)13(15)16/h4-9,12,14H,1-3H3,(H,15,16)

InChI key: InChIKey=RMOQYHYFRKTDRI-UHFFFAOYSA-N

SMILES: C(C(O)=O)(C)C1=CC=C(C(C(C)C)O)C=C1

Sinonimi:

• 2-[4′-(1-Hydroxy-2-methylpropyl)phenyl]propionic acid
• Benzeneacetic acid, 4-(1-hydroxy-2-methylpropyl)-α-methyl-
• 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid
• 4-(1-Hydroxy-2-methylpropyl)-α-methylbenzeneacetic acid
• 1-Hydroxyibuprofen
• Imp. L (EP): 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic Acid(1-Hydroxyibuprofen)
• Ibuprofen EP Impurity L
• Ibuprofen EP Impurity
• 2-[4-(1-Hydroxy-2-methylpropyl)phen
• Ibuprofen EP Impurity L：Ibuprofen Impurity L
• Ibuprofen Impurity 12
• 1-Hydroxy Ibuprofen (Ibuprofen Impurity L)
• Ibuprofen impurity 6/Ibuprofen EP Impurity L/1-Hydroxy Ibuprofen
• Ibuprofen IMpurity-L(EP/BP)
• 1-Hydroxy Ibuprofen (Ibuprofen Impurity L)(Mixture of Diastereomers)
• Benzeneacetic acid, 4-(1-hydroxy-2-methylpropyl)--alpha--methyl- (9CI)
• 1-Hydroxy-ibuprofen - Mixture of diastereoisomers

Hydroxy Ibuprofen (2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid)

CAS: 53949-53-4

Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoi

Formula: C₁₃H₁₈O₃

Colore e forma: White Solid

Peso molecolare: 222.28

Ref: 45-1A13310

2-(4-(1-Hydroxy-2-methylpropyl)phenyl)propanoic acid

CAS: 53949-53-4

2-(4-(1-Hydroxy-2-methylpropyl)phenyl)propanoic acid

Purezza: 99%

Peso molecolare: 222.28g/mol

Ref: 54-OR1065756

1-Hydroxy-ibuprofen

CAS: 53949-53-4

1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.

Formula: C₁₃H₁₈O₃

Colore e forma: Solid

Peso molecolare: 222.2802

Ref: TM-T38215

Ibuprofen EP Impurity L

CAS: 53949-53-4

Formula: C₁₃H₁₈O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 222.28

Ref: 4Z-I-0437

2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic Acid (1-Hydroxyibuprofen)

Prodotto controllato

CAS: 53949-53-4

Formula: C₁₃H₁₈O₃

Colore e forma: Neat

Peso molecolare: 222.28

Ref: 86-MM0002.24

Ibuprofen-1-hydroxy

CAS: 53949-53-4

Formula: C₁₃H₁₈O₃

Colore e forma: Neat

Peso molecolare: 222.28

Ref: 04-C14278150

1-Hydroxy Ibuprofen (Ibuprofen Impurity L) (Mixture of Diastereomers)

CAS: 53949-53-4

Impurity Ibuprofen EP Impurity L
Applications 1-Hydroxy Ibuprofen (Ibuprofen EP Impurity L) is a degradation product of Ibuprofen.
References Forrest, J., et al.: Clin. Pharmacokinet., 7(2), 93 (1982), Shockcor, J., et al.: Xenobiotica, 26, 189 (1996), Nicholls, A., et al.: Chem. Res. Toxicol., 14, 975 (2001), Holmes, E., et al.: Toxicol. Sci., 87, 1 (2005),

Formula: C₁₃H₁₈O₃

Colore e forma: Off-White

Peso molecolare: 222.28

Ref: TR-H942858

Ibuprofen EP Impurity L

CAS: 53949-53-4

Formula: C₁₃H₁₈O₃

Peso molecolare: 222.28

Ref: ST-EA-CP-I2012

1-Hydroxy-ibuprofen - Mixture of diastereoisomers

CAS: 53949-53-4

Ibuprofen is a nonsteroidal anti-inflammatory drug that is used to treat arthritis, rheumatoid arthritis, menstrual cramps and pain. Ibuprofen is a racemic mixture of two enantiomers, ibuprofen and S (+) -ibuprofen. The dextran sulfate method is an analytical method used to determine the concentration of ibuprofen in biological fluids such as human serum or urine. This test can be done by first treating the sample with trifluoroacetic acid (TFA) to convert ibuprofen to its glucuronide conjugate. The glucuronide conjugates are then deproteinized with hydrochloric acid, which converts them into their corresponding carboxylated derivatives. This conversion allows for the separation of ibuprofen from interfering substances using preparative hplc and quantification using mass spectrometry. Toxicity studies have been conducted on bacteria strains and inflammatory bowel

Formula: C₁₃H₁₈O₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 222.28 g/mol

Ref: 3D-IH31798