CAS 54-05-7

Clorochina

Descrizione:

Clorochina è un composto sintetico conosciuto principalmente per il suo uso come farmaco antimalarico. Appartiene alla classe delle 4-aminochinoline ed è caratterizzato dalla sua capacità di interferire con la crescita dei parassiti nei globuli rossi. La formula chimica di Clorochina è C18H26ClN3 e ha un peso molecolare di circa 319,87 g/mol. Clorochina è tipicamente presentato come una polvere cristallina bianca o bianco sporco, solubile in acqua e con un sapore amaro. Il suo meccanismo d'azione implica l'inibizione della polimerizzazione dell'eme all'interno del parassita della malaria, portando a un'accumulo tossico di eme. Oltre alle sue proprietà antimalariche, Clorochina è stato anche studiato per potenziali effetti antivirali e come agente anti-infiammatorio in condizioni come l'artrite reumatoide e il lupus. Tuttavia, il suo uso è stato associato a vari effetti collaterali, tra cui disturbi gastrointestinali e tossicità retinica con uso a lungo termine. A causa dell'emergere di ceppi di malaria resistenti ai farmaci, l'efficacia di Clorochina è diminuita in alcune regioni, spingendo all'esplorazione di trattamenti alternativi.

Formula: C₁₈H₂₆ClN₃

InChI: InChI=1/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)/t14-/m0/s1

InChI key: InChIKey=WHTVZRBIWZFKQO-UHFFFAOYSA-N

SMILES: N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinonimi:

• (4S)-N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-
• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-
• 4-(7-Chloro-4-Quinolylamino)Pentyldiethylamine
• 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
• Aralen
• Artrichin
• Bipiquin
• Capquin
• Chloraquine
• Chloro Quine Phosphate
• Chlorochin
• Chlorolex
• Chloroquin
• Cloquin
• Cloroquina
• E-Vivax
• Maliago
• N⁴-(7-Chloro-4-quinolinyl)-N¹,N¹-diethyl-1,4-pentanediamine
• Nivaquinp
• Nsc 187208
• Premoquine
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-
• Reumachlor
• Ronaquine
• Rp 3377
• ST 121 (pharmaceutical)
• St 121
• N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
• Quinagamin
• Chlorquin
• Chloroquina
• 3377 RP
• Cocartrit
• Avlochlor
• Arthrochin
• Imagon
• Sopaquin
• Chingamin
• 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline
• WIN 244
• Bemaphate
• Quinachlor
• Nivaquine B
• -[7-Chloro-4-quinolinyl]-N',N'-diethyl-1,4-pentanediamine
• Lapaquin
• SN 6718
• Cidanchin
• Quinoscan
• 7-CHLORO-4-(4-DIMETHYLAMINO-1-METHYLBUTYLAMINO)QUINOLINE
• Delagil
• Diphenylhydramine
• Nivaquine
• Bemasulph
• Elestol
• w7618
• 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-quinolin
• n(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-4-pentanediamine
• Resoquine
• Tanakan
• nivaquineb
• Arechin
• SN 7618
• Benaquin
• W 7618
• Mesylith
• Silbesan
• Sanoquin
• Quinercyl
• N(sup4)-(7-chloro-4-quinolinyl)-N(sup1),N(sup1)-diethyl-1,4-pentanediamine
• Avloclor
• 4-(4-Diethylamino-1-methylbutylamino)-7-chloroquinoline
• Clorochina
• CHLOROQUINE
• 3377 RP opalate
• 4-(4-Diethylamino-1-methylbntyla-mino)-7-chloroquinoline
• Nivaquine [as sulfate]
• N
• Reumaquin
• Tresochin
• Malaquin
• 4
• Neochin
• Malarex
• Dichinalex
• Chloroquine (base and/or unspecified salts)
• Resochin
• Quingamine
• (7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline
• win244
• Cloroquine
• Nivachine
• Amokin
• Resochen
• rp3377
• Quinagamine
• Chemochin
• Gontochin
• 1,4-pentanediamine,n(sup4)-(7-chloro-4-quinolinyl)-n(sup1),n(sup1)-diethy
• Solprina
• sn7618
• Siragan
• Trochin
• Resoquina
• Malaren
• Chloroquinium
• N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diaMine
• Bemaco
• Heliopar
• Klorokin
• Roquine
• Iroquine
• Pfizerquine
• Chlorochine

Chloroquine

CAS: 54-05-7

Formula: C₁₈H₂₆ClN₃

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 319.8721

Ref: IN-DA00DDVD

N4-(7-Chloroquinolin-4-Yl)-N1,N1-Diethylpentane-1,4-Diamine

CAS: 54-05-7

N4-(7-Chloroquinolin-4-Yl)-N1,N1-Diethylpentane-1,4-Diamine

Purezza: 97%

Peso molecolare: 319.87g/mol

Ref: 54-OR1014213

Chloroquine

CAS: 54-05-7

Chloroquine

Purezza: ≥95%

Peso molecolare: 319.87g/mol

Ref: 54-BUP17107

Chloroquine

CAS: 54-05-7

Formula: C₁₈H₂₆ClN₃

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to lump

Peso molecolare: 319.88

Ref: 3B-C3730

Chloroquine

CAS: 54-05-7

Chloroquine: antimalarial, anti-inflammatory, autophagy/TLRs inhibitor, treats arthritis, effective against COVID-19 in vitro. EC50: 1.13 μM.

Formula: C₁₈H₂₆ClN₃

Purezza: 99.5% - 99.98%

Colore e forma: White To Slightly Yellow Crystalline Powder Solid

Peso molecolare: 319.87

Ref: TM-T8689

Chloroquine

CAS: 54-05-7

Applications Chloroquine used in the treatment of malaria and MDR-strains. It is a COVID19-related research product.
References Laufer, M. et al.: PLoS One., 7, e42284 (2012); Hangartner, S. et al.: Drug Test. ANal., 5, 777 (2013)

Formula: C₁₈H₂₆ClN₃

Colore e forma: White To Light Brown

Peso molecolare: 319.87

Ref: TR-C380318

Chloroquine

CAS: 54-05-7

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine is are an schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and the glycoprofile on the S-glycoprotein.

Formula: C₁₈H₂₆ClN₃

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 319.87 g/mol

Ref: 3D-FC150960

N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine

CAS: 54-05-7

Formula: C₁₈H₂₆ClN₃

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 319.88

Ref: 10-F242503