CAS 54-42-2

5-Iodo-2'-desossiuridina

Descrizione:

5-Iodo-2'-desossiuridina (IDU) è un analogo nucleosidico della timidina, caratterizzato dalla presenza di un atomo di iodio nella posizione 5 dell'anello pirimidinico. È utilizzato principalmente nella ricerca antivirale e come potenziale agente terapeutico nel trattamento del cancro grazie alla sua capacità di interferire con la sintesi del DNA. L'IDU è una polvere cristallina bianca a bianco sporco, solubile in acqua e presenta un profilo di stabilità moderato in condizioni fisiologiche. La sua formula molecolare è C₁₃H₁₂I N₃O₅ e ha un peso molecolare che riflette la sua struttura complessa. Il composto è noto per inibire la replicazione virale, in particolare nel contesto del virus herpes simplex, ed è anche studiato per i suoi effetti sui processi cellulari. L'IDU può essere incorporato nel DNA durante la replicazione, portando a mutazioni e, infine, alla morte cellulare, che è un meccanismo sfruttato nella terapia del cancro. Sono necessarie precauzioni di sicurezza e gestione a causa dei suoi potenziali effetti biologici, e deve essere utilizzato in ambienti di laboratorio controllati.

Formula: C₉H₁₁IN₂O₅

InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI key: InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(I)C(=O)N1

Sinonimi:

• 1-(2-Dehydroxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione
• 2'-Desoxy-5-iodouridine
• 2-Deoxy-5-iodouridine
• 5-Iodo-2'-Deoxy-D-Uridine
• 5-Iodo-2'-desoxyuridine
• 5-Iodo-deoxyuridine
• 5-Iododeoxyuridine
• 5-Iodouracil deoxyriboside
• 5Iudr
• Allergan 211
• Dendrid
• Emanil
• Herpe-Gel
• Herpesil
• Herpidu
• Herplex
• IDU
• Idexur
• Idoxene
• Idoxuridin
• Idoxuridina
• Idoxuridine
• Idu Oculos
• Iducher
• Idulea
• Idur
• Iduridin
• Iododeoxyuridine
• Iudr
• Joddeoxiuridin
• Kerecid
• Nsc 39661
• Ophthalmadine
• Skf 14287
• Stoxil
• Stoxip
• Synmiol
• Uridine, 2'-deoxy-5-iodo-
• Virudox

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purezza: >99.0%(T)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 354.10

Ref: 3B-I0258

(+)-5-Iodo-2'-deoxyuridine, 98%

CAS: 54-42-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₉H₁₁IN₂O₅

Purezza: 98%

Colore e forma: White to pale cream, Crystals or powder or crystalline powder

Peso molecolare: 354.10

Ref: 02-A11542

IDOXURIDINE CRS

CAS: 54-42-2

IDOXURIDINE CRS

Formula: C₉H₁₁IN₂O₅

Colore e forma: Powder

Peso molecolare: 354.0985

Ref: 41-I0050000

Idoxuridine

CAS: 54-42-2

Idoxuridine

Formula: C₉H₁₁IN₂O₅

Purezza: 99.9%

Colore e forma: White

Peso molecolare: 353.97127

Ref: 47-202

Idoxuridine

CAS: 54-42-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₁IN₂O₅

Colore e forma: White Crystalline Powder

Peso molecolare: 353.97127

Ref: 45-1336001

Idoxuridine

CAS: 54-42-2

Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.

Formula: C₉H₁₁IN₂O₅

Purezza: 99.45% - 99.62%

Colore e forma: Crystals From Water Triclinic Solid

Peso molecolare: 354.1

Ref: TM-T0863

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 354.0985

Ref: IN-DA003AAB

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

5-Iodo-2'-deoxyuridine

Purezza: 99%

Peso molecolare: 354.10g/mol

Ref: 54-OR72935

Idoxuridine

CAS: 54-42-2

Idoxuridine

Purezza: ≥98%

Peso molecolare: 354.1g/mol

Ref: 54-BUP18492

5-Iodo-2''-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purezza: ≥ 98.5%

Colore e forma: White to off-white crystalline powder

Peso molecolare: 354.10

Ref: 7W-GP1769

Idoxuridine

Prodotto controllato

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Colore e forma: Neat

Peso molecolare: 354.10

Ref: 86-MM0791.00

Idoxuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Colore e forma: Neat

Peso molecolare: 354.10

Ref: 04-C14278800

Idoxuridine RS

CAS: 54-42-2

Colore e forma: Colorless Or White

Ref: 2K-1015000021

Idoxuridine

Prodotto controllato

CAS: 54-42-2

Applications Idoxuridine is an antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
References Chang, C., et al.: J. Biol. Chem., 267, 22414 (1992), Pressacco, J., et al.: Cancer Res., 54, 3772 (1994),

Formula: C₉H₁₁IN₂O₅

Colore e forma: Neat

Peso molecolare: 354.10

Ref: TR-I205750

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a novel nucleoside that has antiviral and anticancer properties. It is an analog of uridine, which is the building block for RNA. 2'-Deoxy-5-iodouridine can be phosphorylated to form diphosphate, monophosphate, and triphosphate forms. It can also be modified to form phosphoramidites or deoxyribonucleosides. This drug has been shown to have anticancer effects on various types of cancer cells and has been used in the treatment of leukemia and other cancers.

Formula: C₉H₁₁IN₂O₅

Purezza: Min. 99.0 Area-%

Peso molecolare: 354.1 g/mol

Ref: 3D-Q-201230

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.

Formula: C₉H₁₁IN₂O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 354.1 g/mol

Ref: 3D-ND05147

2'-Deoxy-5-iodouridine - EP

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM.
2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.

Formula: C₉H₁₁IN₂O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 354.1 g/mol

Ref: 3D-ND172114

5-Iodo-2′-deoxyuridine

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purezza: 95%

Colore e forma: Solid, White powder

Peso molecolare: 354.1

Ref: 10-F092965

5-Iodo-2-Deoxyuridine extrapure, 98%

CAS: 54-42-2

Formula: C₉H₁₁IN₂O₅

Purezza: min. 98%

Colore e forma: White to off-white, Crystalline powder

Peso molecolare: 354.10

Ref: SR-83441

Idoxuridine

CAS: 54-42-2

Colore e forma: Neat

Ref: 61-FOR0791.00