CAS 54-62-6

Aminopterina

Descrizione:

Aminopterina è un antagonista del folato e un membro della classe di composti Aminopterina, noto principalmente per il suo ruolo come antimetabolita nella terapia del cancro e come agente immunosoppressore. È una polvere cristallina bianca a gialla pallida che è solubile in acqua e presenta un profilo di solubilità dipendente dal pH. La struttura chimica di Aminopterina presenta un anello di pteridina, essenziale per la sua attività biologica, e inibisce l'enzima diidrofolato reduttasi, interferendo così con la sintesi del DNA e la proliferazione cellulare. Questo meccanismo lo rende efficace nel trattamento di alcuni tipi di leucemia e altre malignità. Inoltre, Aminopterina è stato utilizzato in contesti di ricerca per studiare il metabolismo del folato e le sue implicazioni in vari processi biologici. Tuttavia, il suo uso è associato a effetti collaterali significativi, tra cui soppressione del midollo osseo e disturbi gastrointestinali, richiedendo un attento monitoraggio durante il trattamento. A causa di queste caratteristiche, Aminopterina è un composto critico sia nelle applicazioni cliniche che nella ricerca nel campo della chimica medicinale.

Formula: C₁₉H₂₀N₈O₅

InChI: InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1

InChI key: InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N

SMILES: NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Sinonimi:

• (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-4-Deoxypteroylglutamate
• 4-Amino-Folicaci
• 4-Amino-Pga[Qr]
• 4-Aminofolic Acid
• 4-Aminofolicacid[Qr]
• 4-Aminopteroylglutamic acid
• 4-Aminopteroylglutamicacid[Qr]
• 4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-N-(P-(((L-Glutamicaci
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
• Acide N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamique
• Agpa
• Ai3-26079[Qr]
• Aminopterin
• Aminopterine
• Apga
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
• N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)carbonyl]-D-glutamic acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsaure
• N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• Nsc 739
• Pteramina
• Pteridin-2-Amine

Aminopterin

CAS: 54-62-6

Formula: C₁₉H₂₀N₈O₅

Purezza: >97.0%(T)(HPLC)

Colore e forma: White to Amber powder to crystal

Peso molecolare: 440.42

Ref: 3B-A0410

Methotrexate Related Compound B ((S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid)

CAS: 54-62-6

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₉H₂₀N₈O₅

Colore e forma: White Yellow Powder

Peso molecolare: 440.41

Ref: 45-1414025

Aminopterin dihydrate

CAS: 54-62-6

Formula: C₁₉H₂₀N₈O₅·xH₂O

Purezza: ≥ 97.0%

Colore e forma: Pale yellow to yellow-brown powder

Peso molecolare: 440.41 (anhydrous)

Ref: 7W-GK2974

Aminopterin

CAS: 54-62-6

Aminopterin

Purezza: ≥95%

Peso molecolare: 440.41g/mol

Ref: 54-BUP06495

(2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic Acid (4-Aminofolic Acid, Aminopterin)

Prodotto controllato

CAS: 54-62-6

Formula: C₁₉H₂₀N₈O₅

Colore e forma: Neat

Peso molecolare: 440.41

Ref: 86-MM0040.05

Aminopterin

CAS: 54-62-6

Purezza: 98%

Peso molecolare: 440.420013427734

Ref: 10-F600196

Aminopterin

CAS: 54-62-6

Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase

Formula: C₁₉H₂₀N₈O₅

Purezza: ≥98%

Colore e forma: Orange-Yellow Powder Rodenticide In The U S (Epa 1998)

Peso molecolare: 440.41

Ref: TM-T7730

Methotrexate EP Impurity B (Methotrexate USP Related Compound B)

CAS: 54-62-6

Formula: C₁₉H₂₀N₈O₅

Peso molecolare: 440.42

Ref: 4Z-M-703

Methotrexate EP Impurity B

CAS: 54-62-6

Formula: C₁₉H₂₀N₈O₅

Peso molecolare: 440.42

Ref: ST-EA-CP-M12002

Aminopterin

CAS: 54-62-6

Impurity Methotrexate EP Impurity B
Applications Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),

Formula: C₁₉H₂₀N₈O₅

Colore e forma: Yellow

Peso molecolare: 440.41

Ref: TR-A628850

Aminopterin

CAS: 54-62-6

Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.

Formula: C₁₉H₂₀N₈O₅

Purezza: Min. 97 Area-%

Colore e forma: Slightly Yellow Powder

Peso molecolare: 440.41 g/mol

Ref: 3D-FA17838

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-

CAS: 54-62-6

Formula: C₁₉H₂₀N₈O₅

Colore e forma: Solid

Peso molecolare: 440.4127

Ref: IN-DA00I9N1