CAS 546102-60-7

Cd4k Inhibitor

Prodotto controllato

CAS: 546102-60-7

Formula: C₂₀H₁₀BrN₃O₂

Colore e forma: Neat

Peso molecolare: 404.216

Ref: TR-C228125

Cdk4 Inhibitor

CAS: 546102-60-7

PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.

Formula: C₂₀H₁₀BrN₃O₂

Colore e forma: Solid

Peso molecolare: 404.2

Ref: TM-T84413