CAS 5490-27-7

Solfato di diidrostreptomicina

Descrizione:

Solfato di diidrostreptomicina è un antibiotico aminoglicosidico derivato da Streptomyces griseus, utilizzato principalmente per trattare infezioni batteriche, in particolare quelle causate da Mycobacterium tuberculosis. È caratterizzato dalla sua capacità di inibire la sintesi proteica batterica legandosi alla subunità ribosomiale 30S, portando a una lettura errata dell'mRNA e, infine, alla morte cellulare batterica. Il composto viene tipicamente somministrato per iniezione a causa della sua scarsa biodisponibilità orale. Solfato di diidrostreptomicina è solubile in acqua, il che facilita il suo utilizzo in contesti clinici. La sua struttura chimica include più gruppi amminici, contribuendo alla sua basicità e interazione con i ribosomi batterici. Sebbene sia efficace contro una gamma di batteri Gram-negativi e alcuni Gram-positivi, è importante monitorare i potenziali effetti collaterali, inclusa la nefrotossicità e l'ototossicità, che sono preoccupazioni comuni con gli aminoglicosidi. Come con tutti gli antibiotici, si raccomanda di effettuare test di suscettibilità appropriati per garantire l'efficacia contro patogeni specifici.

Formula: C₂₁H₄₁N₇O₁₂H₂O₄S

InChI: InChI=1S/C21H41N7O12.H2O4S/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;1-5(2,3)4/h5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);(H2,1,2,3,4)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;/m0./s1

InChI key: InChIKey=GSPKOIJAMLDYCY-RMIBZTJPSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@@H]2[C@@H](NC(=N)N)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]2O)O[C@@H](C)[C@@]1(CO)O)[C@H]3[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3

Sinonimi:

• 2,2'-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N,N′-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N¹,N³-bis(aminoiminomethyl)-, sulfate (2:3)
• Didromycin
• Didromycine
• Dihydroestreptomycin Sulphate
• Dihydrostereptomycin Sulfate
• Dihydrostreptomycin 3/2 sulfate
• Dihydrostreptomycin Suflate
• Dihydrostreptomycin Sulfate(2:3)
• Dihydrostreptomycin sesqui-Sulfate
• Dihydrostreptomycin sesquisulfate
• Dihydrostreptomycin sulfate
• Double-mycin
• N'',N'''''-[(1S,2S,3R,4S,5S,6R)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (2:3) (salt)
• Panstreptin
• Sol-Mycin
• Streptomagna
• Streptomycin, dihydro-, sulfate (2:3) (salt)
• D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3)

DIHYDROSTREPTOMYCIN SULFATE CRS

CAS: 5490-27-7

DIHYDROSTREPTOMYCIN SULFATE CRS

Formula: C₂₁H₄₃N₇O₁₆S

Peso molecolare: 681.6684

Ref: 41-D1954000

Dihydrostreptomycin Sulfate

CAS: 5490-27-7

Dihydrostreptomycin and its derivatives; salts thereof

Formula: (C₂₁H₄₁N₇O₁₂)₂·3H₂SO₄

Colore e forma: White Powder

Peso molecolare: 1166.56264

Ref: 45-1203008

Dihydrostreptomycin Sulfate

CAS: 5490-27-7

Formula: C₂₁H₄₁N₇O₁₂·3H₂O₄S

Colore e forma: White To Off-White Solid

Peso molecolare: 2 583.60 3 98.08

Ref: 4Z-S-083005

Dihydrostreptomycin sesquisulfate

CAS: 5490-27-7

Formula: C₂₁H₄₁N₇O₁₂₁·5H₂SO₄

Purezza: ≥ 730IU/mg (anhydrous)

Colore e forma: White to off-white powder

Peso molecolare: 730.71

Ref: 7W-GA8949

Dihydrostreptomycin sesquisulfate

Prodotto controllato

CAS: 5490-27-7

Formula: C₂₁H₄₁N₇O₁₂H₂O₄S

Colore e forma: Neat

Peso molecolare: 1461.42

Ref: 04-C12635300

Dihydrostreptomycin sesquisulfate 100 µg/mL in Acetonitrile/Water

CAS: 5490-27-7

Formula: C₂₁H₄₁N₇O₁₂H₂O₄S

Colore e forma: Single Solution

Peso molecolare: 1461.42

Ref: 04-A12635300WL-100

Dihydrostreptomycin sulfate

CAS: 5490-27-7

Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit.

Formula: C₂₁H₄₁N₇O₁₂·5H₂SO₄

Purezza: 97.38% - 99.9%

Colore e forma: Solid

Peso molecolare: 730.71

Ref: TM-T2211

Dihydrostreptomycin Sesquisulfate

CAS: 5490-27-7

Stability Hygroscopic
Applications A derivative of Streptomycin (S687500) with antimicrobial activity. It is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
References Gradin, J.L. et al.: J. Am. Vet. Med. Assoc., 183, 434 (1983); Bishop, J.R. et al.: J. Dairy Sci., 67, 437 (1984); Singh, D.R. et al.: Obi. Chik. Daig. Gak. Ken. Hok., 11, 475 (1979);

Formula: C₂₁H₄₁N₇O₁₂·3H₂O₄S

Colore e forma: Off-White

Peso molecolare: 1461.42

Ref: TR-D449535

Dihydrostreptomycin sesquisulfate

CAS: 5490-27-7

Dihydrostreptomycin sesquisulfate is an aminoglycoside antibiotic, which is derived from the bacterium Streptomyces griseus. Its mode of action involves binding to the 30S subunit of the bacterial ribosome, leading to the disruption of protein synthesis. This binding interferes with the initiation complex formation, causing misreading of mRNA and ultimately inhibiting bacterial growth.

Formula: C₂₁H₄₁N₇O₁₂•(H₂SO₄)₁

Purezza: Min. 95%

Peso molecolare: 730.71 g/mol

Ref: 3D-AD22045

Dihydrostreptomycin sesquisulfate, EP

CAS: 5490-27-7

Dihydrostreptomycin sesquisulfate, EP is an aminoglycoside antibiotic, structurally derived from Streptomyces griseus. This compound originates from microbial biosynthesis, a method which harnesses the natural antibiotic-producing capabilities of microbial cultures. The mode of action of dihydrostreptomycin sesquisulfate involves binding to the 30S subunit of bacterial ribosomes, which interrupts the process of protein synthesis, ultimately leading to bacterial cell death.

Formula: C₂₁H₄₁N₇O₁₂•(H₂SO₄)₁

Purezza: (Hplc) 94.0 To 102.0%

Colore e forma: Powder

Peso molecolare: 1,461.42 g/mol

Ref: 3D-AD175759