CAS 5511-98-8

α-Acetildigossina

Descrizione:

α-Acetildigossina è un glicoside cardiaco derivato dalla digossina, comunemente usato nel trattamento di condizioni cardiache come la fibrillazione atriale e l'insufficienza cardiaca. Questo composto è caratterizzato dalla sua capacità di inibire l'enzima Na+/K+ ATPasi, portando a un aumento delle concentrazioni di calcio intracellulare e a una maggiore contrattilità cardiaca. α-Acetildigossina ha una formula molecolare che riflette la sua struttura complessa, che include un nucleo steroideo e una porzione zuccherina. Viene tipicamente somministrato in una forma farmaceutica, e la sua farmacocinetica coinvolge processi di assorbimento, distribuzione, metabolismo ed escrezione che sono cruciali per la sua efficacia terapeutica. Il composto presenta una biodisponibilità relativamente alta e una lunga emivita, consentendo una somministrazione una volta al giorno in contesti clinici. Inoltre, α-Acetildigossina può avere una finestra terapeutica più ristretta, richiedendo un attento monitoraggio dei livelli sierici per evitare tossicità. Il suo uso è controindicato in determinate condizioni e può interagire con vari farmaci, evidenziando l'importanza di una comprensione completa del suo profilo farmacologico.

Formula: C₄₃H₆₆O₁₅

InChI: InChI=1S/C43H66O15/c1-20-38(49)32(55-23(4)44)18-37(52-20)58-40-22(3)54-36(17-31(40)46)57-39-21(2)53-35(16-30(39)45)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(47)42(6)27(10-12-43(28,42)50)24-13-34(48)51-19-24/h13,20-22,25-33,35-40,45-47,49-50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1

InChI key: InChIKey=HWKJSYYYURVNQU-DXJNJSHLSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C=3COC(=O)C3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](OC(C)=O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinonimi:

• (3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 3'''-Acetyldigoxin
• 3-{[3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->6)-2,4-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• Acetyl-digoxin-alpha
• Card-20(22)-enolide, 3-((O-3-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
• Card-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Desglucolanatoside C
• Digorid A
• Digoxigenin + zuckerkette wie bie acetyl-digitoxin A
• Digoxigenin + zuckerkette wie bie acetyl-digitoxin A [German]
• Digoxin, 3'''-acetate
• Digoxin, acetate, alpha-
• Digoxin, acetyl-
• Digoxin, α-acetate
• Digoxin, α-acetyl-
• Lanadigin
• Lanatilin
• Sandolanid
• alpha-Acetyldigoxin
• α-Acetyldigoxin
• (3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

Digoxin EP Impurity I

CAS: 5511-98-8

Formula: C₄₃H₆₆O₁₅

Colore e forma: White To Off-White Solid

Peso molecolare: 822.99

Ref: 4Z-D-758

a-Acetyl digoxin

CAS: 5511-98-8

Formula: C₄₃H₆₆O₁₅

Purezza: ≥ 97.0%

Colore e forma: White to off-white or light yellow powder

Peso molecolare: 822.98

Ref: 7W-GC4195

a-Acetyl Digoxin

Prodotto controllato

CAS: 5511-98-8

Applications Digoxin derivative, a cardiotonic glycosides steroid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yoshida, F., et al.: J. Med. Chem., 43, 2575 ( 2000), Turner, J., et al.: Pharm. Res., 21, 68 (2004), Wang, J., et al.: Anal. Chim. Acta, 601, 156 (2007),

Formula: C₄₃H₆₆O₁₅

Colore e forma: Neat

Peso molecolare: 822.98

Ref: TR-A173660

a-Acetyl digoxin

CAS: 5511-98-8

a-Acetyl digoxin is a metabolite of digoxin, a type of cardiac glycoside. It is derived from the parent compound digoxin, which is sourced from the leaves of the Digitalis plant. The modification at the acetyl position renders this metabolite with altered biological properties compared to the original compound. a-Acetyl digoxin acts through inhibition of the Na⁺/K⁺-ATPase pump, similar to digoxin, but does so with significantly reduced activity.

Formula: C₄₃H₆₆O₁₅

Purezza: Min. 95%

Peso molecolare: 822.98 g/mol

Ref: 3D-OA16441

Digoxin EP Impurity I

CAS: 5511-98-8

Formula: C₄₃H₆₆O₁₅

Peso molecolare: 823

Ref: ST-EA-CP-D1200008