CAS 5536-17-4

Vidarabina

Descrizione:

Vidarabina, noto anche come arabinoside di adenina, è un analogo nucleosidico antivirale utilizzato principalmente nel trattamento delle infezioni virali, in particolare del virus herpes simplex e del virus varicella-zoster. È caratterizzato dalla sua struttura, che include un gruppo zuccherino arabinosio legato a una base di adenina, distinguendolo dai nucleosidi naturali. Vidarabina mostra la sua attività antivirale inibendo la sintesi del DNA virale, prevenendo così la replicazione del virus. Il composto è tipicamente somministrato per via endovenosa a causa della sua scarsa biodisponibilità orale. Ha una vita media relativamente breve, richiedendo un attento dosaggio e monitoraggio durante il trattamento. Vidarabina può causare effetti collaterali, inclusa neurotossicità e problemi ematologici, che richiedono considerazione in contesti clinici. Il suo uso è diminuito con l'avvento di agenti antivirali più efficaci, ma rimane un composto significativo nello studio delle terapie antivirali. Come entità chimica, Vidarabina è classificato nella categoria dei nucleosidi purinici e ha un numero CAS specifico, 5536-17-4, utilizzato per la sua identificazione nei database chimici.

Formula: C₁₀H₁₃N₅O₄

InChI: InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(16)1-19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1

InChI key: InChIKey=OIRDTQYFTABQOQ-UHTZMRCNSA-N

SMILES: O[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O

Sinonimi:

• 6-Amino-9-beta-D-arabinofuranosylpurine
• 6-Amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosylpurine
• 6-Amino-9-β-D-arabinofuranosylpurine
• 9-(beta-D-Arabinofuranosyl)-9H-purin-6-amine
• 9-(beta-D-glycero-Pentofuranosyl)-9H-purin-6-amine
• 9-Arabinosyladenine
• 9-beta-D-Arabinofuranosyladenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinoadenosine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-9H-purin-6-amine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyladenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinosyladenine
• 9-β-D-Arabinoadenosine
• 9-β-D-Arabinofuranosyl-9H-purin-6-amine
• 9-β-D-Arabinofuranosyl-adenine
• 9-β-D-Arabinofuranosyladenine
• 9-β-D-Arabinosyladenine
• 9-β-D-arabinopyranosyl-9H-purin-6-amine
• 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-
• 9H-Purin-6-amine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• 9H-Purin-6-amine, 9-β-D-arabinofuranosyl-
• 9H-purin-6-amine, 9-beta-D-glycero-pentofuranosyl-
• Adenine 9-β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Adenine 9-β-D-arabinofuranoside
• Adenine arabinoside
• Adenine β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Adenine β-D-arabinofuranoside
• Adenine, 9-beta-D-arabinofuranosyl-
• Adenine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• Adenine, 9-β-D-arabinofuranosyl-
• Ara-A
• Araadenosine
• Arabinosyladenine
• Arasena-A
• Ci-673
• Nqz-071
• Nsc 247519
• Nsc 404241
• Spongoadenosine
• Vidarabin
• Vidarabina
• Vidarabine anhydrous
• Vira-A
• β-<span class="text-smallcaps">D</span>-Arabinofuranosyladenine
• β-<span class="text-smallcaps">D</span>-Arabinosyladenine
• β-Ara-A
• β-D-Arabinofuranosyladenine
• β-D-Arabinosyladenine
• beta-d-arabinosyladenine
• ADENINE-BETA-D-ARABINOFURANOSIDE
• 9-beta-d-arabinofuranosyl-adenin
• 9-beta-d-arabinofuranosyl-9h-purin-6-amin
• VIDARABINE
• adeninearabinoside
• beta-ara-a
• ci673
• ADENINE-9-BETA-D-ARABINOFURANOSIDE
• ARABINOSYL-ADENINE
• 2'-ARAADENOSINE

Vidarabine

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 267.25

Ref: 3B-V0175

Vidarabine Monohydrate

CAS: 24356-66-9, 5536-17-4

Formula: C₁₀H₁₃N₅O₄·H₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 285.27

Ref: 3B-V0098

9-β-D-Arabinofuranosyladenine, 99%

CAS: 5536-17-4

Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase. Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling. Cell-permeable adenylate cyclase inhibitor;

Formula: C₁₀H₁₃N₅O₄

Purezza: 99%

Peso molecolare: 267.24

Ref: 02-J65076

Vidarabine

CAS: 5536-17-4

Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.

Formula: C₁₀H₁₃N₅O₄

Purezza: 99.85%

Colore e forma: White To Off-White Crystalline Powder

Peso molecolare: 267.24

Ref: TM-T1506

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 267.2413

Ref: IN-DA0034FO

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Adenine 9-β-D-arabinofuranoside

Purezza: 99%

Peso molecolare: 267.24g/mol

Ref: 54-OR1012219

Vidarabine

CAS: 5536-17-4

Vidarabine

Purezza: ≥98%

Peso molecolare: 267.24g/mol

Ref: 54-BUP14712

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purezza: ≥ 99.0%

Colore e forma: White to off-white powder

Peso molecolare: 267.24

Ref: 7W-GA0167

9-(b-D-Arabinofuranosyl)adenine

CAS: 5536-17-4

9-(b-D-Arabinofuranosyl)adenine is a nucleoside that is used as an antiviral agent. It binds to viral RNA and inhibits viral replication. 9-(b-D-Arabinofuranosyl)adenine has been shown to have potent side-effect profiles, including myocardial infarct, neuronal death, and immunological reactions. These effects are due to its ability to inhibit the synthesis of guanine nucleotides in the heart and brain cells, which are essential for energy production and neurotransmitter release respectively. 9-(b-D-Arabinofuranosyl)adenine also binds to toll-like receptors (TLRs), which are proteins found on the surface of cells that recognize invading microbes or foreign substances. This binding leads to activation of immune response pathways.

Formula: C₁₀H₁₃N₅O₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 267.24 g/mol

Ref: 3D-NA06007

(2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purezza: 95%

Colore e forma: Crystalline Powder,Powder

Peso molecolare: 267.245

Ref: 10-F091487

Vidarabine

Prodotto controllato

CAS: 5536-17-4

Applications Vidarabine, is an antiviral drug which is active against herpes simplex and varicella zoster viruses.
References Sneader, W., et al.: Drug Discovery, 258 (2005); Lee, W. W., et al.: J. Am. Chem. Soc., 82, 2648 (1960);

Formula: C₁₀H₁₃N₅O₄

Colore e forma: Neat

Peso molecolare: 267.24

Ref: TR-V305030