CAS 5568-90-1

10H-Fenotiazina-10-etanamina, N,N,β-trimetil-, cloridrato (1:1)

Descrizione:

10H-Fenotiazina-10-etanamina, N,N,β-trimetil-, cloridrato (1:1), comunemente noto come trimetobenzamida, è un composto chimico caratterizzato dalla sua struttura di fenotiazina, che consiste in un sistema triciclico contenente atomi di zolfo e azoto. Questo composto si incontra tipicamente come sale cloridrato, migliorando la sua solubilità in acqua e rendendolo adatto per applicazioni farmaceutiche. Presenta proprietà come antiemetico, utilizzato principalmente per prevenire nausea e vomito associati a varie condizioni, inclusi stati post-operatori e chemioterapia. Il gruppo trimetilammina contribuisce alla sua attività farmacologica, influenzando la sua interazione con i recettori dei neurotrasmettitori nel sistema nervoso centrale. In termini di proprietà fisiche, è solitamente una polvere cristallina bianca o bianco sporco, con un intervallo specifico di punto di fusione e profilo di solubilità. I dati di sicurezza indicano che, come molti farmaci, deve essere maneggiato con cura, poiché può causare effetti collaterali o interazioni con altri farmaci. In generale, la sua struttura e le sue proprietà uniche lo rendono un composto significativo nella chimica medicinale.

Formula: C₁₇H₂₁ClN₂S

InChI: InChI=1/C17H20N2S.ClH/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

InChI key: InChIKey=RISCHQYUHLQSBU-UHFFFAOYSA-N

SMILES: C(CN(C)C)(C)N1C=2C(SC=3C1=CC=CC3)=CC=CC2.Cl

Sinonimi:

• 10H-Phenothiazine-10-ethanamine, N,N,beta-trimethyl-, monohydrochloride (9CI)
• 10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1)
• 10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, monohydrochloride
• Isopromethazine hydrochloride
• Phenothiazine, 10-[2-(dimethylamino)-1-methylethyl]-, monohydrochloride
• Promethazine Impurity B (Isopromethazine) HCl
• Promethazine Impurity 2(EP Impurity B)
• N,N-dimethyl-2-phenothiazin-10-ylpropan-1-amine:hydrochloride
• Promethazine Impurity B
• PROMETHAZINE EP IMPURITY B HCL (ISOPROMETHAZINE HCL)
• ProMethazine EP IMpurity B
• N,N-dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine
• Promethazine EP Impurity B/ Promethazine Related Compound B (Isopromethazine)
• Promethazine Impurity 2(Promethazine EP Impurity B)

Isopromethazine hydrochloride

CAS: 5568-90-1

Isopromethazine hydrochloride

Colore e forma: White To Off-White

Ref: 47-778

Promethazine Related Compound B (N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride)

CAS: 5568-90-1

Compounds (excluding drugs) containing a phenothiazine ring-system (whether or not hydrogenated), not further fused

Formula: C₁₇H₂₀N₂S·HCl

Colore e forma: White Powder

Peso molecolare: 320.1114

Ref: 45-1570029

Promethazine EP Impurity B HCl (Promethazine USP Related Compound B, Isopromethazine HCl)

CAS: 5568-90-1

Formula: C₁₇H₂₀N₂S·HCl

Colore e forma: Gray Solid

Peso molecolare: 284.42 36.46

Ref: 4Z-P-186

Promethazine EP Impurity B (as Hydrochloride)

Prodotto controllato

CAS: 5568-90-1

Formula: C₁₇H₂₀N₂S·ClH

Colore e forma: Neat

Peso molecolare: 320.88

Ref: 86-MM0412.02

Iso Promethazine Hydrochloride

CAS: 5568-90-1

Impurity Promethazine EP Impurity B
Stability Hygroscopic
Applications Iso Promethazine Hydrochloride (Promethazine EP Impurity B) is a Promethazine (P757000) impurity.
References Gasco, M.R., et al.: J. Pharma. Sci., 68, 612 (1979),

Formula: C₁₇H₂₀N₂S·ClH

Colore e forma: White To Off-White

Peso molecolare: 320.88

Ref: TR-I822500

Promethazine related compound B

CAS: 5568-90-1

Promethazine is a phenothiazine derivative that is used as an antihistamine and antipsychotic. It has been found to bind to the H1 receptor, which may be the mechanism by which it inhibits histamine release. Promethazine also binds to the H2 receptor, which may be the mechanism by which it inhibits acid secretion in the stomach. Promethazine has been shown to have antiviral properties against herpes simplex virus type 1 (HSV-1) and human immunodeficiency virus (HIV). Promethazine can bind to metal ions and form a neutral complex that can inhibit receptors on cells. The drug has been shown to inhibit receptors for acetylcholine, dopamine, GABA, serotonin, histamine, and norepinephrine.

Formula: C₁₇H₂₀N₂S•HCl

Purezza: Min. 95 Area-%

Colore e forma: Powder

Peso molecolare: 320.88 g/mol

Ref: 3D-FAA56890

Promethazine EP Impurity B

CAS: 5568-90-1

Formula: C₁₇H₂₀N₂SHCl

Peso molecolare: 284.42 : 36.46

Ref: ST-EA-CP-P86002