CAS 5579-84-0

Dicloridrato di betahistina

Descrizione:

Dicloridrato di betahistina è un analogo dell'istamina utilizzato principalmente nel trattamento della malattia di Ménière e di altri disturbi vestibolari. Agisce come un agonista selettivo per i recettori H1 dell'istamina e un antagonista per i recettori H3, il che aiuta a migliorare il flusso sanguigno nell'orecchio interno e a ridurre sintomi come vertigini e acufeni. La sostanza è tipicamente somministrata per via orale ed è nota per la sua relativamente buona biodisponibilità. Chimicamente, è caratterizzata dalla sua forma di sale di diidrocloruro, che ne migliora la solubilità in acqua. Dicloridrato di betahistina è generalmente ben tollerato, con effetti collaterali comuni che includono disturbi gastrointestinali e mal di testa. Il suo meccanismo d'azione implica la modulazione del rilascio di neurotrasmettitori e il miglioramento della microcircolazione nell'orecchio interno, contribuendo ai suoi effetti terapeutici. Il composto è classificato nella categoria degli antistaminici, sebbene non presenti le proprietà sedative comunemente associate a molti altri farmaci di questa classe. In generale, Dicloridrato di betahistina è un farmaco prezioso per la gestione dei disturbi dell'equilibrio legati alla disfunzione dell'orecchio interno.

Formula: C₈H₁₄Cl₂N₂

InChI: InChI=1/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H

InChI key: InChIKey=XVDFMHARQUBJRE-UHFFFAOYSA-N

SMILES: C(CNC)C1=CC=CC=N1.Cl

Sinonimi:

• 2-Pyridineethanamine, N-methyl-, dihydrochloride
• 2-Pyridineethanamine, N-methyl-, hydrochloride (1:2)
• Betahistine dihydrochloride
• Betahistine hydrochloride
• Betaserc
• N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride
• Pyridine, 2-[2-(methylamino)ethyl]-, dihydrochloride
• Sinmenier
• Vasomotal
• PT 9
• 2-(2-(METHYLAMINO)ETHYL)PYRIDINE DIHYDROCHLORIDE 99%
• n-methyl-2-pyridineethanamindihydrochloride
• 2-(BETA-METHYLAMINOETHYL)PYRIDINE DIHYDROCHLORIDE
• METHYL[2-(2-PYRIDYL)ETHYL]AMINE DIHYDROCHLORIDE
• Betahistine Hydrochloride CP2000
• BetahistineHCl
• BETAHISTINE DIHYDROCHLORIDE:METHYL(2-[2-PYRIDYL]ETHYL)AMINE
• 2-(2-(METHYLAMINO)ETHYL)PYRIDINE DIHYDROCHLORIDE
• BETAHISTINE DIHYDROCHLORIDE (2-(2-(METHYLAMINO)ETHYL)PYRIDINE DIHYDROCHLORIDE)
• Betahistine 2 hcl
• Serc
• BETA-HISTINE DIHDROCHLORIDE
• N-Methyl-2-pyridin-2-ylethanamine dihydrochloride
• Microser

Betahistine dihydrochloride

CAS: 5579-84-0

Betahistine dihydrochloride

Formula: C₈H₁₂N₂HCl

Purezza: 99.5%

Colore e forma: White. To. Off-White

Peso molecolare: 172.07673

Ref: 47-824

BETAHISTINE DIHYDROCHLORIDE CRS

CAS: 5579-84-0

BETAHISTINE DIHYDROCHLORIDE CRS

Formula: C₈H₁₄Cl₂N₂

Colore e forma: White. Whitish. Powder.

Peso molecolare: 209.1162

Ref: 41-Y0000391

Betahistine Hydrochloride

CAS: 5579-84-0

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₈H₁₂N₂·2HCI

Colore e forma: White Light Yellow Crystalline Powder

Peso molecolare: 415.92464

Ref: 45-1065618

2-Pyridineethanamine, N-methyl-, dihydrochloride

CAS: 5579-84-0

Formula: C₈H₁₄Cl₂N₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 209.1162

Ref: IN-DA00I9YC

Betahistine-13C-d3 DiHCl

CAS: 5579-84-0, 5638-76-6

Formula: C₇₁₃CH₉D₃N₂·2HCl

Colore e forma: Pale Orange Solid

Peso molecolare: 140.21 2*36.46

Ref: 4Z-B-364

Betahistine Dihydrochloride

CAS: 5579-84-0

Betahistine Dihydrochloride

Purezza: 98%

Peso molecolare: 209.12g/mol

Ref: 54-OR1012385

Betahistine Dihydrochloride, 10mM (in DMSO)

CAS: 5579-84-0

Betahistine Dihydrochloride, 10mM (in DMSO)

Purezza: ≥98%

Peso molecolare: 209.12g/mol

Ref: 54-BUP18938

Betahistine DiHCl

CAS: 5579-84-0

Formula: C₈H₁₂N₂·2HCl

Colore e forma: Pale Orange Solid

Peso molecolare: 136.20 2*36.46

Ref: 4Z-B-368

Betahistine Dihydrochloride

CAS: 5579-84-0

Colore e forma: Neat

Ref: 86-MM0587.00

Betahistine dihydrochloride

CAS: 5579-84-0

Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.

Formula: C₈H₁₄Cl₂N₂

Purezza: 99.22% - 99.88%

Colore e forma: White To Light Yellow Crystalline Powder

Peso molecolare: 209.12

Ref: TM-T0246

Betahistine Dihydrochloride

CAS: 5579-84-0

Formula: C₈H₁₂N₂(HCl)

Peso molecolare: 136.2 : 2(36.46)

Ref: ST-EA-CP-B11007

Betahistine Dihydrochloride

CAS: 5579-84-0

Applications Betahistine is most commonly used to treat the symptoms of Ménière's disease and vertigo. Vasodilator.
References Gilligan, P., et al.: J. Med. Chem., 43, 1641 (2000), Keller, P., et al.: Bioorg. Med. Chem., 8, 1213 (2000), Hauger, R., et al.: Pharmacol. Rev., 55, 21 (2003), Han, X., et al.: Bioorg. Med. Chem. Lett., 15, 3870 (2005),

Formula: C₈H₁₂N₂·2ClH

Colore e forma: Neat

Peso molecolare: 209.12

Ref: TR-B324001

Betahistine dihydrochloride

CAS: 5579-84-0

Betahistine dihydrochloride is a medication used to treat Ménière's disease, vertigo, and dizziness. It is an antihistamine that acts on histamine H1 receptors in the vestibular system. Betahistine also has vasodilatory effects, which are mediated by its ability to activate the α-adrenergic receptors in the vascular endothelium. This drug is approved for use as a treatment for Ménière's disease and vertigo, but is not approved for treating dizziness. Betahistine dihydrochloride can be administered either intravascularly or orally. The drug undergoes a phase transition from liquid to solid at low temperatures, so it should be stored at room temperature in sealed ampoules and vials to prevent crystallization. Treatment trials have shown that low-dose betahistine (less than 40 mg) may be as effective as higher doses of betahistine (40-120 mg) in the

Formula: C₈H₁₂N₂·2HCl

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 209.12 g/mol

Ref: 3D-FB138972

N-methyl-N-(2-pyridin-2-ylethyl)amine dihydrochloride

CAS: 5579-84-0

Formula: C₈H₁₄Cl₂N₂

Purezza: 95+%

Colore e forma: Solid

Peso molecolare: 209.11

Ref: 10-F351346