CAS 55981-09-4

Nitazoxanide

Descrizione:

Nitazoxanide è un composto antiparassitario e antivirale utilizzato principalmente nel trattamento di varie infezioni, comprese quelle causate da protozoi e alcuni virus. È classificato come un tiazolide e presenta un ampio spettro di attività contro una varietà di patogeni. La struttura chimica di Nitazoxanide presenta un anello di tiazolo, che contribuisce alle sue proprietà farmacologiche. Agisce inibendo l'enzima piruvato:ferredossina ossidoreduttasi, interrompendo il metabolismo energetico degli organismi bersaglio. Nitazoxanide è tipicamente somministrato per via orale ed è noto per il suo profilo di tossicità relativamente basso. Viene spesso utilizzato in combinazione con altri farmaci per migliorare l'efficacia terapeutica. Il composto è anche oggetto di indagine per il suo potenziale utilizzo contro varie infezioni virali, tra cui influenza e coronavirus. La sua solubilità e stabilità in diversi ambienti di pH lo rendono adatto per la formulazione in varie forme di dosaggio. In generale, Nitazoxanide rappresenta un significativo progresso nel trattamento delle malattie infettive, evidenziando l'importanza dei composti chimici nella medicina moderna.

Formula: C₁₂H₉N₃O₅S

InChI: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChI key: InChIKey=YQNQNVDNTFHQSW-UHFFFAOYSA-N

SMILES: C(NC=1SC(N(=O)=O)=CN1)(=O)C2=C(OC(C)=O)C=CC=C2

Sinonimi:

• 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
• 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• Alinia
• Brn 1225475
• Cryptaz
• Daxon
• Dexidex
• Drg 0242
• Kidonax
• Mitafar
• N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester)
• NTX
• NTZ
• Nitacure
• Nitacure 500
• Nitarid
• Nitazode
• Nitazox 500
• Nitazoxanida
• Nitazoxanide
• Nixide
• Nixoran
• Nizonide
• Nsc 697855
• Pacovanton
• ParaMix
• Ph 5776
• Xerovirin-C
• acetate de o-[N-(5-nitrothiazole-2-yl)carbamoyl]phenyle
• acetato de o-[N-(5-nitrotiazol-2-il)carbamoil]fenilo
• o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat
• o-[N-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate

Nitazoxanide

CAS: 55981-09-4

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₁₂H₉N₃O₅S

Colore e forma: Light Yellow Yellow Powder

Peso molecolare: 307.02629

Ref: 45-1463960

Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 307.2820

Ref: IN-DA00I9ZK

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide (NSC-697855) is a synthetic benzamide antiprotozoal; it disrupts pyruvate electron transfer reactions.

Formula: C₁₂H₉N₃O₅S

Purezza: 99% - 99.93%

Colore e forma: Solid

Peso molecolare: 307.28

Ref: TM-T1546

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide

Purezza: 99%

Peso molecolare: 307.28g/mol

Ref: 54-OR1025226

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Peso molecolare: 307.29

Ref: 4Z-N-169001

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide

Purezza: ≥95%

Peso molecolare: 307.28g/mol

Ref: 54-BUP17783

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 307.28

Ref: 3B-N1031

Nitazoxanide

Prodotto controllato

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Colore e forma: Neat

Peso molecolare: 307.28

Ref: 86-MM3279.00

Nitrazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Colore e forma: Neat

Peso molecolare: 307.28

Ref: 04-C15552000

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Peso molecolare: 307.28

Ref: 7W-GP0229

Nitazoxanide

Prodotto controllato

CAS: 55981-09-4

Applications An anthelmintic (cestodes), antiprotozoal (cryptosporidium). Kills Mycobacterium tuberculosis.
References Cavier, R., et al.: Eur. J. Med. Chem.-Chim. Ther., 13, 539 (1978), Dubreuil, L., et al.: Antimicrob. Ag. Chemother., 40, 2266 (1996), Stockis, A., et al.: Int. J. Clin. Pharmacol. Ther., 34, 349 (1996), Nathan, C., et al.: J. Med. Chem. 52, 5789 (2009); de Carvalho et. al., J. Med. Chem., 52, 5789 (2009)

Formula: C₁₂H₉N₃O₅S

Colore e forma: Light Yellow Crystalline

Peso molecolare: 307.28

Ref: TR-N490100

Nitazoxanide - Bio-X ™

CAS: 55981-09-4

Nitazoxanide acts as a noncompetitive inhibitor of the pyruvate: ferredoxin/flavodoxin oxidoreductases of various microorganism with Ki values between 2 and 10 μM. Nitazoxanide is clinically relevant for its broad-spectrum action to reduce the growth of bacteria, various parasites, and especially for its efficacy against the pathogen Helicobacter pylori. Nitazoxanide also has been shown to be effective in treating inflammatory bowel disease and acute enteritis caused by bacteria. In 2021, nitazoxanide was tested for the treatment of COVID-19 patients with mild symptoms due to its broad antiviral action.

Formula: C₁₂H₉N₃O₅S

Purezza: Min. 90 Area-%

Colore e forma: Powder

Peso molecolare: 307.28 g/mol

Ref: 3D-BN164151

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Purezza: 95.0%

Colore e forma: Crystalline Powder,Powder

Peso molecolare: 307.28

Ref: 10-F076695

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide is a prodrug that is converted to the active form, nitazoxanide triacetate, in the stomach. It inhibits the growth of infectious agents by preventing their synthesis of DNA, RNA, or protein. Nitazoxanide has been shown to be effective against persistent strains of influenza A (H1N1) and A (H3N2) as well as rotavirus. It also has been shown to have a low toxicity profile in human clinical trials. Nitazoxanide is not an anti-inflammatory agent and does not inhibit cyclooxygenase enzymes. The drug can potentially be used for treatment of cancer due to its ability to inhibit mitochondrial membrane potential, which may lead to cell death.

Formula: C₁₂H₉N₃O₅S

Purezza: Min. 98 Area-%

Colore e forma: White Slightly Yellow Powder

Peso molecolare: 307.28 g/mol

Ref: 3D-FN26229