CAS 56377-79-8

Nosiheptide

Descrizione:

Nosiheptide è un antibiotico peptidico ciclico che appartiene alla classe dei tiopeptidi, noti per le loro caratteristiche strutturali uniche e potenti attività biologiche. È prodotto da ceppi specifici del batterio *Nocardia*, e la sua struttura include una serie di amminoacidi legati da legami peptidici, spesso presentando amminoacidi insoliti e un anello di tiazolo o ossazolo. Nosiheptide mostra forti proprietà antibatteriche, in particolare contro batteri Gram-positivi, rendendolo di interesse nel campo della chimica medicinale e dello sviluppo di antibiotici. Il suo meccanismo d'azione coinvolge tipicamente l'inibizione della sintesi proteica legandosi all'RNA ribosomiale, interrompendo il processo di traduzione. Inoltre, a causa della sua struttura complessa, Nosiheptide è stato studiato per le sue potenziali applicazioni nel trattamento di infezioni causate da ceppi resistenti agli antibiotici. La ricerca sulle sue proprietà farmacologiche, biosintesi e potenziali usi terapeutici continua a essere un'area di indagine attiva, evidenziando l'importanza dei prodotti naturali nella scoperta di farmaci.

Formula: C₅₁H₄₃N₁₃O₁₂S₆

InChI: InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)

InChI key: InChIKey=OQAOHXRUMXWDLQ-UHFFFAOYSA-N

SMILES: OC=1C=C2C(C=3N=C(SC3)C4NC(=O)C=5N=C(SC5)C(NC(=O)C=6N=C(C(=CC)NC(=O)C(C(C)O)NC(=O)C=7N=C2SC7)SC6)CC(O)C(=O)OCC8=C9C(C)=C(C(=O)SC4)NC9=CC=C8)=NC1C%10=NC(C(NC(C(N)=O)=C)=O)=CS%10

Sinonimi:

• Multhiomycin
• 30,32-Imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontine, nosiheptide deriv.
• Nosiheptide
• N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide
• 4-Thiazolecarboxamide, N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-

4-Thiazolecarboxamide,N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2

CAS: 56377-79-8

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 1222.3570

Ref: IN-DA01CBUM

Nosiheptide

CAS: 56377-79-8

Nosiheptide, a thiopeptide antibiotic from Streptomyces actuosus, boosts animal growth; it blocks protein synthesis in bacteria.

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Purezza: 95.37%

Colore e forma: Solid

Peso molecolare: 1222.36

Ref: TM-T16340

Nosiheptide

CAS: 56377-79-8

Nosiheptide

Purezza: ≥95%

Peso molecolare: 1222.36g/mol

Ref: 54-BUP05380

N-(3-Amino-3-Oxoprop-1-En-2-Yl)-2-((11S,14Z,21S,23S,29S)-14-Ethylidene-3,23-Dihydroxy-11-((1R)-(1-Hydroxyethyl))-31-Methyl-9,12,19,24,33,43-Hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-Hexad

CAS: 56377-79-8

N-(3-Amino-3-Oxoprop-1-En-2-Yl)-2-((11S,14Z,21S,23S,29S)-14-Ethylidene-3,23-Dihydroxy-11-((1R)-(1-Hydroxyethyl))-31-Methyl-9,12,19,24,33,43-Hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-Hexad

Purezza: 90%

Peso molecolare: 1222.36g/mol

Ref: 54-OR1023930

Nosiheptide 100 µg/mL in Acetonitrile:Dimethylsulfoxide

CAS: 56377-79-8

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Colore e forma: Single Solution

Peso molecolare: 1222.36

Ref: 04-A15652500DL-100

Nosiheptide (Standard)

CAS: 56377-79-8

Nosiheptide (Standard) is the standard substance of Nosiheptide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nosiheptide (Multhiomycin), a thiopeptide antibiotic synthesized by Streptomyces actuosus, serves as a potent feed additive to promote animal growth. It functions by hindering bacterial protein synthesis and is distinguished by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Peso molecolare: 1222.36

Ref: TM-TMSM-1776

Nosiheptide

CAS: 56377-79-8

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Peso molecolare: 1222.34

Ref: 4Z-PN-172001

Nosiheptide

CAS: 56377-79-8

A thiopeptide antibiotic produced by the bacterium Streptomyces actuosus. In addition, nosiheptide inhibits bacterial protein biosynthesis by acting during the elongation of the protein.

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,222.36 g/mol

Ref: 3D-FA76383

Nosiheptide (>85%)

CAS: 56377-79-8

Applications Nosiheptide is an antibacterial item used in feedstock and feed additives for chickens.
References Wang, H. et al.: J. Sci. Food. Agri., 93, 284 (2013); Kobayashi, I. et al.: Res. Dev. Rev., 2, 53 (1988);

Formula: C₅₁H₄₃N₁₃O₁₂S₆

Colore e forma: Neat

Peso molecolare: 1222.36

Ref: TR-N884000