CAS 564-36-3

Ergocornina

Descrizione:

Ergocornina è un alcaloide che si verifica naturalmente ed è derivato dal fungo ergot, specificamente dalla specie Claviceps purpurea. Fa parte del gruppo più ampio degli alcaloidi dell'ergot, noti per le loro strutture complesse e le diverse attività biologiche. Ergocornina è caratterizzato dalla sua struttura tetraciclica, che include un telaio di indolo e isoquinolina fusi. Questo composto presenta varie proprietà farmacologiche, tra cui vasocostrizione ed effetti sui sistemi di neurotrasmettitori, in particolare in relazione alla serotonina e alla dopamina. Ergocornina è stato studiato per le sue potenziali applicazioni terapeutiche, incluso il suo ruolo nel trattamento dell'emicrania e di altri disturbi vascolari. Tuttavia, è anche associato a effetti avversi, in particolare quando derivato da cereali contaminati, portando all'ergotismo. Il composto si trova tipicamente in forma cristallina ed è solubile in solventi organici. Le sue proprietà chimiche e attività biologiche lo rendono un argomento di interesse sia in farmacologia che in tossicologia. Come per molti alcaloidi, le considerazioni sulla sicurezza e sul dosaggio sono cruciali quando si esplorano le sue applicazioni.

Formula: C₃₁H₃₉N₅O₅

InChI: InChI=1/C31H39N5O5/c1-16(2)26-28(38)35-11-7-10-24(35)31(40)36(26)29(39)30(41-31,17(3)4)33-27(37)19-12-21-20-8-6-9-22-25(20)18(14-32-22)13-23(21)34(5)15-19/h6,8-9,12,14,16-17,19,23-24,26,32,40H,7,10-11,13,15H2,1-5H3,(H,33,37)/t19-,23-,24+,26+,30-,31+/m1/s1

InChI key: InChIKey=UJYGDMFEEDNVBF-OGGGUQDZSA-N

SMILES: O[C@]12N(C(=O)[C@@](NC(=O)[C@@H]3C=C4C=5C=6C(C[C@]4(N(C)C3)[H])=CNC6C=CC5)(C(C)C)O1)[C@@H]([C@@H](C)C)C(=O)N7[C@]2(CCC7)[H]

Sinonimi:

• Ergocornine
• Ergotaman-3′,6′,18-trione, 12′-hydroxy-2′,5′-bis(1-methylethyl)-, (5′α)-
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• (5′α)-12′-Hydroxy-2′,5′-bis(1-methylethyl)ergotaman-3′,6′,18-trione
• 12′-Hydroxy-2′,5′-α-bis(1-methyl-ethyl)ergotaman-3′,6′,18-trion
• ERGOCORNINE >95% DOPAMINE RECEPTOR AGO
• ergocornin
• (5'alpha)-12'-Hydroxy-2',5'-bis(1-methylethyl)ergotaman-3',6',18-trione
• 12'-HYDROXY-2',5'-ALPHA-BIS(1-METHYL-ETHYL)ERGOTAMAN-3',6',18-TRIONE
• (5'α)-12'-Hydroxy-2',5'-bis(1-Methylethyl)ergotaMan-3',6',18-trione
• Ergotaman-3',6',18-trione, 12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'α)-
• 18-trione,12’-hydroxy-2’,5’-bis(1-methylethyl)-6(5’-alpha)-ergotaman-3
• NSC 407316
• ERGOCORNINE USP/EP/BP
• Ergot Cornyn
• 12'-Hydroxy-2',5'α-diisopropylergotaman-3',6',18-trione

Ergocornine

CAS: 564-36-3

Ergocornine is a naturally occurring ergot alkaloid and acts as a dopamine receptor (dopamine receptor) agonist.

Formula: C₃₁H₃₉N₅O₅

Colore e forma: Solid

Peso molecolare: 561.67

Ref: TM-TN8447

Ergocornine

Prodotto controllato

CAS: 564-36-3

Formula: C₃₁H₃₉N₅O₅

Colore e forma: Neat

Peso molecolare: 561.67

Ref: 04-C13201200

N-Nitroso Ergocorninine

CAS: 564-36-3

Formula: C₃₁H₃₈N₆O₆

Peso molecolare: 590.68

Ref: 4Z-E-185002

Ergocornine

CAS: 564-36-3

Formula: C₃₁H₃₉N₅O₅

Peso molecolare: 561.68

Ref: 4Z-E-220001

Ergocornine

Prodotto controllato

CAS: 564-36-3

Applications Ergocornine is a natural ergot alkaloid derived from lysergic acid. Ergocornine is a component of Ergotoxine. Ergocornine is isolated from Ergot.
References Bhat, R., et al.: Toxicol. Appl. Pharmacol., 36, 11 (1976), Komarova, E., et al.: Pharm. Chem. J., 35, 542 (2001), Krska, R., et al.: Anal. Bioanal. Chem., 391, 563 (2008), Frenich, A., et al.: Food Chem., 117, 705 (2009),

Formula: C₃₁H₃₉N₅O₅

Colore e forma: Neat

Peso molecolare: 561.67

Ref: TR-E597350

Ergocornine

Prodotto controllato

CAS: 564-36-3

Ergocornine is an ergoline alkaloid, which is a naturally occurring compound found in ergot fungi, specifically Claviceps species. These fungi predominantly infect cereal grains such as rye, leading to the production of a variety of ergot alkaloids. Ergocornine acts mainly by interacting with adrenergic receptors, displaying affinity for both alpha-adrenergic and serotonin receptor subtypes. This interaction results in vasoconstrictive and neuromodulatory effects, primarily impacting vascular and smooth muscle tissues.Ergocornine and related alkaloids have been studied extensively for their pharmacological properties. They are of particular interest due to their potential applications in treating conditions such as migraines, where the vasoconstrictive properties can mitigate the symptoms. Additionally, their effects on smooth muscles make them candidates for research in uterine contraction regulation during labor. However, due to the potent nature of these compounds and potential for toxicity, their clinical applications require careful consideration of dosage and delivery systems. Scientists continue to explore ergocornine's pharmacodynamics to better understand its therapeutic potential and safety profile.

Formula: C₃₁H₃₉N₅O₅

Purezza: Min. 95%

Peso molecolare: 561.67 g/mol

Ref: 3D-FE30655