CAS 571190-30-2
:Palbociclib
Descrizione:
Palbociclib è un farmaco orale classificato come inibitore selettivo delle chinasi dipendenti dalle cicline 4 e 6 (CDK4/6), utilizzato principalmente nel trattamento del cancro al seno positivo ai recettori ormonali e negativo per il recettore 2 del fattore di crescita epidermico umano. La sua formula chimica è C24H29N5O2 e presenta una struttura complessa che include un anello di piridazina, cruciale per la sua attività biologica. Palbociclib agisce interrompendo il ciclo cellulare, inibendo specificamente la transizione dalla fase G1 alla fase S, prevenendo così la proliferazione delle cellule tumorali. La sostanza viene tipicamente somministrata in combinazione con inibitori dell'aromatasi o antagonisti del recettore degli estrogeni per migliorare l'efficacia terapeutica. Palbociclib è caratterizzato dalla sua solubilità moderata nei solventi organici e dalla relativa bassa solubilità in acqua, il che può influenzare la sua biodisponibilità. La sua farmacocinetica indica un significativo metabolismo di primo passaggio, principalmente da parte del fegato, e ha una emivita che supporta la somministrazione una volta al giorno. Come per molte terapie mirate, è essenziale monitorare gli effetti collaterali come la neutropenia durante il trattamento.
Formula:C24H29N7O2
InChI:InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChI key:InChIKey=AHJRHEGDXFFMBM-UHFFFAOYSA-N
SMILES:O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5
Sinonimi:- 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
- 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
- Ibrance
- Otava-Bb 1115529
- Palbociclib
- Palbociclib base
- Palbocyclib
- Pd 332991
- Pd 991
- Pd-0332991
- Pd0332991
- Vedi altri sinonimi
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16 prodotti.
Palbociclib
CAS:Formula:C24H29N7O2Purezza:>97.0%(T)(HPLC)Colore e forma:White to Yellow to Yellow green powder to crystalPeso molecolare:447.54Palbociclib
CAS:Formula:C24H29N7O2Purezza:(TLC) ≥ 98.0%Colore e forma:Yellow powderPeso molecolare:447.53Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formula:C24H29N7O2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:447.53Palbociclib Sulfate Sodium Salt
CAS:Prodotto controllato<p>Applications Palbociclib Sulfate is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C24H28N7NaO5SColore e forma:NeatPeso molecolare:549.58Palbociclib-d4
CAS:Prodotto controllato<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C24H25D4N7O2Colore e forma:Light YellowPeso molecolare:451.56Palbociclib - Bio-X ™
CAS:<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C24H29N7O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:447.53 g/molPalbociclib
CAS:<p>Selective and potent inhibitor of cyclin-dependent kinases CDK4 and CDK6. It blocks cell cycle progression from phase G1 into S by inhibiting CDK4/6-dependent retinoblastoma (RB) phosphorylation. It has been used for the treatment of HER2 negative, estrogen receptor (ER) positive metastatic breast cancer.</p>Formula:C24H29N7O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:447.53 g/molPalbociclib-d4 Hydrochloride
CAS:Prodotto controllato<p>Applications Palbociclib-d4 Hydrochloride is an intermediate in synthesizing Palbociclib-d4 (P139901), an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C25H27D4N7O2·HClColore e forma:NeatPeso molecolare:465.58 + (36.46)Palbociclib N-β-D-Glucuronide Sodium Salt (Technical Grade, ~65%)
CAS:Prodotto controllato<p>Applications Palbociclib N-β-D-Glucuronide is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C30H36N7NaO8Purezza:~65%Colore e forma:NeatPeso molecolare:645.64Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Formula:C24H29N7O2Colore e forma:NeatPeso molecolare:447.53Maillard Product
CAS:Prodotto controllatoFormula:C36H49N7O12Colore e forma:NeatPeso molecolare:771.8146-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
CAS:Formula:C24H29N7O2Colore e forma:SolidPeso molecolare:447.5328
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