CAS 578-76-7

7-Metilguanina

Descrizione:

7-Metilguanina è una nucleobase modificata che gioca un ruolo significativo nella struttura e nella funzione degli acidi nucleici. È un derivato della guanina, in cui un gruppo metile è attaccato all'atomo di azoto nella posizione 7 dell'anello purinico. Questa modifica può influenzare la stabilità e le proprietà di accoppiamento degli acidi nucleici, in particolare nell'RNA, dove spesso si trova nella struttura del cappuccio dell'mRNA, contribuendo alla stabilità dell'mRNA e all'efficienza della traduzione. La presenza di 7-Metilguanina può anche influenzare l'espressione genica e i processi cellulari. In termini di proprietà fisiche, è tipicamente un solido cristallino bianco a bianco sporco, solubile in acqua e solventi organici. La sua formula molecolare è C6H7N5O e ha un peso molecolare che riflette la sua composizione di carbonio, idrogeno, azoto e ossigeno. 7-Metilguanina è di interesse nella ricerca biochimica e ha implicazioni negli studi relativi all'epigenetica e alla regolazione dell'espressione genica.

Formula: C₆H₇N₅O

InChI: InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)

InChI key: InChIKey=FZWGECJQACGGTI-UHFFFAOYSA-N

SMILES: O=C1C2=C(NC(N)=N1)N=CN2C

Sinonimi:

• 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one
• 2-Amino-7-methyl-1H-purin-6(7H)-one
• 2-Amino-7-methyl-3H-purin-6-one
• 2-Amino-7-methyl-6,7-dihydro-1H-purin-6-one
• 2-Amino-7-methyl-6,7-dihydro-3H-purin-6-one
• 2-Amino-7-methyl-7H-purin-6-ol
• 2-Amino-7-methylhypoxanthine
• 2-Imino-7-methyl-2,3,6,7-tetrahydro-1H-purin-6-one
• 2-amino-7-methyl-3,7-dihydro-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
• Guanine, 7-methyl-
• N(sup 7)-Methylguanine
• N7-Methylguanine
• N⁷-Methylguanine
• NSC 19647
• Nsc 193444

7-Methylguanine

CAS: 578-76-7

Formula: C₆H₇N₅O

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 165.16

Ref: 3B-M3490

6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-

CAS: 578-76-7

Formula: C₆H₇N₅O

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 165.1527

Ref: IN-DA00IAAH

7-Methylguanine

CAS: 578-76-7

7-Methylguanine

Purezza: 95%

Peso molecolare: 165.15g/mol

Ref: 54-OR1025745

7-Methylguanine

CAS: 578-76-7

7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, anticancer. a natural nucleic acid metabolite.

Formula: C₆H₇N₅O

Purezza: 99.99%

Colore e forma: Solid

Peso molecolare: 165.15

Ref: TM-T10194

7-Methylguanine

CAS: 578-76-7

Ref: 7W-GW0899

7-Methylguanine

CAS: 578-76-7

Applications Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.
References Fernandez, J. et al.; Bioorg. Med. Chem.; 18, 6748 (2010); Li, H. et al.; J. Mass. Spectrom. 44, 641 (2009)

Formula: C₆H₇N₅O

Colore e forma: White Powder

Peso molecolare: 165.15

Ref: TR-M311790

7-Methylguanine

CAS: 578-76-7

Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, top

Formula: C₆H₇N₅O

Purezza: Min. 95 Area-%

Colore e forma: Slightly Brown Powder

Peso molecolare: 165.15 g/mol

Ref: 3D-FM73256

2-Amino-7-methyl-1H-purin-6(7H)-one

CAS: 578-76-7

Formula: C₆H₇N₅O

Purezza: 98%

Peso molecolare: 165.156

Ref: 10-F235617

7-Methylguanine

CAS: 578-76-7

Formula: C₆H₇N₅O

Peso molecolare: 165.16

Ref: ST-EA-CP-G13004