CAS 57808-65-8

Closantel

Descrizione:

Closantel è un agente antihelmintico utilizzato principalmente in medicina veterinaria per il trattamento delle infezioni parassitarie nel bestiame, in particolare nelle pecore e nel bestiame bovino. Appartiene alla classe di composti noti come salicilanilidi ed è efficace contro una gamma di nematodi e alcuni cestodi. Closantel mostra un ampio spettro di attività, in particolare contro i vermi intestinali e i vermi polmonari. Il composto è caratterizzato dalla sua natura lipofila, che ne migliora l'assorbimento e la distribuzione nel corpo. Agisce interrompendo il metabolismo energetico dei parassiti, portando alla loro paralisi e morte finale. Closantel viene tipicamente somministrato per via orale o tramite iniezione, e la sua farmacocinetica consente un'efficacia prolungata, rendendolo adatto per l'uso nella gestione del bestiame. I profili di sicurezza indicano che ha una bassa tossicità per i mammiferi, ma è necessario prestare attenzione al suo uso negli animali da produzione alimentare, poiché sono necessari periodi di sospensione per garantire che i residui non entrino nella catena alimentare. In generale, Closantel è uno strumento prezioso nella parassitologia veterinaria, contribuendo alla salute e alla produttività del bestiame.

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

InChI: InChI=1/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)

InChI key: InChIKey=JMPFSEBWVLAJKM-UHFFFAOYSA-N

SMILES: C(C#N)(C1=C(Cl)C=C(NC(=O)C2=C(O)C(I)=CC(I)=C2)C(C)=C1)C3=CC=C(Cl)C=C3

Sinonimi:

• 5'-Chloro-4'-(4-Chloro-Alpha-Cyanobenzyl)-3,5-Diiodo-2'-Methylsalicylanilide
• 5-Diiodo-Y-
• Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-
• Benzamide,N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydrox
• Closantel Base
• Clozantin
• Faskoverm
• Iodobenzamide
• N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydroxy-3,5-Di
• N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
• N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
• NSC 335306
• S 4105
• Seponver
• Zycloz
• Closantel
• CLOSANTEL(PATENT)
• N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide
• n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid
• N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE
• 5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide
• Closantelfreebase
• N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
• N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)
• N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE

Closantel

CAS: 57808-65-8

Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Purezza: 98.52% - 99.86%

Colore e forma: White To Yellowish Powder

Peso molecolare: 663.07

Ref: TM-T0237

Closantel

CAS: 57808-65-8

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 663.0737

Ref: IN-DA003602

Closantel

CAS: 57808-65-8

Closantel

Purezza: ≥98%

Peso molecolare: 663.07g/mol

Ref: 54-BUP14872

N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-Diiodobenzamide

CAS: 57808-65-8

N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-Diiodobenzamide

Purezza: 99+%

Peso molecolare: 663.07g/mol

Ref: 54-OR1030057

Closantel

CAS: 57808-65-8

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 663.07

Ref: 4Z-C-147012

Closantel 100 µg/mL in Acetonitrile

CAS: 57808-65-8

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Colore e forma: Single Solution

Peso molecolare: 663.07

Ref: 04-A11691500AL-100

Closantel 1000 µg/mL in Acetonitrile

Prodotto controllato

CAS: 57808-65-8

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Colore e forma: Single Solution

Peso molecolare: 663.07

Ref: 04-A11691500AL-1000

Closantel

Prodotto controllato

CAS: 57808-65-8

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Colore e forma: Neat

Peso molecolare: 663.07

Ref: 04-C11691500

Closantel

CAS: 57808-65-8

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Purezza: >98.0%(HPLC)(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 663.07

Ref: 3B-C3930

Closantel-(Benzoyl ring-13C6)

CAS: 57808-65-8

Formula: C₁₆₁₃C₆H₁₄Cl₂I₂N₂O₂

Peso molecolare: 669.03

Ref: 4Z-C-147011

Closantel

Prodotto controllato

CAS: 57808-65-8

Applications Closantel is potentially useful for studying P-glycoprotein interactions in vitro.Closantel was used in preparation of Closantel-derived bacterial two-component system inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hlasta, D., et al.: Bioorg. Med. Chem. Lett., 8, 1923 (1998);

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Colore e forma: Neat

Peso molecolare: 663.07

Ref: TR-C587393

Closantel

CAS: 57808-65-8

Closantel is a drug that is used to treat worm infections. Closantel binds to the enzyme target and inhibits its function, leading to cell death. Closantel has been shown to be effective against resistant mutants in wastewater treatment, as well as in animal studies. The enzyme inhibitor activity of closantel can be measured by electrochemical impedance spectroscopy (EIS) and fluorescence detection. It also shows protein binding properties with anthelmintic drugs. This drug has been shown to have no significant toxicity for humans at therapeutic doses, and is not detectable in human serum or urine samples when taken orally. It has been detected in human serum after intravenous administration, but this route of administration should be avoided due to the risk of serious adverse effects.

Formula: C₂₂H₁₄Cl₂I₂N₂O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 663.07 g/mol

Ref: 3D-FC31089

N-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

CAS: 57808-65-8

Purezza: 98%

Peso molecolare: 663.07

Ref: 10-F079437