CAS 57918-22-6

(8S,10S)-8-Acetil-7,8,9,10-tetraidro-6,8,11-triidrossi-1-metossi-10-[[2,3,6-trideossi-3-[(2,2,2-trifluoroacetil)ammino]-α-L-arabino-esopiranosil]ossi]-5,12-naftacenodione

Descrizione:

La sostanza chimica con il nome "(8S,10S)-8-Acetil-7,8,9,10-tetraidro-6,8,11-triidrossi-1-metossi-10-[[2,3,6-trideossi-3-[(2,2,2-trifluoroacetil)ammino]-α-L-arabino-esopiranosil]ossi]-5,12-naftacenodione" e numero CAS "57918-22-6" è un composto organico complesso caratterizzato dalla sua intricatissima struttura molecolare, che include più gruppi funzionali come acetile, idrossile, metossile e un moiety glicosidico. Questo composto presenta un nucleo di naftacenedione, che è indicativo della sua potenziale attività biologica, possibilmente correlata alle sue interazioni con vari bersagli biologici. La presenza di trifluoroacetile e zuccheri trideossici suggerisce che potrebbe presentare proprietà farmacologiche uniche, influenzando potenzialmente la sua solubilità, stabilità e reattività. La stereochimica indicata dalla configurazione (8S,10S) implica disposizioni spaziali specifiche che possono influenzare significativamente le interazioni biologiche e l'efficacia del composto. In generale, questa sostanza potrebbe essere di interesse nella chimica medicinale e nella farmacologia, giustificando ulteriori indagini sulle sue potenziali applicazioni e meccanismi d'azione.

Formula: C₂₉H₂₈F₃NO₁₁

InChI: InChI=1S/C29H28F3NO11/c1-10-22(35)14(33-27(40)29(30,31)32)7-17(43-10)44-16-9-28(41,11(2)34)8-13-19(16)26(39)21-20(24(13)37)23(36)12-5-4-6-15(42-3)18(12)25(21)38/h4-6,10,14,16-17,22,35,37,39,41H,7-9H2,1-3H3,(H,33,40)/t10-,14-,16-,17-,22-,28-/m0/s1

InChI key: InChIKey=VOASREXNXKOKBP-VMPUWYRSSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](NC(C(F)(F)F)=O)[C@@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

Sinonimi:

• (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-5,12-naphthacenedione
• (8S-cis)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-arabino-hexopyranosyl)oxy)naphthacene-5,12-dione
• 3-Acetyl-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1,2,3,4,6,11-Hexahydrotetracen-1-Yl 2,3,6-Trideoxy-3-[(Trifluoroacetyl)Amino]Hexopyranoside
• 4′-epi-N-Trifluoroacetyldaunorubicin
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-, (8S-cis)-
• NSC 176325
• (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-arabino-hexopyranosyl]oxy]-5,12-naphthacenedione
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-arabino-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-arabino-hexopyranosyl]oxy]-, (8S,10S)-

Epirubicin Impurity 7

CAS: 57918-22-6

Formula: C₂₉H₂₈F₃NO₁₁

Peso molecolare: 623.53

Ref: 4Z-E-144011

4'-epi-N-Trifluoroacetyldaunorubicin

Prodotto controllato

CAS: 57918-22-6

Applications 4'-epi-N-Trifluoroacetyldaunorubicin is an intermediate used in the synthesis of 4’-epi-Daunorubicin (D194490), which is a Daunorubicin (D194500) impurity. Daunomycin analog antitumor.
References Cassinelli, G., et al.: J. Antib., 38, 856 (1985), Arcamone, F., et al.: J. Med. Chem.,18, 703 (1975),

Formula: C₂₉H₂₈F₃NO₁₁

Colore e forma: Neat

Peso molecolare: 623.528

Ref: TR-T786980

4-Epi-N-trifluoroacetyldaunorubicin

CAS: 57918-22-6

4-Epi-N-trifluoroacetyldaunorubicin is an analog of the anticancer drug daunorubicin that has shown potent antitumor activity in Chinese hamster ovary (CHO) cells. It is a kinase inhibitor that targets multiple kinases involved in cancer cell proliferation and survival. This drug has been shown to induce apoptosis in cancer cells by inhibiting protein synthesis and DNA replication. 4-Epi-N-trifluoroacetyldaunorubicin has also been found to be effective against tumors that are resistant to other chemotherapy drugs, making it a promising candidate for cancer treatment. In addition, this compound has been studied as a potential therapy for polycystic kidney disease, as it has been shown to reduce urine volume and improve renal function when used with the drug tolvaptan.

Formula: C₂₉H₂₈F₃NO₁₁

Purezza: Min. 95%

Peso molecolare: 623.5 g/mol

Ref: 3D-HCA91822