CAS 57982-77-1

Buserelina

Descrizione:

Buserelina è un analogo sintetico di decapeptide dell'ormone di rilascio delle gonadotropine (GnRH), utilizzato principalmente in applicazioni mediche relative alla regolazione ormonale. Funziona come un potente agonista dei recettori della GnRH, portando alla stimolazione della ghiandola pituitaria e al successivo rilascio dell'ormone luteinizzante (LH) e dell'ormone follicolo-stimolante (FSH). Questa azione può essere utilizzata in vari contesti terapeutici, incluso il trattamento di tumori sensibili agli ormoni, come il cancro alla prostata, e nelle tecnologie di riproduzione assistita. Buserelina è caratterizzato dalla sua capacità di downregolare i recettori della GnRH con somministrazione continua, risultando in livelli ridotti di ormoni sessuali. La sostanza è tipicamente somministrata per iniezione e ha una emivita relativamente breve, richiedendo regimi di dosaggio accurati. La sua struttura chimica include una sequenza specifica di amminoacidi che conferisce la sua attività biologica, ed è classificata come un ormone peptidico. Come per qualsiasi farmaco, gli effetti collaterali potenziali possono includere squilibri ormonali e reazioni nel sito di iniezione, evidenziando l'importanza della supervisione medica durante il suo utilizzo.

Formula: C₆₀H₈₆N₁₆O₁₃

InChI: InChI=1/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1

Sinonimi:

• 5-oxoprolylhistidyltryptophylseryltyrosyl-O-tert-butylserylleucyl-N~5~-(diaminomethylidene)ornithyl-N-ethylprolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-N-ethyl-L-prolinamide
• [D-Ser(tert-butyl)6,des-Gly-NH210]-LH-RH ethylamide
• [D-Ser6(t-Bu),de-Gly10-NH2]-LH-RH ethylamide
• 1-9-(D-Ser(t-butyl))6-LH-releasing hormone ethylamide
• 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-
• Buserelina
• Busereline
• Etilamide
• Hoe 766
• Hoe 766A
• Ici 123215
• Luteinizing hormone-releasing factor (pig), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-
• Receptal

(Des-Gly¹⁰,D-Ser(tBu)⁶,Pro-NHEt⁹)-LHRH

CAS: 57982-77-1

Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH. CAS Number (buserelin acetate): 68630-75-1.

Formula: C₆₀H₈₆N₁₆O₁₃

Purezza: 98.0%

Colore e forma: White

Peso molecolare: 1239.44

Ref: 01-4028150

Buserelin-d7 Tritrifluoroacetate

CAS: 57982-77-1

Formula: C₆₀H₇₉D₇N₁₆O₁₃·3C₂HF₃O₂

Peso molecolare: 1246.49 3*114.02

Ref: 4Z-PB-102

Buserelin

CAS: 57982-77-1

Formula: C₆₀H₈₆N₁₆O₁₃

Purezza: ≥ 97.0%

Colore e forma: White powder

Peso molecolare: 1239.42

Ref: 7W-GP3966

Buserelin Ditrifluoroacetate

CAS: 57982-77-1

Formula: C₆₀H₈₆N₁₆O₁₃·2C₂HF₃O₂

Colore e forma: Off-White Solid

Peso molecolare: 1239.45 2*114.02

Ref: 4Z-PB-101

Buserelin Acetate

CAS: 57982-77-1

Formula: C₆₀H₈₆N₁₆O₁₃

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 1239.43

Ref: BP-BPPG012

Buserelin

CAS: 57982-77-1

Buserelin

Colore e forma: White Lyophilised Powder

Peso molecolare: 1,239.42g/mol

Ref: 54-BITH3005

(Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt

CAS: 57982-77-1

This drug is used for the treatment of endometriosis. It belongs to the class of drugs called GnRH analogues and acts by binding to receptors in the pituitary gland that control hormone production. The receptor is then activated, which leads to a decrease in the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This results in a reduction in estrogen levels, which decreases uterine growth and thickening. The drug is used for short periods of time, usually 3-6 months, before taking a break for 1-2 months.
Estradiol benzoate is an estrogen medication that can be taken orally or via injection. It has been shown to have more beneficial effects on endometriosis than estradiol because it can improve symptoms such as pain and heavy menstrual bleeding. Estradiol benzoate may also be effective at treating autoimmune diseases because it has anti-inflammatory properties.
The mechanism of

Formula: C₆₀H₈₆N₁₆O₁₃

Purezza: Min. 95%

Peso molecolare: 1,239.42 g/mol

Ref: 3D-FD109219