CAS 58-14-0

2,4-Pirimidinediamina, 5-(4-clorofenil)-6-etil-

Descrizione:

2,4-Pirimidinediamina, 5-(4-clorofenil)-6-etil-, comunemente noto come Etile 5-(4-clorofenil)-2,4-pirimidinediamina, è un composto organico caratterizzato dalla sua struttura ad anello di pirimidina, che è un eterociclo aromatico a sei membri contenente due atomi di azoto nelle posizioni 2 e 4. Questo composto presenta un gruppo etile nella posizione 6 e un gruppo para-clorofenile nella posizione 5, contribuendo alle sue uniche proprietà chimiche. È tipicamente un solido a temperatura ambiente e può mostrare una solubilità moderata in solventi polari. La presenza di gruppi amino nella struttura consente una reattività potenziale, inclusi legami idrogeno e sostituzione nucleofila. Questo composto è di interesse in vari campi, tra cui farmaceutici e agrochimici, a causa della sua potenziale attività biologica. I dati di sicurezza indicano che deve essere maneggiato con cura, poiché può comportare rischi per la salute in caso di esposizione. I protocolli adeguati di stoccaggio e manipolazione sono essenziali per garantire sicurezza e stabilità.

Formula: C₁₂H₁₃ClN₄

InChI: InChI=1/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

InChI key: InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N

SMILES: C(C)C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2

Sinonimi:

• 2, 4-Diamino-5-(4'-chlorophenyl)-6-ethylpyrimidine
• 2, 4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
• 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
• 2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine
• 4753 R.P.
• 5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
• 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
• 5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
• Bw 50-63
• Chloridin
• Chloridine
• Darachlor
• Darapram
• Daraprim
• Daraprime
• Diaminopyritamin
• Erbaprelina
• Khloridin
• Malacid
• Malocid
• Malocide
• Nsc 3061
• Pirimecidan
• Pirimetamin
• Pirimetamina
• Pyrimethamin
• Pyrimethamine
• Pyrimethamine Base
• Pyrimidine, 2,4-diamino-5-(p-chlorophenyl)-6-ethyl-
• Rp 4753
• Tindurin
• Tinduring
• Wr 2978
• 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
• 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-
• 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diyldiamine
• 5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine
• 2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-
• 4753r.p.
• 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
• bw50-63

Pyrimethamine

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 248.71

Ref: 3B-P2037

Pyrimethamine

CAS: 58-14-0

Colore e forma: Neat

Ref: 61-FOR1630.00

PYRIMETHAMINE CRS

CAS: 58-14-0

PYRIMETHAMINE CRS

Formula: C₁₂H₁₃ClN₄

Colore e forma: Crystalline Powder. White. Colourless Crystals. Powder.

Peso molecolare: 248.7114

Ref: 41-P4200000

PYRIMETHAMINE RS

CAS: 58-14-0

PYRIMETHAMINE RS

Formula: C₁₂H₁₃ClN₄

Peso molecolare: 248.7114

Ref: 41-ICRS47051

Pyrimethamine

CAS: 58-14-0

Pyrimethamine

Formula: C₁₂H₁₃CIN₄

Purezza: 99.5%

Colore e forma: White

Peso molecolare: 352.01849

Ref: 47-1227

Pyrimethamine

CAS: 58-14-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₁₂H₁₃ClN₄

Colore e forma: White Powder

Peso molecolare: 248.08287

Ref: 45-1589007

2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 248.7114

Ref: IN-DA00IKHO

Pyrimethamine

CAS: 58-14-0

Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.

Formula: C₁₂H₁₃ClN₄

Purezza: 99.67%

Colore e forma: Crystals

Peso molecolare: 248.71

Ref: TM-T0849

Pyrimethamine

CAS: 58-14-0

Pyrimethamine

Purezza: ≥98%

Peso molecolare: 248.71g/mol

Ref: 54-BUP14770

Pyrimethamine

CAS: 58-14-0

Pyrimethamine

Purezza: 98%

Peso molecolare: 248.71g/mol

Ref: 54-OR1029094

Pyrimethamine-d3-15N3

CAS: 58-14-0

Formula: N₃C₁₂H₁₀D₃ClN

Colore e forma: Off-White Solid

Peso molecolare: 254.71

Ref: 4Z-P-154004

Pyrimethamine

Prodotto controllato

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Colore e forma: Neat

Peso molecolare: 248.71

Ref: 86-MM1630.00

Pyrimethamine

Prodotto controllato

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Colore e forma: Neat

Peso molecolare: 248.71

Ref: 04-C16658000

Pyrimethamine

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Peso molecolare: 248.72

Ref: 4Z-P-154001

Pyrimethamine-d5

CAS: 58-14-0

Formula: C₁₂H₈D₅ClN₄

Peso molecolare: 253.74

Ref: 4Z-P-154003

Pyrimethamine

Prodotto controllato

CAS: 58-14-0

Applications Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.
References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),

Formula: C₁₂H₁₃ClN₄

Colore e forma: White To Off-White

Peso molecolare: 248.71

Ref: TR-P997240

Pyrimethamine

CAS: 58-14-0

Pyrimethamine is an antimalarial agent that has been used in the treatment of various infectious diseases. Pyrimethamine is a folic acid antagonist which inhibits the synthesis of DNA and RNA by inhibiting the enzyme dihydrofolate reductase. The drug binds to sulfadiazine, a sulfa drug, which prevents its conversion to active form and thereby prevents bacterial growth. Pyrimethamine can be administered orally or intravenously. It exhibits low toxicity and is excreted in the urine as an inactive metabolite. In vitro assays have shown pyrimethamine to be effective against HIV-1 infection, but it is not active against other viruses such as herpes simplex virus and influenza virus.

Formula: C₁₂H₁₃ClN₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 248.71 g/mol

Ref: 3D-FP27346

5-(4-Chlorophenyl)-6-ethylpyrimidine-2,4-diamine

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Purezza: 95%

Colore e forma: No data available.

Peso molecolare: 248.71

Ref: 10-F211965