CAS 58-58-2

Cloridrato di puromicina

Descrizione:

Cloridrato di puromicina è un composto antibiotico derivato dal batterio *Streptomyces alboniger*. È principalmente noto per il suo ruolo di inibitore della sintesi proteica, mirando specificamente alla macchina ribosomiale delle cellule procariote ed eucariote. Il composto funziona mimando la struttura dell'aminoacil-tRNA, portando alla terminazione prematura delle catene polipeptidiche durante la traduzione. Cloridrato di puromicina è tipicamente presentato come una polvere cristallina bianca o bianco sporco, solubile in acqua e in vari solventi organici. La sua formula molecolare include elementi come carbonio, idrogeno, azoto e ossigeno, contribuendo alla sua attività biologica. In ambienti di laboratorio, la puromicina è ampiamente utilizzata in biologia molecolare per selezionare cellule geneticamente modificate, poiché può eliminare efficacemente le cellule non resistenti. Tuttavia, a causa dei suoi potenti effetti, la manipolazione richiede cautela e devono essere osservate le misure di sicurezza appropriate. In generale, Cloridrato di puromicina serve come uno strumento prezioso nella ricerca, in particolare negli studi relativi all'espressione genica e alla sintesi proteica.

Formula: C₂₂H₂₉N₇O₅·2ClH

InChI: InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1

InChI key: InChIKey=MKSVFGKWZLUTTO-FZFAUISWSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N(C)C)N=CN3)O[C@H](CO)[C@H]1NC([C@H](CC4=CC=C(OC)C=C4)N)=O.Cl

Sinonimi:

• Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, hydrochloride (1:2)
• Adenosine, 3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-, dihydrochloride, L-
• Adenosine, 3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride, (S)-
• Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride
• CL 16,536

Puromycin dihydrochloride, 98%

CAS: 58-58-2

Puromycin dihydrochloride, 58-58-2, also known as stylomycin hydrochloride, is an aminoglycoside antibiotic which acts by inhibiting protein synthesis. Learn more.

Formula: C₂₂H₃₁Cl₂N₇O₅

Purezza: 98%

Colore e forma: White to pale cream, Powder

Peso molecolare: 544.43

Ref: 02-J61278

Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered

CAS: 58-58-2

Puromycin, 58-58-2, is an aminoglycoside antibiotic produced by Streptomyces alboniger which acts by inhibiting protein synthesis. Learn more at Thermo Fisher Scientific.

Formula: C₂₂H₂₉N₇O₅

Colore e forma: Clear colorless to pale cream, Liquid

Peso molecolare: 471.52

Ref: 02-J67236

Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride

CAS: 58-58-2

Formula: C₂₂H₃₁Cl₂N₇O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 544.4314

Ref: IN-DA00IABE

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride

Formula: C₂₂H₂₉N₇O₅·2ClH

Purezza: By hplc: 98.48% (Typical Value in Batch COA)

Colore e forma: off-white powder

Peso molecolare: 544.43g/mol

Ref: 54-BIP3340

Puromycin dihydrochloride (animal free)

CAS: 58-58-2

Puromycin dihydrochloride (animal free)

Formula: C₂₂H₂₉N₇O₅·2ClH

Purezza: By hplc: 99.07% (Typical Value in Batch COA)

Colore e forma: slightly pink powder

Peso molecolare: 544.43g/mol

Ref: 54-BIP4033

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride

Purezza: ≥98%

Peso molecolare: 544.44g/mol

Ref: 54-BUP13663

Puromycin DiHCl

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Peso molecolare: 471.52 2 36.46

Ref: 4Z-P-301001

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride, from Streptomyces alboniger, blocks protein synthesis, acting as an antineoplastic and antitrypanosomal agent.

Formula: C₂₂H₃₁Cl₂N₇O₅

Purezza: 98.65% - 99.89%

Colore e forma: Physical Description White Powder (Ntp 1992)

Peso molecolare: 544.44

Ref: TM-T2219

Puromycin dihydrochloride

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 544.44

Ref: 7W-GA1940

Puromycin Dihydrochloride

Prodotto controllato

CAS: 58-58-2

Applications Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

Formula: C₂₂H₂₉N₇O₅·2ClH

Colore e forma: Neat

Peso molecolare: 544.43

Ref: TR-P840320

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin is active against both prokaryotic and eukaryotic cells. Puromycin resistance gene (pac) is a common choice for the selection of mammalian cells since its first application in 1988, especially for therapeutic proteins in mammalian cells where it was used to produce high levels of protein of interest. Puromycin can also be used as a selection marker for Archea.

Formula: C₂₂H₃₁Cl₂N₇O₅

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 544.44 g/mol

Ref: 3D-NP09203

Puromycin Dihydrochloride (PRM), 98%

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Purezza: min. 98%

Colore e forma: White to pale yellow, Powder

Peso molecolare: 544.44

Ref: SR-93909

Puromycin Dihydrochloride (PRM) for cell culture, Endotoxin (BET) 10EU/mg

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Purezza: min. 98%

Colore e forma: White to pale yellow, Powder

Peso molecolare: 544.44

Ref: SR-82361

Puromycin dihydrochloride

CAS: 58-58-2

M02245 - Puromycin dihydrochloride

Formula: C₂₂H₃₁Cl₂N₇O₅

Purezza: 98%

Colore e forma: Solid, Powder

Peso molecolare: 544.43

Ref: 10-M02245

Puromycin-D3 Dihydrochloride

Prodotto controllato

CAS: 58-58-2

Applications Puromycin-D3 Dihydrochloride is a labelled analogue of Puromycin Dihydrochloride (P840320), an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

Formula: C₂₂H₂₆D₃N₇O₅•2(HCl)

Colore e forma: Neat

Peso molecolare: 474.53 + 2(36.46)

Ref: TR-P840322