CAS 58066-85-6

Miltefosina

Descrizione:

Miltefosina è un composto organico principalmente riconosciuto per il suo utilizzo come farmaco antiparassitario, in particolare nel trattamento della leishmaniosi. È classificato come un derivato dei fosfolipidi ed è caratterizzato dalla sua natura anfifilica, che gli consente di interagire con ambienti sia idrofili che idrofobici. Miltefosina ha una formula molecolare che include carbonio, idrogeno, azoto, ossigeno e fosforo, contribuendo alla sua struttura complessa. La sostanza è tipicamente somministrata per via orale ed è notevole per la sua capacità di interrompere le membrane cellulari e inibire la crescita dei parassiti. Il suo meccanismo d'azione implica l'interferenza con il metabolismo lipidico e l'apoptosi negli organismi bersaglio. Miltefosina è anche associato a una serie di effetti collaterali, tra cui disturbi gastrointestinali e potenziali effetti teratogeni, richiedendo cautela nel suo utilizzo, in particolare in individui in gravidanza. Inoltre, è stato studiato per potenziali applicazioni oltre la leishmaniosi, comprese le sue proprietà antivirali. In generale, Miltefosina rappresenta un significativo progresso nella gestione farmacologica di alcune infezioni parassitarie.

Formula: C₂₁H₄₆NO₄P

InChI: InChI=1/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3

InChI key: InChIKey=PQLXHQMOHUQAKB-UHFFFAOYSA-N

SMILES: O(P(OCC[N+](C)(C)C)(=O)[O-])CCCCCCCCCCCCCCCC

Sinonimi:

• 1-n-Hexadecylphosphorylcholine
• 2-(((Hexadecyloxy)Hydroxyphosphinyl)Oxy)-N,N,N-Trimethyl-Ethanaminiuhydrox
• 2-(((Hexadecyloxy)Hydroxyphosphinyl)Oxy)-N,N,N-Trimethylethanaminiumhydroxid
• Choline Hexadecyl Phosphate
• Choline phosphate, hexadecyl ester, hydroxide, inner salt
• Cholinephosphate,Hexadecylester,Hydroxide,Innersalt
• D 18506
• Ethanaminium, 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
• Fos-choline 16
• Hexadecyl 2-(Trimethylammonio)Ethyl Phosphate
• Hexadecylphosphorylcholine
• Impavido
• Miltefos
• Miltefosine
• Miltex
• NSC 605583
• n-Hexadecylphosphocholine
• n-Hexadecylphosphorylcholine
• Hexadecylphosphocholine
• HPC
• C16 : O
• HEXADECYL PHOSPHORYLCHOLINE
• Miltefosin
• 1-HEXADECYLPHOSPHOCHOLINE
• mil
• d18506
• HEPC
• 1-HEXADECYLPHOSPHORYLCHOLINE
• C16:0
• Hexadecyl 2-(trimethylamino)ethyl phosphate
• N-HEXADECYL-PHOSPHOCHOLINE

Miltefosine

CAS: 58066-85-6

Formula: C₂₁H₄₆NO₄P

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 407.58

Ref: 3B-M2445

Miltefosine

CAS: 58066-85-6

Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.

Formula: C₂₁H₄₆NO₄P

Purezza: 98% - 99.87%

Colore e forma: White To Off-White Powder

Peso molecolare: 407.57

Ref: TM-T0033

Miltefosine

CAS: 58066-85-6

Formula: C₂₁H₄₆NO₄P

Colore e forma: White To Off-White Solid

Peso molecolare: 407.58

Ref: 4Z-M-791

Miltefosine

CAS: 58066-85-6

Miltefosine

Purezza: ≥98%

Peso molecolare: 407.57g/mol

Ref: 54-BUP15995

Miltefosine

CAS: 58066-85-6

Formula: C₂₁H₄₆NO₄P

Purezza: ≥ 98.0% (anhydrous basis)

Colore e forma: White or almost white powder

Peso molecolare: 407.57

Ref: 7W-GL2721

Hexadecylphosphocholine

CAS: 58066-85-6

Hexadecylphosphocholine

Formula: H₂

Colore e forma: white powder

Peso molecolare: 407.57g/mol

Ref: 54-BIB6120

Miltefosine-d9

CAS: 58066-85-6

Formula: C₂₁H₃₇D₉NO₄P

Peso molecolare: 416.63

Ref: 4Z-M-792

Miltefosine

Prodotto controllato

CAS: 58066-85-6

Applications A phospholipid drug with antineoplastic and antiprotozoal/antifungal properties, also acts as an Akt inhibitor, and under investigation as a potential therapy against HIV infection.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chugh, P., et al al.: Retrovirology, 5, 11 (2008), Dorio, T., et al.: Antimicrob. Agents Chemother., 52, 2855 (2008),

Formula: C₂₁H₄₆NO₄P

Colore e forma: Neat

Peso molecolare: 407.57

Ref: TR-M344460

1-Hexadecylphosphorylcholine

CAS: 58066-85-6

Treatment for leishmaniasis

Formula: C₂₁H₄₆NO₄P

Purezza: Min 98%

Colore e forma: White Powder

Peso molecolare: 407.57 g/mol

Ref: 3D-FH10347

Hexadecylphosphocholine

CAS: 58066-85-6

Hexadecylphosphocholine, better known as miltefosine, belongs to the group of phospholipids. The long alkyl chain and a polar group of a molecule proved to be essential for antitumor activity, especially to cure breast cancer cells. The apoptotic process takes place in the plasma membrane, where molecules are inserted and then influence signaling pathways. Moreover, during preclinical studies hexadecylphosphocholine (He-PC) found to be highly effective in inhibiting the growth of chemically induced rat mammary carcinomas, and even a high percentage of the tumors regressed completely. The He-PC has many more applications such as antifungal agent, antiprotozoal drug, protein kinase inhibitor or immunomodulator. Even though miltefosine was originally developed in the 1980s as an anti-cancer agent, new studies have demonstrated activity against Leishmania parasites and neoplastic cells, and due to broad spectrum of antimicrobial effects, it is recommended as a first line treatment for free-living amebae infections.

Formula: C₂₁H₄₆NO₄P

Peso molecolare: 407.57 g/mol

Ref: 3D-M-7200

1-Hexadecylphosphocholine

CAS: 58066-85-6

M01856 - 1-Hexadecylphosphocholine

Formula: C₂₁H₄₆NO₄P

Purezza: >99%

Colore e forma: Solid

Peso molecolare: 407.576

Ref: 10-M01856

Miltefosine-d9

Prodotto controllato

CAS: 58066-85-6

Formula: C₂₁H₃₇D₉NO₄P

Colore e forma: Neat

Peso molecolare: 662.796

Ref: TR-M344463