CAS 58479-68-8

Platicodina D

Descrizione:

Platicodina D è una saponina triterpenoide derivata principalmente dalla radice di Platycodon grandiflorus, una pianta comunemente utilizzata nella medicina tradizionale, in particolare nell'Asia orientale. È nota per le sue varie attività biologiche, comprese le proprietà antinfiammatorie, immunomodulatrici e anticancro. La struttura chimica di Platicodina D presenta uno scheletro di tipo dammarano, che contribuisce alla sua bioattività. È tipicamente caratterizzata dalla sua solubilità in acqua e solventi organici, sebbene la sua solubilità possa variare a seconda del solvente utilizzato. Platicodina D è stato oggetto di numerosi studi che indagano i suoi effetti farmacologici, incluso il suo potenziale di migliorare la salute respiratoria e il suo ruolo nella modulazione delle risposte immunitarie. Inoltre, mostra effetti citotossici contro alcune linee cellulari tumorali, rendendolo un composto di interesse nella ricerca sul cancro. Come molti prodotti naturali, i processi di estrazione e purificazione possono influenzare la sua efficacia e biodisponibilità, evidenziando l'importanza di tecniche analitiche adeguate nello studio delle sue proprietà e applicazioni.

Formula: C₅₇H₉₂O₂₈

InChI: InChI=1S/C57H92O28/c1-23-40(81-45-39(72)41(28(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)27(63)17-77-48(42)85-50(74)57-12-11-51(2,3)13-25(57)24-7-8-30-52(4)14-26(62)44(84-47-37(70)35(68)34(67)29(16-58)80-47)55(19-59,20-60)31(52)9-10-53(30,5)54(24,6)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25-,26-,27-,28+,29+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48-,49-,52+,53+,54+,56+,57+/m0/s1

InChI key: InChIKey=CYBWUNOAQPMRBA-NDTOZIJESA-N

SMILES: C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O[C@H]4[C@H](O)[C@](CO)(O)CO4)[C@H](O)CO3)[C@H](C)O2)[C@@H](O)[C@@H](O)CO1)(=O)[C@]56[C@](C=7[C@@](C)(C[C@H]5O)[C@@]8(C)[C@](CC7)([C@]9(C)[C@@](CC8)(C(CO)(CO)[C@@H](O[C@@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%10O)[C@@H](O)C9)[H])[H])(CC(C)(C)CC6)[H]

Sinonimi:

• (1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
• 2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-
• 3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]-beta-D-xylopyranosyl-(1->4)-6-deoxy-alpha-L-mannopyranosyl-(1->2)-1-O-[(2beta,3beta,16alpha)-3-(beta-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-28-oxoolean-12-en-28-yl]-alpha-L-arabinopyranose
• Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-
• Olean-12-en-28-oic acid, 3-(β-<span class="text-smallcaps">D</smallcap>-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-<smallcap>D</smallcap>-apio-β-<smallcap>D</smallcap>-furanosyl-(1→3)-O-β-<smallcap>D</smallcap>-xylopyranosyl-(1→4)-O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→2)-α-<smallcap>L</span>-arabinopyranosyl ester, (2β,3β,16α)-
• beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-
• beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-
• (1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
• Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-
• 2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-
• Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,16α)-

PLATYCODIN D CRS

CAS: 58479-68-8

PLATYCODIN D CRS

Ref: 41-Y0001946

Platycodin D

CAS: 58479-68-8

Formula: C₅₇H₉₂O₂₈

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 1225.3236

Ref: IN-DA00EBH4

Platycodin D

CAS: 58479-68-8

Formula: C₅₇H₉₂O₂₈

Peso molecolare: 1225.34

Ref: 7W-GY7597

Platycodin D

CAS: 58479-68-8

Platycodon D (PD) and D3 (PD3) isolated from Platycodon grandiflorum has been previously reported to show anti-inflammatory activities in rats, PD may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, suggest a dichotomous regulation of these important proinflammatory mediators by PD and PD3.

Formula: C₅₇H₉₂O₂₈

Purezza: 95%~99%

Colore e forma: White powder

Peso molecolare: 1225.34

Ref: BP-BP1111

Platycodin D

CAS: 58479-68-8

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.

Formula: C₅₇H₉₂O₂₈

Purezza: 99.2% - 99.65%

Colore e forma: Solid

Peso molecolare: 1225.32

Ref: TM-T3889

Platycodin d

CAS: 58479-68-8

Natural glycoside

Formula: C₅₇H₉₂O₂₈

Purezza: ≥ 98.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 1225.34

Ref: 5G-80518

Platycodin D

Prodotto controllato

CAS: 58479-68-8

Applications Platycodin D is a known inhibitor of the proliferation of human gastric cancer cells as well as inducing apoptosis. It also causes anti-atherosclerotic.
References Wu, J. et al.: Biol. Pharm. Bull. 35, 1216 (2012); Chun, J. et al.: J. Cell. Biochem., 114, 456 (2013);

Formula: C₅₇H₉₂O₂₈

Colore e forma: Neat

Peso molecolare: 1225.32

Ref: TR-P578200

Platycodin D

CAS: 58479-68-8

Platycodin D is a natural product that belongs to the class of platycodins. It is a polysaccharide with anti-inflammatory properties and has been shown to suppress inflammation, oxidative injury, and improve mitochondrial function in vitro. Platycodin D also inhibits Toll-like receptor (TLR) signaling pathways that are activated by extracellular bacteria or their products. Platycodin D binds to dsDNA and inhibits DNA binding proteins such as dextran sulfate. This interaction prevents the induction of the inflammatory response. The effects of platycodin D have been demonstrated in an experimental model involving mice. In vivo studies on rats have shown that this compound has an anti-inflammatory effect and reduces oxidative injury.

Formula: C₅₇H₉₂O₂₈

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 1,225.32 g/mol

Ref: 3D-FP73789