CAS 58970-76-6

Bestatina

Descrizione:

Bestatina è un composto chimico noto per il suo ruolo come potente inibitore delle aminopeptidasi, in particolare dell'aminopeptidasi N. È classificato come un dipeptide, composto dagli aminoacidi L-fenilalanina e L-leucina. Bestatina presenta una struttura unica che gli consente di legarsi efficacemente al sito attivo delle aminopeptidasi, inibendo così la loro attività enzimatica. Questa inibizione ha implicazioni in vari processi biologici, inclusa la modulazione della risposta immunitaria e il trattamento del cancro. Bestatina è anche noto per il suo potenziale utilizzo nel migliorare l'efficacia di alcuni agenti chemioterapici. Il composto viene tipicamente somministrato in un contesto farmaceutico e il suo profilo di sicurezza è stato valutato in studi clinici. Come molti composti bioattivi, la farmacocinetica e il metabolismo di Bestatina sono importanti per comprendere le sue applicazioni terapeutiche e i potenziali effetti collaterali. In generale, Bestatina rappresenta un interesse significativo nella chimica medicinale grazie alle sue proprietà di inibizione enzimatica e ai potenziali benefici terapeutici.

Formula: C₁₆H₂₄N₂O₄

InChI: InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1

InChI key: InChIKey=VGGGPCQERPFHOB-RDBSUJKOSA-N

SMILES: C([C@H]([C@@H](C(N[C@@H](CC(C)C)C(O)=O)=O)O)N)C1=CC=CC=C1

Sinonimi:

• <span class="text-smallcaps">L</span>-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
• <span class="text-smallcaps">L</span>-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-
• Bestain
• Bestatin
• N-(3-amino-2-hydroxy-4-phenylbutanoyl)leucine
• N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-<span class="text-smallcaps">L</span>-leucine
• N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-D-leucine
• N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine
• N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]leucine
• NSC 265489
• Nk 421
• L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
• N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine

Bestatin

CAS: 58970-76-6

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in mul

Formula: C₁₆H₂₄N₂O₄

Colore e forma: White to pale cream, Powder

Peso molecolare: 308.38

Ref: 02-J61106

[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine

CAS: 58970-76-6

Bestatin (or ubenimex), an antibiotic of natural origin, is a specific, competitive inhibitor of many aminopeptidases, though it does not inhibit aminopeptidase A. Due to its low toxicity it has been administered to cultured cells, animals and humans. Bestatin offered by Bachem has been obtained by chemical synthesis.

Formula: C₁₆H₂₄N₂O₄

Purezza: 99.5%

Colore e forma: White Powder

Peso molecolare: 308.38

Ref: 01-4006587

(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid

CAS: 58970-76-6

Formula: C₁₆H₂₄N₂O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 308.3728

Ref: IN-DA00370Q

Bestatin (Ubenimex)

CAS: 58970-76-6

Formula: C₁₆H₂₄N₂O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 308.38

Ref: 4Z-B-119001

Bestatin

CAS: 58970-76-6

Bestatin

Purezza: ≥98%

Peso molecolare: 308.37g/mol

Ref: 54-BUP10959

N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine

CAS: 58970-76-6

Formula: C₁₆H₂₄N₂O₄

Purezza: ≥ 98.0%

Colore e forma: White powder

Peso molecolare: 308.37

Ref: 7W-GM3911

Ubenimex Hydrochloride [for Biochemical Research]

CAS: 58970-76-6, 65391-42-6

Formula: C₁₆H₂₄N₂O₄·HCl

Purezza: >97.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 344.84

Ref: 3B-B4000

Ubenimex

CAS: 58970-76-6

Formula: C₁₆H₂₄N₂O₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 308.38

Ref: 3B-U0111

Bestatin-d5 (Ubenimex-d5)

CAS: 58970-76-6

Formula: C₁₆H₁₉N₂O₄D₅

Peso molecolare: 313.41

Ref: 4Z-B-119002

Bestatin free base

CAS: 58970-76-6

Bestatin free base

Formula: C₁₆H₂₄N₂O₄

Purezza: By hplc: >98% by area (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 308.37g/mol

Ref: 54-BIMI2138

Bestatin

CAS: 58970-76-6

Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.

Formula: C₁₆H₂₄N₂O₄

Purezza: 98% - 99.63%

Colore e forma: White Crystalline Powder

Peso molecolare: 308.37

Ref: TM-T1257

Ubenimex - Bio-X ™

CAS: 58970-76-6

Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.

Formula: C₁₆H₂₄N₂O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 308.37 g/mol

Ref: 3D-BU164499

Ubenimex

CAS: 58970-76-6

Aminopeptidase N (CD13) inhibitor; immunomodulator

Formula: C₁₆H₂₄N₂O₄

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 308.37 g/mol

Ref: 3D-FU65199

Ubenimex (Bestatin)

CAS: 58970-76-6

Ubenimex (Bestatin) is an enzyme inhibitor that belongs to the class of dpp-iv inhibitors. It is used as an antifungal agent and has been shown to be effective against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton mentagrophytes, and Microsporum canis. Ubenimex (Bestatin) inhibits the synthesis of protein by binding to the 30S ribosomal subunit and blocking the peptidyl transferase activity of the 50S ribosomal subunit. This drug also has a cytostatic effect on cancer cells in vitro.

Formula: C₁₆H₂₄N₂O₄

Purezza: Min. 95%

Peso molecolare: 308.37 g/mol

Ref: 3D-IBS-4093-PI

Bestatin

Prodotto controllato

CAS: 58970-76-6

Applications Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase.
References Umezawa, H., et al.: J. Antib., 29, 97 (1976); Poloz, Y., et al.: Eukaryotic Cell, 11, 545 (2012);

Formula: C₁₆H₂₄N₂O₄

Colore e forma: Neat

Peso molecolare: 308.37

Ref: TR-B319500

Bestatin-d7

Prodotto controllato

CAS: 58970-76-6

Formula: C₁₆D₇H₁₇N₂O₄

Colore e forma: Neat

Peso molecolare: 315.416

Ref: TR-B319502