CAS 59-05-2

Metotrexato

Descrizione:

Metotrexato è un potente antimetabolita e agente immunosoppressore utilizzato principalmente nel trattamento di alcuni tumori, malattie autoimmuni e gravidanze ectopiche. La sua formula chimica è C20H22N8O5S e presenta una struttura ad anello di pteridina, che è cruciale per il suo meccanismo d'azione. Metotrexato agisce inibendo l'enzima diidrofolato reduttasi, interrompendo così la sintesi dei nucleotidi e influenzando infine la replicazione del DNA e la divisione cellulare. Questo lo rende particolarmente efficace contro le cellule a rapida divisione, come quelle presenti nei tumori. Metotrexato viene somministrato in varie forme, tra cui compresse orali e soluzioni iniettabili, e la sua farmacocinetica può variare in base alla via di somministrazione. Il farmaco è noto per i suoi potenziali effetti collaterali, che possono includere disturbi gastrointestinali, tossicità epatica e soppressione del midollo osseo. A causa delle sue proprietà immunosoppressive, è essenziale un attento monitoraggio durante il trattamento per gestire gli effetti avversi e le interazioni con altri farmaci. L'uso di Metotrexato a dosi più basse per condizioni autoimmuni evidenzia la sua versatilità nelle applicazioni cliniche.

Formula: C₂₀H₂₂N₈O₅

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChI key: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N

SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Sinonimi:

• (+)-4-Amino-10-Methylfolic Acid
• (+)-Amethopterin
• (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-1
• 4-Amino-4-Deoxy-N(Sup10
• 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
• 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
• 4-Amino-N10-methylfolic acid
• 4-Amino-N10-methylpteroylglutamic acid
• 4-Amino-N¹⁰-methylfolic acid
• 4-Amino-N¹⁰-methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Amethopterin
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Methotrexate
• Amethopterine
• Antifolan
• Caditrex
• Cl 14377
• Emt 25299
• Emtexate
• Emthexate PF
• Emtrexate
• Folex
• Folex PFS
• Folitrax
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
• Jylamvo
• L-(+)-Amethopterin
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Methotrexate
• Ledertrexate
• Merex
• Metatrexan
• Methocel
• Methocip
• Methotrexat
• Methotrexat-Ebewe
• Methotrexate LPF
• Methoxtrexate
• Methylaminopterin
• Methylaminopterine
• Methylpteroylglutamate
• Methylpteroylglutamic Acid
• Metorex
• Metotrexato
• Mexate
• Mexate-AQ
• Mtx
• N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
• Nordimet
• Nsc 740
• Oncotrex
• R 9985
• Remtrex
• Rheumatrex
• Trexall
• Trilem

Methotrexate Hydrate

CAS: 133073-73-1, 59-05-2

Formula: C₂₀H₂₂N₈O₅·xH₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: Light yellow to Brown powder to crystal

Peso molecolare: 454.45 (as Anhydrous)

Ref: 3B-M1664

Methotrexate

CAS: 59-05-2

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely use

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Yellow or yellow-orange, Powder or crystalline powder

Peso molecolare: 454.45

Ref: 02-J63075

Methotrexate

CAS: 59-05-2

Colore e forma: Neat

Ref: 61-FOR0040.00

METHOTREXATE RS

CAS: 59-05-2

METHOTREXATE RS

Formula: C₂₀H₂₂N₈O₅

Peso molecolare: 454.4393

Ref: 41-ICRS0345

METHOTREXATE FOR PEAK IDENTIFICATION CRS

CAS: 59-05-2

METHOTREXATE FOR PEAK IDENTIFICATION CRS

Formula: C₂₀H₂₂N₈O₅

Peso molecolare: 454.4393

Ref: 41-Y0000602

METHOTREXATE CRS

CAS: 59-05-2

METHOTREXATE CRS

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Crystalline Powder. Yellow. Orange. Powder.

Peso molecolare: 454.4393

Ref: 41-M1000000

Methotrexate

CAS: 59-05-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Yellow Brown Orange Powder

Peso molecolare: 454.17132

Ref: 45-1414003

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 454.4393

Ref: IN-DA0039PY

Methotrexate

CAS: 59-05-2

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.

Formula: C₂₀H₂₂N₈O₅

Purezza: 96.84% - 99.91%

Colore e forma: Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna Synthesis

Peso molecolare: 454.44

Ref: TM-T1485

Methotrexate

CAS: 59-05-2

Methotrexate

Purezza: ≥95%

Peso molecolare: 454.44g/mol

Ref: 54-BUP17033

Methotrexate

CAS: 59-05-2

Methotrexate

Formula: C₂₀H₂₂N₈O₅

Purezza: By hplc: 98.13% (Typical Value in Batch COA)

Colore e forma: yellow solid

Peso molecolare: 454.43927g/mol

Ref: 54-BIM0130

Methotrexate

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Yellow Solid

Peso molecolare: 454.45

Ref: 4Z-M-701

Methotrexate 1.0 mg/ml in Dimethyl Sulfoxide

CAS: 59-05-2

Colore e forma: Single Solution

Ref: 61-AMP0040.00-29

Methotrexate

Prodotto controllato

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Neat

Peso molecolare: 454.44

Ref: 86-MM0040.00

Methotrexate

Prodotto controllato

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Neat

Peso molecolare: 454.44

Ref: 04-C15056900

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

Formula: C₅₀H₆₄N₁₄O₂₃·C₂HF₃O₂

Peso molecolare: 1229.14

Ref: 4Z-M-7026

Methotrexate RS

CAS: 59-05-2

Colore e forma: From Yellow To Brownish Orange Solid Powder

Ref: 2K-1167000021

Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Single Solution

Peso molecolare: 454.44

Ref: TR-KIT0310

Methotrexate

CAS: 59-05-2

Stability Hygroscopic
Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Yellow To Dark Yellow

Peso molecolare: 454.44

Ref: TR-M260675

Methotrexate Heptaglutamate Trifluoroacetate

Prodotto controllato

CAS: 59-05-2

Formula: C₅₀H₆₄N₁₄O₂₃xC₂HF₃O₂

Colore e forma: Neat

Peso molecolare: 1229.12

Ref: TR-M260690

Methotrexate-d3 Heptaglutamate Trifluoroacetate

Prodotto controllato

CAS: 432545-63-6, 59-05-2

Formula: C₅₀H₆₁D₃N₁₄O₂₃xC₂HF₃O₂

Colore e forma: Neat

Peso molecolare: 1232.142

Ref: TR-M260692

Methotrexate

CAS: 59-05-2

Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.

Formula: C₂₀H₂₂N₈O₅

Colore e forma: Yellow Powder

Peso molecolare: 454.44 g/mol

Ref: 3D-FA25165

Methotrexate

CAS: 59-05-2

Purezza: 97%

Peso molecolare: 454.45

Ref: 10-F036492