CAS 591-28-6

4-Tiouracile

Descrizione:

4-Tiouracile è un derivato contenente zolfo dell'uracile, classificato come una base pirimidinica. La sua formula chimica è C4H4N2O2S e presenta un gruppo tiol (-SH) nella posizione 4 dell'anello dell'uracile, che lo distingue dall'uracile stesso. Questo composto è tipicamente un solido cristallino bianco a bianco sporco ed è solubile in acqua e alcol. 4-Tiouracile è noto per il suo ruolo come agente antitiroideo, poiché inibisce la sintesi degli ormoni tiroidei bloccando l'incorporazione di iodio nei residui di tirosina nella tireoglobulina. Inoltre, ha applicazioni in biochimica e biologia molecolare, in particolare in studi che coinvolgono RNA e metabolismo degli acidi nucleici. Il meccanismo d'azione del composto e la sua capacità di interferire con la sintesi degli acidi nucleici lo rendono uno strumento prezioso in contesti di ricerca e terapeutici. Tuttavia, come molte sostanze chimiche, deve essere maneggiato con cura a causa della potenziale tossicità e degli effetti collaterali associati al suo uso.

Formula: C₄H₄N₂OS

InChI: InChI=1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8)

InChI key: InChIKey=OVONXEQGWXGFJD-UHFFFAOYSA-N

SMILES: S=C1NC(=O)NC=C1

Sinonimi:

• Uracil, 4-thio-
• 4-Thiopyrimidin-2-one
• 2(1H)-Pyrimidinone, 3,4-dihydro-4-thioxo-
• 3,4-Dihydro-4-thioxo-2(1H)-pyrimidinone
• 4-Thiouracil

4-Thiouracil

CAS: 591-28-6

Formula: C₄H₄N₂OS

Purezza: >97.0%(T)(HPLC)

Colore e forma: Light yellow to Yellow to Green powder to crystal

Peso molecolare: 128.15

Ref: 3B-T2757

4-Thiouracil, 97%

CAS: 591-28-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₄H₄N₂OS

Purezza: 97%

Peso molecolare: 128.15

Ref: 02-H61919

4-Thiouracil

CAS: 591-28-6

Formula: C₄H₄N₂OS

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 128.1524

Ref: IN-DA00345K

4-Thiouracil

CAS: 591-28-6

Formula: C₄H₄N₂OS

Purezza: ≥ 97.0%

Colore e forma: Faint yellow to yellow powder

Peso molecolare: 128.16

Ref: 7W-GN5189

4-Thioxo-3,4-dihydropyrimidin-2(1H)-one

CAS: 591-28-6

4-Thioxo-3,4-dihydropyrimidin-2(1H)-one

Purezza: 97%

Peso molecolare: 128.15g/mol

Ref: 54-OR90861

4-Thiouracil

CAS: 591-28-6

Applications 4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.
References Miller, M., et al.: Nat. Methods, 6, 439 (2009); Seth, P., et al.: J. Med. Chem., 53, 8309 (2010); Cui, H., et al.: Eur. J. Med. Chem., 45, 5140 (2010);

Formula: C₄H₄N₂OS

Colore e forma: Neat

Peso molecolare: 128.152

Ref: TR-T375405

4-Thiouracil

CAS: 591-28-6

Formula: C₄H₄N₂OS

Purezza: 97%

Colore e forma: Slightly pale yellow – Yellow green powder

Peso molecolare: 128.15

Ref: 10-F013726

4-Thiouracil

CAS: 591-28-6

4-Thiouracil is a uridine analog and has been shown to inhibit transcriptional regulation by hydrogen bonding with the dna template. 4-Thiouracil is a prodrug that is converted to its active form, thiouracil, which inhibits DNA synthesis and cell proliferation by inhibiting the enzyme topoisomerase II. This results in the formation of abnormal DNA molecules that are not replicated properly. Thiouracil also has photochemical properties due to its ability to absorb light at wavelengths below 400 nm. The photochemical properties of 4-thiouracil have been studied extensively as models for human tissue culture and the study of cancer cells.

Formula: C₄H₄N₂OS

Purezza: Min. 97 Area-%

Colore e forma: Slightly Yellow Powder

Peso molecolare: 128.15 g/mol

Ref: 3D-FT02605

4-Thiouracil

CAS: 591-28-6

4-Thiouracil is a photoactivatable probe designated for site-specific applications in detecting RNA structures and nucleic acid-nucleic acid contacts. Upon illumination with ultraviolet light exceeding 300 nm and in the presence of oxygen, it serves as an energy donor, facilitating the generation of singlet oxygen through triplet-triplet energy transfer. This process enables the highly reactive oxygen species to interact with 4-thiouracil, leading to the formation of uracil and uracil-6-sulfonate; the latter exhibits fluorescence around a wavelength of approximately 390 nm. Additionally, 4-Thiouracil functions as a substrate for T. gondii uracil phosphoribosyltransferase, allowing the synthesis of 4-thiouridine monophosphate for subsequent integration into RNA.

Formula: C₄H₄N₂OS

Colore e forma: Solid

Peso molecolare: 128.15

Ref: TM-T84403